{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:35:29Z","timestamp":1772595329901,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010134","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000}}],"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio Ciencia Gob Espa\u00f1a","award":["PID2019-110185RB-C22"],"award-info":[{"award-number":["PID2019-110185RB-C22"]}]},{"name":"Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion, Consejeria de Economia Conocimiento y Empleo del Gobierno de Canarias","award":["PROID2020010022"],"award-info":[{"award-number":["PROID2020010022"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>There is a growing interest in biomedical engineering in developing procedures that provide accurate simulations of the neural response to electrical stimulus produced by implants. Moreover, recent research focuses on models that take into account individual patient characteristics.<\/jats:p>\n<jats:p>We present a phenomenological computational model that is customized with the patient\u2019s data provided by the electrically evoked compound action potential (ECAP) for simulating the neural response to electrical stimulus produced by the electrodes of cochlear implants (CIs). The model links the input currents of the electrodes to the simulated ECAP.<\/jats:p>\n<jats:p>Potentials and currents are calculated by solving the quasi-static approximation of the Maxwell equations with the finite element method (FEM). In ECAPs recording, an active electrode generates a current that elicits action potentials in the surrounding auditory nerve fibers (ANFs). The sum of these action potentials is registered by other nearby electrode. Our computational model emulates this phenomenon introducing a set of line current sources replacing the ANFs by a set of virtual neurons (VNs). To fit the ECAP amplitudes we assign a suitable weight to each VN related with the probability of an ANF to be excited. This probability is expressed by a cumulative beta distribution parameterized by two shape parameters that are calculated by means of a differential evolution algorithm (DE). Being the weights function of the current density, any change in the design of the CI affecting the current density produces changes in the weights and, therefore, in the simulated ECAP, which confers to our model a predictive capacity.<\/jats:p>\n<jats:p>The results of the validation with ECAP data from two patients are presented, achieving a satisfactory fit of the experimental data with those provided by the proposed computational model.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010134","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T17:39:49Z","timestamp":1653673189000},"page":"e1010134","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["A phenomenological computational model of the evoked action potential fitted to human cochlear implant responses"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-815X","authenticated-orcid":true,"given":"\u00c1ngel","family":"Ramos-de-Miguel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-7076","authenticated-orcid":true,"given":"Jos\u00e9 M.","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-7144","authenticated-orcid":true,"given":"David","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-2972","authenticated-orcid":true,"given":"Domingo","family":"Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-2971","authenticated-orcid":true,"given":"Eduardo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-8670","authenticated-orcid":true,"given":"Albert","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-2811","authenticated-orcid":true,"given":"Marcos","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-9244","authenticated-orcid":true,"given":"\u00c1ngel","family":"Ramos-Mac\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"pcbi.1010134.ref001","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1152\/jn.00149.2017","article-title":"Neurophisiology and neural engineering: a review","volume":"Vol. 118","author":"A Prochazka","year":"2017","journal-title":"Journal of Neurophysiology"},{"key":"pcbi.1010134.ref002","first-page":"1","article-title":"Cochlear Implant\u2014State of the Art, GMS Current Topics in Otorhinolaryngology","volume":"Vol. 16","author":"T Lenarz","year":"2017","journal-title":"Head and Neck Surgery"},{"key":"pcbi.1010134.ref003","first-page":"401","article-title":"Use of Electrically Evoked Compound Action Potentials for Cochlear Implant Fitting: A Systematic Review","volume":"vol. 39-3","author":"JJ de Vos","year":"2017","journal-title":"Ear and Hearing"},{"key":"pcbi.1010134.ref004","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.heares.2011.05.014","article-title":"Stimulus level effects on neural excitation and eCAP amplitude","volume":"280","author":"AA Westen","year":"2011","journal-title":"Hear. 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