{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:46:09Z","timestamp":1771958769090,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010105","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1743392"],"award-info":[{"award-number":["1743392"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2019745"],"award-info":[{"award-number":["2019745"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1522550"],"award-info":[{"award-number":["1522550"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["C0016"],"award-info":[{"award-number":["C0016"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1531814"],"award-info":[{"award-number":["1531814"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Actin networks are essential for living cells to move, reproduce, and sense their environments. The dynamic and rheological behavior of actin networks is modulated by actin-binding proteins such as \u03b1-actinin, Arp2\/3, and myosin. There is experimental evidence that actin-binding proteins modulate the cooperation of myosin motors by connecting the actin network. In this work, we present an analytical mean field model, using the Flory-Stockmayer theory of gelation, to understand how different actin-binding proteins change the connectivity of the actin filaments as the networks are formed. We follow the kinetics of the networks and estimate the concentrations of actin-binding proteins that are needed to reach connectivity percolation as well as to reach rigidity percolation. We find that Arp2\/3 increases the actomyosin connectivity in the network in a non-monotonic way. We also describe how changing the connectivity of actomyosin networks modulates the ability of motors to exert forces, leading to three possible phases of the networks with distinctive dynamical characteristics: a sol phase, a gel phase, and an active phase. Thus, changes in the concentration and activity of actin-binding proteins in cells lead to a phase transition of the actin network, allowing the cells to perform active contraction and change their rheological properties.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010105","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T17:41:56Z","timestamp":1652118116000},"page":"e1010105","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["A generalized Flory-Stockmayer kinetic theory of connectivity percolation and rigidity percolation of cytoskeletal networks"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-6128","authenticated-orcid":true,"given":"Carlos","family":"Bueno","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-9004","authenticated-orcid":true,"given":"James","family":"Liman","sequence":"additional","affiliation":[]},{"given":"Nicholas P.","family":"Schafer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9235-7661","authenticated-orcid":true,"given":"Margaret S.","family":"Cheung","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-9287","authenticated-orcid":true,"given":"Peter G.","family":"Wolynes","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"pcbi.1010105.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a018267","article-title":"The actin cytoskeleton and 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