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Recent work suggests that system-independent, quantitative features of the dynamics of gene expression can be used to identify core regulators. We introduce an approach of iterative network hypothesis reduction from time-series data in which increasingly complex features of the dynamic expression of individual, pairs, and entire collections of genes are used to infer functional network models that can produce the observed transcriptional program. The culmination of our work is a computational pipeline,\n                    <jats:bold>I<\/jats:bold>\n                    terative\n                    <jats:bold>N<\/jats:bold>\n                    etwork\n                    <jats:bold>H<\/jats:bold>\n                    ypoth\n                    <jats:bold>e<\/jats:bold>\n                    sis\n                    <jats:bold>Re<\/jats:bold>\n                    ductio\n                    <jats:bold>n<\/jats:bold>\n                    from\n                    <jats:bold>T<\/jats:bold>\n                    emporal\n                    <jats:bold>Dynamics<\/jats:bold>\n                    (Inherent dynamics pipeline), that provides a priority listing of targets for genetic perturbation to experimentally infer network structure. We demonstrate the capability of this integrated computational pipeline on synthetic and yeast cell-cycle data.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1010145","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T13:59:03Z","timestamp":1665410343000},"page":"e1010145","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Experimental guidance for discovering genetic networks through hypothesis reduction on time series"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-5277","authenticated-orcid":true,"given":"Breschine","family":"Cummins","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-5440","authenticated-orcid":true,"given":"Francis 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