{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:18:56Z","timestamp":1775909936819,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009761","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000}}],"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31571367"],"award-info":[{"award-number":["31571367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2019CFB685"],"award-info":[{"award-number":["2019CFB685"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>The origin of life involved complicated evolutionary processes. Computer modeling is a promising way to reveal relevant mechanisms. However, due to the limitation of our knowledge on prebiotic chemistry, it is usually difficult to justify parameter-setting for the modeling. Thus, typically, the studies were conducted in a reverse way: the parameter-space was explored to find those parameter values \u201csupporting\u201d a hypothetical scene (that is, leaving the parameter-justification a later job when sufficient knowledge is available). Exploring the parameter-space manually is an arduous job (especially when the modeling becomes complicated) and additionally, difficult to characterize as regular \u201cMethods\u201d in a paper. Here we show that a machine-learning-like approach may be adopted, automatically optimizing the parameters. With this efficient parameter-exploring approach, the evolutionary modeling on the origin of life would become much more powerful. In particular, based on this, it is expected that more near-reality (complex) models could be introduced, and thereby theoretical research would be more tightly associated with experimental investigation in this field\u2013hopefully leading to significant steps forward in respect to our understanding on the origin of life.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1009761","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T18:38:45Z","timestamp":1640803125000},"page":"e1009761","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The automatic parameter-exploration with a machine-learning-like approach: Powering the evolutionary modeling on the origin of life"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-9929","authenticated-orcid":true,"given":"Yuzhen","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunwu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-7695","authenticated-orcid":true,"given":"Wentao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"pcbi.1009761.ref001","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/073911012010524998","article-title":"Attempts to define life do not help to understand the origin of life","volume":"29","author":"JW Szostak","year":"2012","journal-title":"J Biomol Struct Dyn"},{"key":"pcbi.1009761.ref002","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11084-012-9298-x","article-title":"Open questions on the origin of life (OQOL)","volume":"42","author":"D Raine","year":"2012","journal-title":"Orig life Evol Biosph"},{"key":"pcbi.1009761.ref003","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/cbdv.201400188","article-title":"The origin of life: A problem of history, chemistry, and evolution.","volume":"11","author":"WT Ma","year":"2014","journal-title":"Chem Biodiver"},{"key":"pcbi.1009761.ref004","doi-asserted-by":"crossref","first-page":"20160346","DOI":"10.1098\/rsta.2016.0346","article-title":"Conceptualizing the origin of life in terms of evolution","volume":"375","author":"N Takeuchi","year":"2017","journal-title":"Phil Trans R Soc A"},{"key":"pcbi.1009761.ref005","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.117.3046.528","article-title":"A production of amino acids under possible primitive Earth condition","volume":"117","author":"SL Miller","year":"1953","journal-title":"Science"},{"key":"pcbi.1009761.ref006","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/anie.201204968","article-title":"The origins of life: Old problems, new chemistries","volume":"52","author":"S. 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