{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:17:37Z","timestamp":1772173057349,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009605","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000}}],"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670852"],"award-info":[{"award-number":["31670852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    The collective behavior of the nuclear array in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    embryos during nuclear cycle (NC) 11 to NC14 is crucial in controlling cell size, establishing developmental patterns, and coordinating morphogenesis. After live imaging on\n                    <jats:italic>Drosophila<\/jats:italic>\n                    embryos with light sheet microscopy, we extract the nuclear trajectory, speed, and internuclear distance with an automatic nuclear tracing method. We find that the nuclear speed shows a period of standing waves along the anterior-posterior (AP) axis after each metaphase as the nuclei collectively migrate towards the embryo poles and partially move back. And the maximum nuclear speed dampens by 28-45% in the second half of the standing wave. Moreover, the nuclear density is 22\u201342% lower in the pole region than the middle of the embryo during the interphase of NC12-14. To find mechanical rules controlling the collective motion and packing patterns of the nuclear array, we use a deep neural network (DNN) to learn the underlying force field from data. We apply the learned spatiotemporal attractive force field in the simulations with a particle-based model. And the simulations recapitulate nearly all the observed characteristic collective behaviors of nuclear arrays in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    embryos.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009605","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T13:38:20Z","timestamp":1637329100000},"page":"e1009605","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Attractive internuclear force drives the collective behavior of nuclear arrays in Drosophila embryos"],"prefix":"10.1371","volume":"17","author":[{"given":"Xiaoxuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-7118","authenticated-orcid":true,"given":"Kakit","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-6127","authenticated-orcid":true,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"pcbi.1009605.ref001","doi-asserted-by":"crossref","first-page":"e27454","DOI":"10.7554\/eLife.27454","article-title":"Global morphogenetic flow is accurately predicted by the spatial distribution of myosin 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