{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:48:19Z","timestamp":1776664099700,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009717","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000}}],"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SPARC (Stimulating Peripheral Activity to Relieve Conditions) program OT2OD023859"],"award-info":[{"award-number":["SPARC (Stimulating Peripheral Activity to Relieve Conditions) program OT2OD023859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1158952"],"award-info":[{"award-number":["GNT1158952"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Transmission between neurons in the extensive enteric neural networks of the gut involves synaptic potentials with vastly different time courses and underlying conductances. Most enteric neurons exhibit fast excitatory post-synaptic potentials (EPSPs) lasting 20\u201350 ms, but many also exhibit slow EPSPs that last up to 100 s. When large enough, slow EPSPs excite action potentials at the start of the slow depolarization, but how they affect action potentials evoked by fast EPSPs is unknown. Furthermore, two other sources of synaptic depolarization probably occur in enteric circuits, activated via GABA\n                    <jats:sub>A<\/jats:sub>\n                    or GABA\n                    <jats:sub>C<\/jats:sub>\n                    receptors; how these interact with other synaptic depolarizations is also unclear. We built a compartmental model of enteric neurons incorporating realistic voltage-dependent ion channels, then simulated fast EPSPs, slow EPSPs and GABA\n                    <jats:sub>A<\/jats:sub>\n                    or GABA\n                    <jats:sub>C<\/jats:sub>\n                    ligand-gated Cl\n                    <jats:sup>-<\/jats:sup>\n                    channels to explore these interactions. Model predictions were tested by imaging Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transients in myenteric neurons ex vivo as an indicator of their activity during synaptic interactions. The model could mimic firing of myenteric neurons in mouse colon evoked by depolarizing current during intracellular recording and the fast and slow EPSPs in these neurons. Subthreshold fast EPSPs evoked spikes during the rising phase of a slow EPSP, but suprathreshold fast EPSPs could not evoke spikes later in a slow EPSP. This predicted inhibition was confirmed by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging in which stimuli that evoke slow EPSPs suppressed activity evoked by fast EPSPs in many myenteric neurons. The model also predicted that synchronous activation of GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors and fast EPSPs potentiated firing evoked by the latter, while synchronous activation of GABA\n                    <jats:sub>C<\/jats:sub>\n                    receptors with fast EPSPs, potentiated firing and then suppressed it. The results reveal that so-called slow EPSPs have a biphasic effect being likely to suppress fast EPSP evoked firing over very long periods, perhaps accounting for prolonged quiescent periods seen in enteric motor patterns.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009717","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T13:50:39Z","timestamp":1655128239000},"page":"e1009717","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Computational simulations and Ca2+ imaging reveal that slow synaptic depolarizations (slow EPSPs) inhibit fast EPSP evoked action potentials for most of their time course in enteric neurons"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-6445","authenticated-orcid":true,"given":"Parvin","family":"Zarei Eskikand","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5824-1814","authenticated-orcid":true,"given":"Katerina","family":"Koussoulas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-2045","authenticated-orcid":true,"given":"Rachel M.","family":"Gwynne","sequence":"additional","affiliation":[]},{"given":"Joel C.","family":"Bornstein","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"issue":"1\u20132","key":"pcbi.1009717.ref001","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.autneu.2006.01.007","article-title":"Novel gut afferents: Intrinsic afferent neurons and intestinofugal neurons","volume":"125","author":"JB Furness","year":"2006","journal-title":"Auton 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