{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:18:21Z","timestamp":1772173101573,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009872","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000}}],"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["3730\/20"],"award-info":[{"award-number":["3730\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>COVID-19 vaccines have been approved for children of age five and older in many countries. However, there is an ongoing debate as to whether children should be vaccinated and at what priority. In this work, we use mathematical modeling and optimization to study how vaccine allocations to different age groups effect epidemic outcomes. In particular, we consider the effect of extending vaccination campaigns to include the vaccination of children. When vaccine availability is limited, we consider Pareto-optimal allocations with respect to competing measures of the number of infections and mortality and systematically study the trade-offs among them. In the scenarios considered, when some weight is given to the number of infections, we find that it is optimal to allocate vaccines to adolescents in the age group 10-19, even when they are assumed to be less susceptible than adults. We further find that age group 0-9 is included in the optimal allocation for sufficiently high values of the basic reproduction number.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1009872","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T14:15:21Z","timestamp":1645798521000},"page":"e1009872","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of childrens\u2019 vaccination for COVID-19\u2014Pareto-optimal allocations of vaccines"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-3243","authenticated-orcid":true,"given":"Nir","family":"Gavish","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-4789","authenticated-orcid":true,"given":"Guy","family":"Katriel","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"pcbi.1009872.ref001","article-title":"How antiviral pill molnupiravir shot ahead in the COVID drug hunt","author":"C Willyard","year":"2021","journal-title":"Nature (Lond)"},{"issue":"7813","key":"pcbi.1009872.ref002","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/d41586-020-01824-5","article-title":"Coronavirus breakthrough: dexamethasone is first drug shown to save lives","volume":"582","author":"H Ledford","year":"2020","journal-title":"Nature"},{"key":"pcbi.1009872.ref003","author":"S Lopez-Leon","year":"2021","journal-title":"More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis"},{"key":"pcbi.1009872.ref004","doi-asserted-by":"crossref","unstructured":"FDA Authorizes Pfizer-BioNTech COVID-19 Vaccine for Emergency Use in Children 5 through 11 Years of Age. 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