{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:24:37Z","timestamp":1774880677187,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009691","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000}}],"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["200020_184615"],"award-info":[{"award-number":["200020_184615"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["200020_184615"],"award-info":[{"award-number":["200020_184615"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["785907"],"award-info":[{"award-number":["785907"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["785907"],"award-info":[{"award-number":["785907"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Assemblies of neurons, called concepts cells, encode acquired concepts in human Medial Temporal Lobe. Those concept cells that are shared between two assemblies have been hypothesized to encode associations between concepts. Here we test this hypothesis in a computational model of attractor neural networks. We find that for concepts encoded in sparse neural assemblies there is a minimal fraction\n                    <jats:italic>c<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    of neurons shared between assemblies below which associations cannot be reliably implemented; and a maximal fraction\n                    <jats:italic>c<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    of shared neurons above which single concepts can no longer be retrieved. In the presence of a periodically modulated background signal, such as hippocampal oscillations, recall takes the form of association chains reminiscent of those postulated by theories of free recall of words. Predictions of an iterative overlap-generating model match experimental data on the number of concepts to which a neuron responds.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009691","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T13:31:41Z","timestamp":1640871101000},"page":"e1009691","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["When shared concept cells support associations: Theory of overlapping memory engrams"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-7652","authenticated-orcid":true,"given":"Chiara","family":"Gastaldi","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-3723","authenticated-orcid":true,"given":"Tilo","family":"Schwalger","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-7229","authenticated-orcid":true,"given":"Emanuela","family":"De Falco","sequence":"additional","affiliation":[]},{"given":"Rodrigo Quian","family":"Quiroga","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4344-2189","authenticated-orcid":true,"given":"Wulfram","family":"Gerstner","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"issue":"7045","key":"pcbi.1009691.ref001","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nature03687","article-title":"Invariant visual representation by single neurons in the human brain","volume":"435","author":"R Quian Quiroga","year":"2005","journal-title":"Nature"},{"key":"pcbi.1009691.ref002","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.2741\/3048","article-title":"Selectivity and invariance for visual object perception","volume":"13","author":"Matias J Ison","year":"2008","journal-title":"Front Biosci"},{"issue":"6434","key":"pcbi.1009691.ref003","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1126\/science.aaw8829","article-title":"Neural representations across species","volume":"363","author":"Rodrigo Quian Quiroga","year":"2019","journal-title":"Science"},{"issue":"40","key":"pcbi.1009691.ref004","doi-asserted-by":"crossref","first-page":"10232","DOI":"10.1523\/JNEUROSCI.2101-06.2006","article-title":"Sparse representation in the human medial temporal lobe","volume":"26","author":"Stephen Waydo","year":"2006","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"pcbi.1009691.ref005","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuron.2015.06.016","article-title":"Rapid encoding of new memories by individual neurons in the human brain","volume":"87","author":"Matias J Ison","year":"2015","journal-title":"Neuron"},{"key":"pcbi.1009691.ref006","doi-asserted-by":"crossref","first-page":"13408","DOI":"10.1038\/ncomms13408","article-title":"Long-term coding of personal and universal associations underlying the memory web in the human brain","volume":"7","author":"Emanuela De Falco","year":"2016","journal-title":"Nature communications"},{"issue":"1","key":"pcbi.1009691.ref007","first-page":"1","article-title":"Encoding of long-term associations through neural unitization in the human medial temporal lobe","volume":"9","author":"Hernan G Rey","year":"2018","journal-title":"Nature communications"},{"issue":"6","key":"pcbi.1009691.ref008","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.cub.2020.01.035","article-title":"Single neuron coding of identity in the human hippocampal formation","volume":"30","author":"Hernan G. 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