{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:40:53Z","timestamp":1767181253465,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009569","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"foundation for the national institutes of health","doi-asserted-by":"publisher","award":["R01NS104911"],"award-info":[{"award-number":["R01NS104911"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"foundation for the national institutes of health","doi-asserted-by":"publisher","award":["R01NS104911"],"award-info":[{"award-number":["R01NS104911"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"foundation for the national institutes of health","doi-asserted-by":"publisher","award":["R01NS104911"],"award-info":[{"award-number":["R01NS104911"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Emergent response properties of sensory neurons depend on circuit connectivity and somatodendritic processing. Neurons of the barn owl\u2019s external nucleus of the inferior colliculus (ICx) display emergence of spatial selectivity. These neurons use interaural time difference (ITD) as a cue for the horizontal direction of sound sources. ITD is detected by upstream brainstem neurons with narrow frequency tuning, resulting in spatially ambiguous responses. This spatial ambiguity is resolved by ICx neurons integrating inputs over frequency, a relevant processing in sound localization across species. Previous models have predicted that ICx neurons function as point neurons that linearly integrate inputs across frequency. However, the complex dendritic trees and spines of ICx neurons raises the question of whether this prediction is accurate. Data from\n                    <jats:italic>in vivo<\/jats:italic>\n                    intracellular recordings of ICx neurons were used to address this question. Results revealed diverse frequency integration properties, where some ICx neurons showed responses consistent with the point neuron hypothesis and others with nonlinear dendritic integration. Modeling showed that varied connectivity patterns and forms of dendritic processing may underlie observed ICx neurons\u2019 frequency integration processing. These results corroborate the ability of neurons with complex dendritic trees to implement diverse linear and nonlinear integration of synaptic inputs, of relevance for adaptive coding and learning, and supporting a fundamental mechanism in sound localization.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009569","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T13:37:56Z","timestamp":1636637876000},"page":"e1009569","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diverse processing underlying frequency integration in midbrain neurons of barn owls"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-7123","authenticated-orcid":true,"given":"Julia C.","family":"Gorman","sequence":"first","affiliation":[]},{"given":"Oliver L.","family":"Tufte","sequence":"additional","affiliation":[]},{"given":"Anna V. 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Achard","year":"2006","journal-title":"PLoS Comput Biol"},{"key":"pcbi.1009569.ref003","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2735","article-title":"Multiple models to capture the variability in biological neurons and networks","volume":"14","author":"E Marder","year":"2011","journal-title":"Nat Neurosci"},{"key":"pcbi.1009569.ref004","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1152\/jn.00136.2018","article-title":"Degeneracy in the robust expression of spectral selectivity, subthreshold oscillations, and intrinsic excitability of entorhinal stellate cells","volume":"120","author":"D Mittal","year":"2018","journal-title":"J Neurophysiol"},{"key":"pcbi.1009569.ref005","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00359-005-0026-0","article-title":"Degenerate coding in neural systems","volume":"191","author":"A Leonardo","year":"2005","journal-title":"J Comp Physiol 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Knudsen","year":"1979","journal-title":"J Comp Physiol"},{"key":"pcbi.1009569.ref010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1523\/JNEUROSCI.01-01-00040.1981","article-title":"Neuronal and behavioral sensitivity to binaural time differences in the owl","volume":"1","author":"A Moiseff","year":"1981","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref011","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s003590100193","article-title":"Sound-localization experiments with barn owls in virtual space: influence of broadband interaural level difference on head-turning behavior","volume":"187","author":"I Poganiatz","year":"2001","journal-title":"J Comp Physiol A"},{"key":"pcbi.1009569.ref012","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1523\/JNEUROSCI.10-10-03227.1990","article-title":"A circuit for detection of interaural time differences in the brain stem of the barn owl","volume":"10","author":"CE Carr","year":"1990","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref013","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1523\/JNEUROSCI.07-10-03105.1987","article-title":"Representation of interaural time difference in the central nucleus of the barn owl\u2019s inferior colliculus","volume":"7","author":"H Wagner","year":"1987","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref014","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1523\/JNEUROSCI.06-12-03413.1986","article-title":"Selectivity for interaural time difference in the owl\u2019s midbrain","volume":"6","author":"T Takahashi","year":"1986","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref015","doi-asserted-by":"crossref","first-page":"10932","DOI":"10.1073\/pnas.95.18.10932","article-title":"How the owl resolves auditory coding ambiguity","volume":"95","author":"JA Mazer","year":"1998","journal-title":"Proc Natl Acad Sci"},{"key":"pcbi.1009569.ref016","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.95.11.6465","article-title":"How do owls localize interaurally phase-ambiguous signals?","volume":"95","author":"K Saberi","year":"1998","journal-title":"Proc Natl Acad Sci"},{"key":"pcbi.1009569.ref017","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/10212","article-title":"Neural bases of an auditory illusion and its elimination in owls","volume":"2","author":"K Saberi","year":"1999","journal-title":"Nat Neurosci"},{"key":"pcbi.1009569.ref018","doi-asserted-by":"crossref","first-page":"11787","DOI":"10.1073\/pnas.97.22.11787","article-title":"Cellular mechanisms for resolving phase ambiguity in the owl\u2019s inferior colliculus","volume":"97","author":"JL Pe\u00f1a","year":"2000","journal-title":"Proc Natl Acad Sci"},{"key":"pcbi.1009569.ref019","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1152\/jn.1995.74.4.1689","article-title":"Responses of neurons in the auditory pathway of the barn owl to partially correlated binaural signals","volume":"74","author":"Y Albeck","year":"1995","journal-title":"J Neurophysiol"},{"key":"pcbi.1009569.ref020","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1523\/JNEUROSCI.16-13-04300.1996","article-title":"Binaural cross-correlation predicts the responses of neurons in the owl\u2019s auditory space map under conditions simulating summing localization","volume":"16","author":"CH Keller","year":"1996","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref021","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0896-6273(00)80595-4","article-title":"Effects of interaural decorrelation on neural and behavioral detection of spatial cues","volume":"21","author":"K Saberi","year":"1998","journal-title":"Neuron"},{"key":"pcbi.1009569.ref022","doi-asserted-by":"crossref","first-page":"8107","DOI":"10.1523\/JNEUROSCI.1969-08.2008","article-title":"Cross-correlation in the 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model","volume":"84","author":"RM Stern","year":"1988","journal-title":"J Acoust Soc Am"},{"key":"pcbi.1009569.ref030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11554","article-title":"Synaptic amplification by dendritic spines enhances input cooperativity","volume":"491","author":"MT Harnett","year":"2012","journal-title":"Nature"},{"key":"pcbi.1009569.ref031","doi-asserted-by":"crossref","first-page":"18799","DOI":"10.1073\/pnas.0609225103","article-title":"Dendritic spines linearize the summation of excitatory potentials","volume":"103","author":"R Araya","year":"2006","journal-title":"Proc Natl Acad Sci"},{"key":"pcbi.1009569.ref032","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/cne.902180205","article-title":"Subdivisions of the inferior colliculus in the barn owl (Tyto alba)","volume":"218","author":"EI Knudsen","year":"1983","journal-title":"J Comp Neurol"},{"key":"pcbi.1009569.ref033","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0896-6273(03)00149-1","article-title":"Pyramidal neuron as two-layer neural network","volume":"37","author":"P Poirazi","year":"2003","journal-title":"Neuron"},{"key":"pcbi.1009569.ref034","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0896-6273(01)00252-5","article-title":"Impact of active dendrites and structural plasticity on the memory capacity of neural tissue","volume":"29","author":"P Poirazi","year":"2001","journal-title":"Neuron"},{"key":"pcbi.1009569.ref035","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nn1253","article-title":"Computational subunits in thin dendrites of pyramidal cells","volume":"7","author":"A Polsky","year":"2004","journal-title":"Nat Neurosci"},{"key":"pcbi.1009569.ref036","first-page":"102","article-title":"An augmented two-layer model captures nonlinear analog spatial integration effects in pyramidal neuron dendrites","author":"MP Jadi","year":"2014","journal-title":"Proc IEEE Inst Electr Electron Eng"},{"key":"pcbi.1009569.ref037","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fnmol.2019.00300","article-title":"Synaptic clustering and memory formation","volume":"12","author":"G Kastellakis","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"pcbi.1009569.ref038","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.neuron.2018.12.005","article-title":"Functional synaptic architecture of callosal inputs in mouse primary visual cortex","volume":"101","author":"K-S Lee","year":"2019","journal-title":"Neuron"},{"key":"pcbi.1009569.ref039","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1038\/s41467-019-11537-7","article-title":"Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators","volume":"10","author":"A Tzilivaki","year":"2019","journal-title":"Nat Commun"},{"key":"pcbi.1009569.ref040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fncom.2020.00057","article-title":"Emergence of stable synaptic clusters on dendrites through synaptic rewiring","volume":"14","author":"T Limbacher","year":"2020","journal-title":"Front Comput Neurosci"},{"key":"pcbi.1009569.ref041","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nlm.2015.01.011","article-title":"Input clustering in the normal and learned circuits of adult barn owls","volume":"121","author":"TJ McBride","year":"2015","journal-title":"Neurobiol Learn Mem"},{"key":"pcbi.1009569.ref042","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.conb.2008.08.013","article-title":"Synaptic clustering by dendritic signalling mechanisms","volume":"18","author":"ME Larkum","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"pcbi.1009569.ref043","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1523\/JNEUROSCI.23-31-10040.2003","article-title":"Multiplicative gain changes are induced by excitation or inhibition alone","volume":"23","author":"BK Murphy","year":"2003","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref044","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10827-007-0070-6","article-title":"Mechanism of gain modulation at single neuron and network levels","volume":"25","author":"M Brozovi\u0107","year":"2008","journal-title":"J Comput Neurosci"},{"key":"pcbi.1009569.ref045","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1152\/jn.1997.78.5.2772","article-title":"Direction selectivity of synaptic potentials in simple cells of the cat visual cortex","volume":"78","author":"B Jagadeesh","year":"1997","journal-title":"J Neurophysiol"},{"key":"pcbi.1009569.ref046","volume-title":"Biophysics of Computation: Information Processing in Single Neurons","author":"C Koch","year":"2004"},{"key":"pcbi.1009569.ref047","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.neuron.2016.03.019","article-title":"Mnemonic functions for nonlinear dendritic integration in hippocampal pyramidal circuits","volume":"90","author":"P Kaifosh","year":"2016","journal-title":"Neuron"},{"key":"pcbi.1009569.ref048","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/71125","article-title":"A model for intradendritic computation of binocular disparity","volume":"3","author":"KA Archie","year":"2000","journal-title":"Nat Neurosci"},{"key":"pcbi.1009569.ref049","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature01190","article-title":"Multiplicative computation in a visual neuron sensitive to looming","volume":"420","author":"F Gabbiani","year":"2002","journal-title":"Nature"},{"key":"pcbi.1009569.ref050","doi-asserted-by":"crossref","first-page":"e1002867","DOI":"10.1371\/journal.pcbi.1002867","article-title":"Passive dendrites enable single neurons to compute linearly non-separable functions","volume":"9","author":"RD Caz\u00e9","year":"2013","journal-title":"PLOS Comput Biol"},{"key":"pcbi.1009569.ref051","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1523\/JNEUROSCI.13-11-04589.1993","article-title":"Experience-dependent plasticity in the inferior colliculus: a site for visual calibration of the neural representation of auditory space in the barn owl","volume":"13","author":"MS Brainard","year":"1993","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref052","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.271.5248.525","article-title":"Newly learned auditory responses mediated by NMDA receptors in the owl inferior colliculus","volume":"271","author":"DE Feldman","year":"1996","journal-title":"Science"},{"key":"pcbi.1009569.ref053","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.tins.2008.08.006","article-title":"Micro-rewiring as a substrate for learning","volume":"31","author":"WM DeBello","year":"2008","journal-title":"Trends Neurosci"},{"key":"pcbi.1009569.ref054","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1152\/jn.1984.52.4.709","article-title":"Auditory properties of space-tuned units in owl\u2019s optic tectum","volume":"52","author":"EI Knudsen","year":"1984","journal-title":"J Neurophysiol"},{"key":"pcbi.1009569.ref055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00359-003-0476-1","article-title":"Sensitivity to spectral interaural intensity difference cues in space-specific neurons of the barn owl","volume":"190","author":"BJ Arthur","year":"2004","journal-title":"J Comp Physiol A"},{"key":"pcbi.1009569.ref056","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1152\/jn.01072.2010","article-title":"Anesthetic state modulates excitability but not spectral tuning or neural discrimination in single auditory midbrain neurons","volume":"106","author":"JW Schumacher","year":"2011","journal-title":"J Neurophysiol"},{"key":"pcbi.1009569.ref057","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuron.2018.08.032","article-title":"Global and multiplexed dendritic computations under in vivo-like conditions","volume":"100","author":"BB Ujfalussy","year":"2018","journal-title":"Neuron"},{"key":"pcbi.1009569.ref058","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1523\/JNEUROSCI.17-17-06820.1997","article-title":"An anatomical basis for visual calibration of the auditory space map in the barn owl\u2019s midbrain","volume":"17","author":"DE Feldman","year":"1997","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref059","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1523\/JNEUROSCI.21-09-03161.2001","article-title":"Adaptive axonal remodeling in the midbrain auditory space map","volume":"21","author":"WM DeBello","year":"2001","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref060","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1523\/JNEUROSCI.22-13-05652.2002","article-title":"From postsynaptic potentials to spikes in the genesis of auditory spatial receptive fields","volume":"22","author":"JL Pena","year":"2002","journal-title":"J Neurosci"},{"key":"pcbi.1009569.ref061","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1523\/JNEUROSCI.11-03-00722.1991","article-title":"The role of GABAergic inhibition in processing of interaural time difference in the owl\u2019s auditory system","volume":"11","author":"I Fujita","year":"1991","journal-title":"J 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