{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:03:15Z","timestamp":1781208195759,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009400","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM134542"],"award-info":[{"award-number":["R01GM134542"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["P01HL120839"],"award-info":[{"award-number":["P01HL120839"]}]},{"DOI":"10.13039\/100000084","name":"Directorate for Engineering","doi-asserted-by":"publisher","award":["DMR-1420570"],"award-info":[{"award-number":["DMR-1420570"]}],"id":[{"id":"10.13039\/100000084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM136259"],"award-info":[{"award-number":["R35GM136259"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>In eukaryotes, the cell volume is observed to be strongly correlated with the nuclear volume. The slope of this correlation depends on the cell type, growth condition, and the physical environment of the cell. We develop a computational model of cell growth and proteome increase, incorporating the kinetics of amino acid import, protein\/ribosome synthesis and degradation, and active transport of proteins between the cytoplasm and the nucleoplasm. We also include a simple model of ribosome biogenesis and assembly. Results show that the cell volume is tightly correlated with the nuclear volume, and the cytoplasm-nucleoplasm transport rates strongly influence the cell growth rate as well as the cell\/nucleus volume ratio (C\/N ratio). Ribosome assembly and the ratio of ribosomal proteins to mature ribosomes also influence the cell volume and the cell growth rate. We find that in order to regulate the cell growth rate and the cell\/nucleus volume ratio, the cell must optimally control groups of kinetic and transport parameters together, which could explain the quantitative roles of canonical growth pathways. Finally, although not explicitly demonstrated in this work, we point out that it is possible to construct a detailed proteome distribution using our model and RNAseq data, provided that a quantitative cell division mechanism is known.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1009400","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T13:44:51Z","timestamp":1645191891000},"page":"e1009400","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":74,"title":["The correlation between cell and nucleus size is explained by an eukaryotic cell growth model"],"prefix":"10.1371","volume":"18","author":[{"given":"Yufei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3334-227X","authenticated-orcid":true,"given":"Adrian F.","family":"Pegoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6678-5208","authenticated-orcid":true,"given":"David A.","family":"Weitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-3286","authenticated-orcid":true,"given":"Paul","family":"Janmey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9077-7088","authenticated-orcid":true,"given":"Sean X.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"issue":"4","key":"pcbi.1009400.ref001","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.200708054","article-title":"Nuclear size control in fission yeast","volume":"179","author":"FR Neumann","year":"2007","journal-title":"J Cell Biol"},{"issue":"4","key":"pcbi.1009400.ref002","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1083\/jcb.200710156","article-title":"The size-wise nucleus: nuclear volume control in eukaryotes","volume":"179","author":"MD Huber","year":"2007","journal-title":"J Cell Biol"},{"issue":"18","key":"pcbi.1009400.ref003","first-page":"3375","article-title":"Volume regulation and shape bifurcation in the cell nucleus","volume":"128","author":"DH Kim","year":"2015","journal-title":"J Cell Sci"},{"key":"pcbi.1009400.ref004","volume-title":"Molecular Biology of the Cell","author":"B Alberts","year":"2002","edition":"4"},{"issue":"6","key":"pcbi.1009400.ref005","doi-asserted-by":"crossref","first-page":"062406","DOI":"10.1103\/PhysRevE.101.062406","article-title":"Exponential trajectories, cell size fluctuations, and the adder property in bacteria follow from simple chemical dynamics and division control","volume":"101","author":"PP Pandey","year":"2020","journal-title":"Phys Rev E"},{"issue":"33","key":"pcbi.1009400.ref006","doi-asserted-by":"crossref","first-page":"e2107829118","DOI":"10.1073\/pnas.2107829118","article-title":"A unifying autocatalytic network-based framework for bacterial growth laws","volume":"118","author":"A Roy","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1009400.ref007","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-biochem-013118-110817","article-title":"Eukaryotic ribosome assembly","volume":"88","author":"J Ba\u00dfler","year":"2019","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"pcbi.1009400.ref008","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41580-018-0078-y","article-title":"Ribosome assembly coming into focus","volume":"20","author":"S Klinge","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"14","key":"pcbi.1009400.ref009","doi-asserted-by":"crossref","first-page":"R502","DOI":"10.1016\/S0960-9822(02)00970-3","article-title":"The Ran GTPase: theme and variations","volume":"12","author":"M Dasso","year":"2002","journal-title":"Curr Biol"},{"key":"pcbi.1009400.ref010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.plrev.2005.03.003","article-title":"Models of stochastic gene expression","volume":"2","author":"J Paulsson","year":"2005","journal-title":"Phys Life Rev"},{"issue":"9","key":"pcbi.1009400.ref011","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1073\/pnas.1910888117","article-title":"Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells","volume":"117","author":"Z Cao","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"pcbi.1009400.ref012","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/bip.22892","article-title":"Ribosome biogenesis in replicating cells: Integration of experiments and theory","volume":"105","author":"TM Earnest","year":"2016","journal-title":"Biopolymers"},{"issue":"4","key":"pcbi.1009400.ref013","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1049\/iet-syb.2017.0070","article-title":"Hybrid CME-ODE method for efficient simulation of the galactose switch in yeast","volume":"12","author":"DM Bianchi","year":"2018","journal-title":"IET Sys Biol"},{"issue":"3","key":"pcbi.1009400.ref014","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1083\/jcb.59.3.766","article-title":"Rapid, simultaneous measurement of DNA, protein, and cell volume in single cells from large mammalian cell populations","volume":"59","author":"HA Crissman","year":"1973","journal-title":"J Cell Biol"},{"issue":"2","key":"pcbi.1009400.ref015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/bulm.2000.0225","article-title":"A mathematical model for prokaryotic protein synthesis","volume":"63","author":"DA Drew","year":"2001","journal-title":"Bull Math Biol"},{"key":"pcbi.1009400.ref016","volume-title":"Fundamentals of chemical reaction engineering","author":"ME Davis","year":"2003"},{"issue":"4","key":"pcbi.1009400.ref017","doi-asserted-by":"crossref","first-page":"e00024","DOI":"10.1128\/MMBR.00024-19","article-title":"Regulation of amino acid transport in Saccharomyces cerevisiae","volume":"83","author":"F Bianchi","year":"2019","journal-title":"Microbiol Mol Biol Rev"},{"issue":"8","key":"pcbi.1009400.ref018","doi-asserted-by":"crossref","first-page":"747","DOI":"10.15252\/msb.20145379","article-title":"Emergence of robust growth laws from optimal regulation of ribosome synthesis","volume":"10","author":"M Scott","year":"2014","journal-title":"Mol Syst Biol"},{"issue":"6968","key":"pcbi.1009400.ref019","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nature02263","article-title":"Protein degradation and protection against misfolded or damaged proteins","volume":"426","author":"AL Goldberg","year":"2003","journal-title":"Nature"},{"issue":"4","key":"pcbi.1009400.ref020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0962-8924(94)90069-8","article-title":"Autophagy and related mechanisms of lysosome-mediated protein degradation","volume":"4","author":"WA Dunn","year":"1994","journal-title":"Trends Cell Biol"},{"key":"pcbi.1009400.ref021","doi-asserted-by":"crossref","DOI":"10.1201\/9780429258770","volume-title":"Cell biology by the numbers","author":"R Milo","year":"2015"},{"key":"pcbi.1009400.ref022","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fpls.2015.00425","article-title":"Quantitative description of ion transport via plasma membrane of yeast and small cells","volume":"6","author":"V Volkov","year":"2015","journal-title":"Front Plant Sci"},{"issue":"2","key":"pcbi.1009400.ref023","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2016.09.007","article-title":"Functional metabolomics describes the yeast biosynthetic regulome","volume":"167","author":"M M\u00fclleder","year":"2016","journal-title":"Cell"},{"key":"pcbi.1009400.ref024","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bpj.2015.08.025","article-title":"Active biochemical regulation of cell volume and a simple model of cell tension response","volume":"109","author":"J Tao","year":"2015","journal-title":"Biophys J"},{"key":"pcbi.1009400.ref025","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.bpj.2018.03.033","article-title":"Electromechanics and volume dynamics in nonexcitable tissue cells","volume":"114","author":"F Yellin","year":"2018","journal-title":"Biophys J"},{"key":"pcbi.1009400.ref026","doi-asserted-by":"crossref","first-page":"683686","DOI":"10.3389\/fcell.2021.683686","article-title":"Hydrogen, bicarbonate, and their associated exchangers in cell volume regulation","volume":"9","author":"Y Li","year":"2021","journal-title":"Frontiers Cell Dev Biol"},{"issue":"1","key":"pcbi.1009400.ref027","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/physrev.1990.70.1.43","article-title":"Role of amino acid transport and countertransport in nutrition and metabolism","volume":"70","author":"HN Christensen","year":"1990","journal-title":"Physiol Rev"},{"issue":"20","key":"pcbi.1009400.ref028","doi-asserted-by":"crossref","first-page":"jcs240341","DOI":"10.1242\/jcs.240341","article-title":"The importance of water and hydraulic pressure in cell dynamics","volume":"133","author":"Y Li","year":"2020","journal-title":"J Cell Sci"},{"issue":"1","key":"pcbi.1009400.ref029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1083\/jcb.201409047","article-title":"Accessorizing and anchoring the LINC complex for multifunctionality","volume":"208","author":"W Chang","year":"2015","journal-title":"J Cell Biol"},{"issue":"12","key":"pcbi.1009400.ref030","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1083\/jcb.201902046","article-title":"Vimentin protects cells against nuclear rupture and DNA damage during migration","volume":"218","author":"AE Patteson","year":"2019","journal-title":"J Cell Biol"},{"issue":"7","key":"pcbi.1009400.ref031","doi-asserted-by":"crossref","first-page":"a019091","DOI":"10.1101\/cshperspect.a019091","article-title":"Nuclear DNA content varies with cell size across human cell types","volume":"7","author":"JF Gillooly","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"5","key":"pcbi.1009400.ref032","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s12192-013-0413-3","article-title":"Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis","volume":"18","author":"A Finka","year":"2013","journal-title":"Cell Stress and Chaperones"},{"issue":"11","key":"pcbi.1009400.ref033","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0968-0004(99)01460-7","article-title":"The economics of ribosome biosynthesis in yeast","volume":"24","author":"JR Warner","year":"1999","journal-title":"Trends Biochem Sci"},{"issue":"5580","key":"pcbi.1009400.ref034","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.1070850","article-title":"Systematic identification of pathways that couple cell growth and division in yeast","volume":"297","author":"P Jorgensen","year":"2002","journal-title":"Science"},{"issue":"4","key":"pcbi.1009400.ref035","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.200708054","article-title":"Nuclear size control in fission yeast","volume":"179","author":"FR Neumann","year":"2007","journal-title":"J Cell Biol"},{"issue":"3","key":"pcbi.1009400.ref036","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1073\/pnas.0901851107","article-title":"Measurement of mass, density, and volume during the cell cycle of yeast","volume":"107","author":"AK Bryan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pcbi.1009400.ref037","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00455924","article-title":"Characterization of amino acid pools in the vacuolar compartment of Saccharomyces cerevisiae","volume":"101","author":"A Wiemken","year":"1974","journal-title":"Arch Microbiol"},{"key":"pcbi.1009400.ref038","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0021-9258(19)77326-8","article-title":"The free amino acid pool of cultured human cells","volume":"231","author":"KA Piez","year":"1958","journal-title":"J Biol Chem"},{"issue":"6","key":"pcbi.1009400.ref039","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1152\/jappl.1974.36.6.693","article-title":"Intracellular free amino acid concentration in human muscle tissue","volume":"36","author":"J Bergstr\u00f6m","year":"1974","journal-title":"J Appl Physiol"},{"issue":"12","key":"pcbi.1009400.ref040","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/bies.201300066","article-title":"What is the total number of protein molecules per cell volume? A call to rethink some published values","volume":"35","author":"R Milo","year":"2013","journal-title":"Bioessays"},{"issue":"1","key":"pcbi.1009400.ref041","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molcel.2017.05.021","article-title":"Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide","volume":"67","author":"Z Shi","year":"2017","journal-title":"Mol Cell"},{"issue":"13","key":"pcbi.1009400.ref042","doi-asserted-by":"crossref","first-page":"8917","DOI":"10.1074\/jbc.M509344200","article-title":"Dynamics of the Ras\/ERK MAPK cascade as monitored by fluorescent probes","volume":"281","author":"A Fujioka","year":"2006","journal-title":"J Biol Chem"},{"issue":"2","key":"pcbi.1009400.ref043","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/nbm.1173","article-title":"Intracellular water\u2014specific MR of microbead\u2014adherent cells: the HeLa cell intracellular water exchange lifetime","volume":"21","author":"L Zhao","year":"2008","journal-title":"NMR Biomed"},{"issue":"1","key":"pcbi.1009400.ref044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-05393-0","article-title":"Size control in mammalian cells involves modulation of both growth rate and cell cycle duration","volume":"9","author":"C Cadart","year":"2018","journal-title":"Nat Commun"},{"issue":"2","key":"pcbi.1009400.ref045","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cels.2017.12.004","article-title":"Unification of protein abundance datasets yields a quantitative Saccharomyces cerevisiae proteome","volume":"6","author":"B Ho","year":"2018","journal-title":"Cell Syst"},{"issue":"1","key":"pcbi.1009400.ref046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep15617","article-title":"Cellular economy in fission yeast cells continuously cultured with limited nitrogen resources","volume":"5","author":"Y Chikashige","year":"2015","journal-title":"Sci Rep"},{"issue":"15","key":"pcbi.1009400.ref047","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1021\/acs.jpcb.7b00672","article-title":"Challenges of integrating stochastic dynamics and cryo-electron tomograms in whole-cell simulations","volume":"121","author":"TM Earnest","year":"2017","journal-title":"J Phys Chem B"},{"issue":"10","key":"pcbi.1009400.ref048","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1093\/nar\/gki615","article-title":"Protein length in eukaryotic and prokaryotic proteomes","volume":"33","author":"L Brocchieri","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"pcbi.1009400.ref049","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"X Zhou","year":"2015","journal-title":"J Mol Cell Biol"},{"issue":"5","key":"pcbi.1009400.ref050","doi-asserted-by":"crossref","first-page":"F23","DOI":"10.1083\/jcb.151.5.F23","article-title":"The road to ribosomes: filling potholes in the export pathway","volume":"151","author":"JD Aitchison","year":"2000","journal-title":"J Cell Biol"},{"issue":"35","key":"pcbi.1009400.ref051","doi-asserted-by":"crossref","first-page":"13004","DOI":"10.1073\/pnas.0605420103","article-title":"Quantification of protein half-lives in the budding yeast proteome","volume":"103","author":"A Belle","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pcbi.1009400.ref052","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1083\/jcb.75.2.422","article-title":"Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division","volume":"75","author":"LH Hartwell","year":"1977","journal-title":"J Cell Biol"},{"issue":"2","key":"pcbi.1009400.ref053","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1574-6976.2011.00287.x","article-title":"The essence of yeast quiescence","volume":"36","author":"C De Virgilio","year":"2012","journal-title":"FEMS Microbiol Rev"},{"issue":"48","key":"pcbi.1009400.ref054","doi-asserted-by":"crossref","first-page":"E10329","DOI":"10.1073\/pnas.1710238114","article-title":"Proteome-wide modulation of degradation dynamics in response to growth arrest","volume":"114","author":"T Zhang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pcbi.1009400.ref055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13203-4","article-title":"Enhanced lysosomal degradation maintains the quiescent state of neural stem cells","volume":"10","author":"T Kobayashi","year":"2019","journal-title":"Nat Commun"},{"issue":"9","key":"pcbi.1009400.ref056","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.3390\/ijms20092158","article-title":"Quiescence entry, maintenance, and exit in adult stem cells","volume":"20","author":"K Mohammad","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"7759","key":"pcbi.1009400.ref057","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41586-019-1187-2","article-title":"Hypo-osmotic-like stress underlies general cellular defects of aneuploidy","volume":"570","author":"HJ Tsai","year":"2019","journal-title":"Nature"},{"issue":"11","key":"pcbi.1009400.ref058","first-page":"2528","article-title":"Tight coupling between nucleus and cell migration through the perinuclear actin cap","volume":"127","author":"DH Kim","year":"2014","journal-title":"J Cell Sci"},{"issue":"5","key":"pcbi.1009400.ref059","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2017.04.022","article-title":"Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression","volume":"169","author":"B Van Steensel","year":"2017","journal-title":"Cell"},{"issue":"85","key":"pcbi.1009400.ref060","doi-asserted-by":"crossref","first-page":"20130325","DOI":"10.1098\/rsif.2013.0325","article-title":"Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells","volume":"10","author":"EB Stukalin","year":"2013","journal-title":"J R Soc Interface"},{"key":"pcbi.1009400.ref061","doi-asserted-by":"crossref","first-page":"385601","DOI":"10.1088\/1751-8121\/abf532","article-title":"Kinetic theory for structured populations: application to stochastic sizer-timer models of cell proliferation","volume":"54","author":"M Xia","year":"2021","journal-title":"J Phys A: Math Theor"},{"issue":"5937","key":"pcbi.1009400.ref062","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.1174294","article-title":"Cell growth and size homeostasis in proliferating animal cells","volume":"325","author":"A Tzur","year":"2009","journal-title":"Science"},{"issue":"14","key":"pcbi.1009400.ref063","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1093\/nar\/gku555","article-title":"Single-cell RNA-seq: advances and future challenges","volume":"42","author":"AE Saliba","year":"2014","journal-title":"Nucl Acids Res"},{"issue":"6","key":"pcbi.1009400.ref064","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"PI3K\/AKT signaling pathway and cancer: an updated review","volume":"46","author":"M Martini","year":"2014","journal-title":"Ann Med"},{"issue":"3","key":"pcbi.1009400.ref065","first-page":"363","article-title":"Transforming growth factor-beta: a general review","volume":"7","author":"DA Lawrence","year":"1996","journal-title":"Eur Cytokine Netw"},{"issue":"6","key":"pcbi.1009400.ref066","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.08.053","article-title":"The regulation of cell size","volume":"154","author":"AC Lloyd","year":"2013","journal-title":"Cell"},{"issue":"1","key":"pcbi.1009400.ref067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo pathway regulation","volume":"30","author":"Z Meng","year":"2016","journal-title":"Genes Dev"},{"issue":"44","key":"pcbi.1009400.ref068","doi-asserted-by":"crossref","first-page":"27388","DOI":"10.1073\/pnas.2002152117","article-title":"Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth","volume":"117","author":"X Liu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7522","key":"pcbi.1009400.ref069","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13582","article-title":"Stochasticity of metabolism and growth at the single-cell level","volume":"514","author":"DJ Kiviet","year":"2014","journal-title":"Nature"},{"key":"pcbi.1009400.ref070","doi-asserted-by":"crossref","first-page":"e05856","DOI":"10.7554\/eLife.05856","article-title":"Expression noise facilitates the evolution of gene regulation","volume":"4","author":"L Wolf","year":"2015","journal-title":"eLife"},{"issue":"10","key":"pcbi.1009400.ref071","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1039\/C6IB00119J","article-title":"To grow is not enough: impact of noise and cell environmental response to fitness","volume":"8","author":"ND Rochman","year":"2016","journal-title":"Integ Biol"},{"key":"pcbi.1009400.ref072","unstructured":"PS-ON Cell Line Characterization."},{"key":"pcbi.1009400.ref073","doi-asserted-by":"crossref","first-page":"E8618","DOI":"10.1073\/pnas.1705179114","article-title":"Cell volume change through water efflux impacts cell stiffness and stem cell fate","volume":"114","author":"M Guo","year":"2017","journal-title":"Proc Natl Acad Sci"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1009400","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1009400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T14:35:51Z","timestamp":1646318151000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1009400"}},"subtitle":[],"editor":[{"given":"Oleg A","family":"Igoshin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1009400","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.01.458491","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,18]]}}}