{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:24:05Z","timestamp":1767176645168,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010051","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000}}],"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MIUR-PRIN","award":["2017Z55KCW"],"award-info":[{"award-number":["2017Z55KCW"]}]},{"name":"IPGG Laboratoire d\u2019Excellence","award":["ANR-10-IDEX-0001-02 PSL"],"award-info":[{"award-number":["ANR-10-IDEX-0001-02 PSL"]}]},{"name":"IPGG Laboratoire d\u2019Excellence","award":["ANR-10-LABX-31"],"award-info":[{"award-number":["ANR-10-LABX-31"]}]},{"name":"IPGG Laboratoire d\u2019Excellence","award":["ANR-10-EQPX-34"],"award-info":[{"award-number":["ANR-10-EQPX-34"]}]},{"DOI":"10.13039\/501100003500","name":"UNIPD","doi-asserted-by":"crossref","award":["BIRD209912"],"award-info":[{"award-number":["BIRD209912"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FEDER\/Ministerio de Ciencia e Innovacion-Agencia Estatal de Investigacion","award":["PGC2018-093998-B-I00"],"award-info":[{"award-number":["PGC2018-093998-B-I00"]}]},{"name":"Junta de Andalucia and European Social Fund","award":["PAIDI-DOCTOR"],"award-info":[{"award-number":["PAIDI-DOCTOR"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Understanding of the pairing statistics in solutions populated by a large number of distinct solute species with mutual interactions is a challenging topic, relevant in modeling the complexity of real biological systems. Here we describe, both experimentally and theoretically, the formation of duplexes in a solution of random-sequence DNA (rsDNA) oligomers of length\n                    <jats:italic>L<\/jats:italic>\n                    = 8, 12, 20 nucleotides. rsDNA solutions are formed by 4\n                    <jats:sup>\n                      <jats:italic>L<\/jats:italic>\n                    <\/jats:sup>\n                    distinct molecular species, leading to a variety of pairing motifs that depend on sequence complementarity and range from strongly bound, fully paired defectless helices to weakly interacting mismatched duplexes. Experiments and theory coherently combine revealing a hybridization statistics characterized by a prevalence of partially defected duplexes, with a distribution of type and number of pairing errors that depends on temperature. We find that despite the enormous multitude of inter-strand interactions, defectless duplexes are formed, involving a fraction up to 15% of the rsDNA chains at the lowest temperatures. Experiments and theory are limited here to equilibrium conditions.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1010051","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T13:37:48Z","timestamp":1649684268000},"page":"e1010051","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pairing statistics and melting of random DNA oligomers: Finding your partner in superdiverse environments"],"prefix":"10.1371","volume":"18","author":[{"given":"Simone","family":"Di Leo","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-3002","authenticated-orcid":true,"given":"Stefano","family":"Marni","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-6854","authenticated-orcid":true,"given":"Carlos 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