{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:51:11Z","timestamp":1776084671190,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009867","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000}}],"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH115831-01"],"award-info":[{"award-number":["R01 MH115831-01"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Human Frontiers Science Program","award":["RGY0076\/2018"],"award-info":[{"award-number":["RGY0076\/2018"]}]},{"DOI":"10.13039\/100001309","name":"Research Corporation for Science Advancement","doi-asserted-by":"publisher","award":["25999"],"award-info":[{"award-number":["25999"]}],"id":[{"id":"10.13039\/100001309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000166","name":"Division of Physics","doi-asserted-by":"publisher","award":["PHY-1806833"],"award-info":[{"award-number":["PHY-1806833"]}],"id":[{"id":"10.13039\/100000166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["GM098090"],"award-info":[{"award-number":["GM098090"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000166","name":"Division of Physics","doi-asserted-by":"publisher","award":["PHY-1734030"],"award-info":[{"award-number":["PHY-1734030"]}],"id":[{"id":"10.13039\/100000166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Aging affects almost all aspects of an organism\u2014its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal\u2019s behavior across the lifespan. Using data from fruit flies (\n                    <jats:italic>D. melanogaster<\/jats:italic>\n                    ) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly\u2019s overall energy budget, suggesting potential connections between metabolism, aging, and behavior.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009867","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T13:50:39Z","timestamp":1645710639000},"page":"e1009867","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9257","authenticated-orcid":true,"given":"Katherine E.","family":"Overman","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-4783","authenticated-orcid":true,"given":"Daniel M.","family":"Choi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-0666","authenticated-orcid":true,"given":"Kawai","family":"Leung","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-4723","authenticated-orcid":true,"given":"Joshua W.","family":"Shaevitz","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3588-7820","authenticated-orcid":true,"given":"Gordon J.","family":"Berman","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"pcbi.1009867.ref001","volume-title":"Biology of aging: observations and principles","author":"R Arking","year":"2006"},{"issue":"1","key":"pcbi.1009867.ref002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.arr.2004.08.002","article-title":"Insights into age-related locomotor declines from studies of insects","volume":"4","author":"AL Ridgel","year":"2005","journal-title":"Ageing Research Reviews"},{"issue":"5","key":"pcbi.1009867.ref003","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neubiorev.2009.10.005","article-title":"Motor control and aging: Links to age-related brain structural, functional, and biochemical effects","volume":"34","author":"RD Seidler","year":"2010","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"7288","key":"pcbi.1009867.ref004","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08983","article-title":"Neural mechanisms of ageing and cognitive decline","volume":"464","author":"NA Bishop","year":"2010","journal-title":"Nature"},{"issue":"6809","key":"pcbi.1009867.ref005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35041682","article-title":"Why do we age?","volume":"408","author":"TBL Kirkwood","year":"2000","journal-title":"Nature"},{"issue":"1","key":"pcbi.1009867.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2009.08.002","article-title":"Energy expenditure and aging","volume":"9","author":"TM Manini","year":"2010","journal-title":"Ageing Research Reviews"},{"key":"pcbi.1009867.ref007","first-page":"221","article-title":"The comparative method in studying innate behavior patterns","author":"KZ Lorenz","year":"1950","journal-title":"Society for Experimental Biology"},{"issue":"7-8","key":"pcbi.1009867.ref008","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1242\/dmm.001040","article-title":"The role of insulin\/IGF-like signaling in C. elegans longevity and aging","volume":"3","author":"R Kaletsky","year":"2010","journal-title":"Disease Models & Mechanisms"},{"key":"pcbi.1009867.ref009","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fendo.2015.00013","article-title":"Insulin, Aging, and the Brain: Mechanisms and Implications","volume":"6","author":"AA Akintola","year":"2015","journal-title":"Frontiers in Endocrinology"},{"key":"pcbi.1009867.ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1895\/wormbook.1.164.1","article-title":"Insulin\/insulin-like growth factor signaling in C. elegans","author":"CT Murphy","year":"2013","journal-title":"WormBook"},{"issue":"4","key":"pcbi.1009867.ref011","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0167-4943(83)90003-1","article-title":"Patterns of movement and ageing in Drosophila melanogaster","volume":"2","author":"EL Bourg","year":"1983","journal-title":"Archives of Gerontology and Geriatrics"},{"issue":"5","key":"pcbi.1009867.ref012","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0531-5565(87)90034-9","article-title":"The rate of living theory. 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