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In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral population remains unclear. Using stochastic simulations, we find that genetic drift is suppressed when superinfection occurs, thus facilitating the fixation of beneficial mutations and the removal of deleterious ones. Interestingly, we also find that the competitive (dis)advantage associated with variations in life history parameters is not necessarily captured by the viral growth rate for either infection strategy. Putting these together, we then show that a mutant with superinfection exclusion will easily overtake a superinfecting population even if the latter has a much higher growth rate. Our findings suggest that while superinfection exclusion can negatively impact the long-term adaptation of a viral population, in the short-term it is ultimately a winning strategy.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010125","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T13:59:57Z","timestamp":1652191197000},"page":"e1010125","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["Superinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-2896","authenticated-orcid":true,"given":"Michael","family":"Hunter","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-7160","authenticated-orcid":true,"given":"Diana","family":"Fusco","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"pcbi.1010125.ref001","volume-title":"An Interscience reprint","author":"MH Adams","year":"1959"},{"key":"pcbi.1010125.ref002","doi-asserted-by":"crossref","first-page":"JULY2015","DOI":"10.7554\/eLife.08490","article-title":"Viral dark matter and virus\u2013host interactions resolved from publicly available microbial genomes","volume":"4","author":"S Roux","year":"2015","journal-title":"eLife"},{"issue":"1","key":"pcbi.1010125.ref003","article-title":"Viral coinfection is shaped by host ecology and virus-virus interactions across diverse microbial taxa and environments","volume":"3","author":"SL D\u00edaz-Mu\u00f1oz","year":"2017","journal-title":"Virus Evolution"},{"key":"pcbi.1010125.ref004","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/CBO9780511541483.011","volume-title":"Bacteriophage Ecology","author":"PE Turner","year":"2008"},{"issue":"5","key":"pcbi.1010125.ref005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrmicro2315","article-title":"Bacteriophage resistance mechanisms","volume":"8","author":"SJ Labrie","year":"2010","journal-title":"Nature Reviews Microbiology"},{"issue":"3","key":"pcbi.1010125.ref006","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/MMBR.00011-16","article-title":"Evolutionary Ecology of Prokaryotic Immune Mechanisms","volume":"80","author":"S van Houte","year":"2016","journal-title":"Microbiology and molecular biology reviews: MMBR"},{"issue":"15","key":"pcbi.1010125.ref007","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1128\/jb.176.15.4710-4717.1994","article-title":"Inactivation of FhuA at the cell surface of Escherichia coli K-12 by a phage T5 lipoprotein at the periplasmic face of the outer membrane","volume":"176","author":"V Braun","year":"1994","journal-title":"Journal of Bacteriology"},{"issue":"1","key":"pcbi.1010125.ref008","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1574-6968.1998.tb13264.x","article-title":"Inactivation in vitro of the Escherichia coli outer membrane protein FhuA by a phage T5-encoded lipoprotein","volume":"168","author":"I Pedruzzi","year":"1998","journal-title":"FEMS Microbiology Letters"},{"issue":"8","key":"pcbi.1010125.ref009","article-title":"Location and unusual membrane topology of the immunity protein of the Escherichia coli phage T4","volume":"67","author":"MJ Lu","year":"1993","journal-title":"Journal of Virology"},{"issue":"4","key":"pcbi.1010125.ref010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0966-842X(94)90601-7","article-title":"Superinfection exclusion by T-even-type coliphages","volume":"2","author":"MJ Lu","year":"1994","journal-title":"Trends in Microbiology"},{"key":"pcbi.1010125.ref011","doi-asserted-by":"crossref","unstructured":"Frank SA. 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