{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:43:45Z","timestamp":1771379025341,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010159","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000}}],"reference-count":133,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["P50 DC015446"],"award-info":[{"award-number":["P50 DC015446"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["F31 DC014872"],"award-info":[{"award-number":["F31 DC014872"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["F32 DC017637"],"award-info":[{"award-number":["F32 DC017637"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 DC016270"],"award-info":[{"award-number":["R01 DC016270"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 DC002852"],"award-info":[{"award-number":["R01 DC002852"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008767","name":"Fundaci\u00f3n Agencia Aragonesa para la Investigaci\u00f3n y el Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 1191369"],"award-info":[{"award-number":["FONDECYT 1191369"]}],"id":[{"id":"10.13039\/501100008767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008767","name":"Fundaci\u00f3n Agencia Aragonesa para la Investigaci\u00f3n y el Desarrollo","doi-asserted-by":"publisher","award":["BASAL FB0008"],"award-info":[{"award-number":["BASAL FB0008"]}],"id":[{"id":"10.13039\/501100008767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Many voice disorders are the result of intricate neural and\/or biomechanical impairments that are poorly understood. The limited knowledge of their etiological and pathophysiological mechanisms hampers effective clinical management. Behavioral studies have been used concurrently with computational models to better understand typical and pathological laryngeal motor control. Thus far, however, a unified computational framework that quantitatively integrates physiologically relevant models of phonation with the neural control of speech has not been developed. Here, we introduce <jats:italic>LaDIVA<\/jats:italic>, a novel neurocomputational model with physiologically based laryngeal motor control. We combined the DIVA model (an established neural network model of speech motor control) with the extended body-cover model (a physics-based vocal fold model). The resulting integrated model, LaDIVA, was validated by comparing its model simulations with behavioral responses to perturbations of auditory vocal fundamental frequency (<jats:italic>f<\/jats:italic><jats:sub>o<\/jats:sub>) feedback in adults with typical speech. LaDIVA demonstrated capability to simulate different modes of laryngeal motor control, ranging from short-term (i.e., <jats:italic>reflexive<\/jats:italic>) and long-term (i.e., <jats:italic>adaptive<\/jats:italic>) auditory feedback paradigms, to generating prosodic contours in speech. Simulations showed that LaDIVA\u2019s laryngeal motor control displays properties of motor equivalence, i.e., LaDIVA could robustly generate compensatory responses to reflexive vocal <jats:italic>f<\/jats:italic><jats:sub>o<\/jats:sub> perturbations with varying initial laryngeal muscle activation levels leading to the same output. The model can also generate prosodic contours for studying laryngeal motor control in running speech. LaDIVA can expand the understanding of the physiology of human phonation to enable, for the first time, the investigation of causal effects of neural motor control in the fine structure of the vocal signal.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010159","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:48:57Z","timestamp":1656006537000},"page":"e1010159","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["LaDIVA: A neurocomputational model providing laryngeal motor control for speech acquisition and production"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-9104","authenticated-orcid":true,"given":"Hasini R.","family":"Weerathunge","sequence":"first","affiliation":[]},{"given":"Gabriel A.","family":"Alzamendi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-7336","authenticated-orcid":true,"given":"Gabriel J.","family":"Cler","sequence":"additional","affiliation":[]},{"given":"Frank H.","family":"Guenther","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8045-252X","authenticated-orcid":true,"given":"Cara E.","family":"Stepp","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-4392","authenticated-orcid":true,"given":"Mat\u00edas","family":"Za\u00f1artu","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"pcbi.1010159.ref001","article-title":"Voice disorders in teachers and the general population","author":"N Roy","year":"2004","journal-title":"Journal of Speech, Language, and Hearing Research"},{"issue":"4","key":"pcbi.1010159.ref002","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0892-1997(98)80058-1","article-title":"Vocal problems among teachers: a review of prevalence, causes, prevention, and treatment","volume":"12","author":"JA Mattiske","year":"1998","journal-title":"Journal of voice"},{"issue":"1","key":"pcbi.1010159.ref003","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/14015430119969","article-title":"Occupational risks for voice problems.","volume":"26","author":"K Verdolini","year":"2001","journal-title":"Logopedics Phoniatrics Vocology"},{"key":"pcbi.1010159.ref004","unstructured":"American Speech-Language-Hearing Association. Voice Disorders: (Practice Portal); n.d. [cited n.d.]. Available from: www.asha.org\/Practice-Portal\/Clinical-Topics\/Voice-Disorders\/."},{"key":"pcbi.1010159.ref005","volume-title":"Clinical voice pathology: Theory and management:","author":"JC Stemple","year":"2018"},{"key":"pcbi.1010159.ref006","doi-asserted-by":"crossref","DOI":"10.4324\/9781410617293","volume-title":"Classification manual for voice disorders-I:","author":"K Verdolini","year":"2014"},{"key":"pcbi.1010159.ref007","volume-title":"Preclinical speech science: Anatomy, physiology, acoustics, and perception","author":"TJ Hixon","year":"2018"},{"key":"pcbi.1010159.ref008","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/10471.001.0001","volume-title":"Neural control of speech:","author":"FH Guenther","year":"2016"},{"key":"pcbi.1010159.ref009","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.conb.2015.04.006","article-title":"The cortical computations underlying feedback control in vocal production","volume":"33","author":"JF Houde","year":"2015","journal-title":"Current opinion in neurobiology"},{"key":"pcbi.1010159.ref010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnhum.2011.00082","article-title":"Speech production as state feedback control","volume":"5","author":"JF Houde","year":"2011","journal-title":"Frontiers in human neuroscience"},{"issue":"3","key":"pcbi.1010159.ref011","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1121\/1.5092807","article-title":"Current models of speech motor control: A control-theoretic overview of architectures and properties","volume":"145","author":"B Parrell","year":"2019","journal-title":"The Journal of the Acoustical Society of America"},{"key":"pcbi.1010159.ref012","article-title":"Five decades of research in speech motor control: what have we learned, and where should we go from here? Journal of Speech, Language, and","author":"JS Perkell","year":"2013","journal-title":"Hearing Research"},{"issue":"3","key":"pcbi.1010159.ref013","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s10237-016-0863-5","article-title":"Modeling viscous dissipation during vocal fold contact: The influence of tissue viscosity and thickness with implications for hydration.","volume":"16","author":"BD Erath","year":"2017","journal-title":"Biomechanics and modeling in mechanobiology"},{"issue":"9","key":"pcbi.1010159.ref014","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1044\/2017_JSLHR-S-16-0412","article-title":"Modeling the pathophysiology of phonotraumatic vocal hyperfunction with a triangular glottal model of the vocal folds. Journal of Speech, Language, and","volume":"60","author":"GE Galindo","year":"2017","journal-title":"Hearing Research"},{"issue":"5","key":"pcbi.1010159.ref015","doi-asserted-by":"crossref","first-page":"EL434","DOI":"10.1121\/10.0001276","article-title":"Bayesian estimation of vocal function measures using laryngeal high-speed videoendoscopy and glottal airflow estimates: An in vivo case study","volume":"147","author":"GA Alzamendi","year":"2020","journal-title":"The Journal of the Acoustical Society of America"},{"key":"pcbi.1010159.ref016","first-page":"1419","article-title":"Estimation of subglottal pressure, vocal fold collision pressure, and intrinsic laryngeal muscle activation from neck-surface vibration using a neural network framework and a voice production model.","author":"EJ Ibarra","year":"2021","journal-title":"Frontiers in Physiology"},{"key":"pcbi.1010159.ref017","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/978-3-540-71505-4_4","volume-title":"Progress in Nonlinear Speech Processing:","author":"J Rouat","year":"2007"},{"key":"pcbi.1010159.ref018","first-page":"189","volume-title":"Plausible neural networks for biological modelling","author":"Springer","year":"2001"},{"issue":"2","key":"pcbi.1010159.ref019","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0093-934X(03)00345-6","article-title":"A new model of sensorimotor coupling in the development of speech","volume":"89","author":"G Westermann","year":"2004","journal-title":"Brain and language"},{"issue":"1","key":"pcbi.1010159.ref020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF00206237","article-title":"A neural network model of speech acquisition and motor equivalent speech production","volume":"72","author":"FH Guenther","year":"1994","journal-title":"Biological cybernetics"},{"issue":"3","key":"pcbi.1010159.ref021","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bandl.2005.06.001","article-title":"Neural modeling and imaging of the cortical interactions underlying syllable production","volume":"96","author":"FH Guenther","year":"2006","journal-title":"Brain and language"},{"issue":"4","key":"pcbi.1010159.ref022","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1037\/0033-295X.105.4.611-633","article-title":"A theoretical investigation of reference frames for the planning of speech movements.","volume":"105","author":"FH Guenther","year":"1998","journal-title":"Psychological review"},{"key":"pcbi.1010159.ref023","first-page":"1","article-title":"Modelling speech motor programming and apraxia of speech in the DIVA\/GODIVA neurocomputational framework.","author":"HE Miller","year":"2020","journal-title":"Aphasiology"},{"key":"pcbi.1010159.ref024","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jcomdis.2014.01.001","article-title":"Auditory\u2013motor interactions in pediatric motor speech disorders: Neurocomputational modeling of disordered development","volume":"47","author":"H Terband","year":"2014","journal-title":"Journal of Communication Disorders"},{"issue":"7","key":"pcbi.1010159.ref025","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1080\/01690960903498424","article-title":"The DIVA model: A neural theory of speech acquisition and production","volume":"26","author":"JA Tourville","year":"2011","journal-title":"Language and cognitive processes"},{"issue":"1","key":"pcbi.1010159.ref026","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2018.05.016","article-title":"The control of vocal pitch in human laryngeal motor cortex","volume":"174","author":"BK Dichter","year":"2018","journal-title":"Cell"},{"issue":"2","key":"pcbi.1010159.ref027","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/1073858410386727","article-title":"Laryngeal motor cortex and control of speech in humans.","volume":"17","author":"K Simonyan","year":"2011","journal-title":"The Neuroscientist"},{"issue":"6","key":"pcbi.1010159.ref028","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/000348949210100612","article-title":"Rapid voice tremor, or \u201cflutter,\u201d in amyotrophic lateral sclerosis.","volume":"101","author":"AE Aronson","year":"1992","journal-title":"Annals of Otology, Rhinology & Laryngology"},{"key":"pcbi.1010159.ref029","volume-title":"Motor speech disorders:","author":"FL Darley","year":"1975"},{"issue":"4","key":"pcbi.1010159.ref030","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0892-1997(05)80027-X","article-title":"Symptomatology of adductor spasmodic dysphonia: a physiologic model","volume":"6","author":"K. Izdebski","year":"1992","journal-title":"Journal of Voice"},{"issue":"12","key":"pcbi.1010159.ref031","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1177\/000348949510401203","article-title":"Abnormalities in long latency responses to superior laryngeal nerve stimulation in adductor spasmodic dysphonia.","volume":"104","author":"CL Ludlow","year":"1995","journal-title":"Annals of Otology, Rhinology & Laryngology"},{"issue":"2","key":"pcbi.1010159.ref032","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1044\/jshd.3902.169","article-title":"The core of the stuttering block","volume":"39","author":"MF Schwartz","year":"1974","journal-title":"Journal of Speech and Hearing Disorders"},{"issue":"5","key":"pcbi.1010159.ref033","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000263794","article-title":"Phonatory reflex mechanisms and stammering.","volume":"26","author":"B. Wyke","year":"1974","journal-title":"Folia Phoniatrica et Logopaedica"},{"issue":"6","key":"pcbi.1010159.ref034","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/mus.10503","article-title":"Laryngeal electromyography: an evidence-based review.","volume":"28","author":"ALET Force","year":"2003","journal-title":"Muscle & nerve"},{"issue":"3","key":"pcbi.1010159.ref035","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jvoice.2005.04.009","article-title":"The value of laryngeal electromyography in the evaluation of laryngeal motion abnormalities","volume":"20","author":"YD Heman-Ackah","year":"2006","journal-title":"Journal of Voice"},{"issue":"6","key":"pcbi.1010159.ref036","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1121\/1.3575593","article-title":"Laryngeal electromyographic responses to perturbations in voice pitch auditory feedback","volume":"129","author":"H Liu","year":"2011","journal-title":"The Journal of the Acoustical Society of America"},{"key":"pcbi.1010159.ref037","volume-title":"Laryngeal electromyography","author":"RT Sataloff","year":"2017"},{"issue":"3","key":"pcbi.1010159.ref038","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1044\/jshr.3403.473","article-title":"Laryngeal electromyographic activity in adductor and abductor spasmodic dysphonia.","volume":"34","author":"BC Watson","year":"1991","journal-title":"Journal of Speech, Language, and Hearing Research"},{"issue":"1","key":"pcbi.1010159.ref039","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00005537-199701000-00024","article-title":"Major patterns of laryngeal electromyography and their clinical application","volume":"107","author":"SS Yin","year":"1997","journal-title":"The Laryngoscope"},{"issue":"6","key":"pcbi.1010159.ref040","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MOO.0b013e3283585f04","article-title":"Current role of stroboscopy in laryngeal imaging","volume":"20","author":"DD Mehta","year":"2012","journal-title":"Current opinion in otolaryngology & head and neck surgery"},{"issue":"4","key":"pcbi.1010159.ref041","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0030-6665(05)70241-3","article-title":"Diagnostic laryngeal endoscopy.","volume":"33","author":"CA Rosen","year":"2000","journal-title":"Otolaryngologic Clinics of North America"},{"issue":"16","key":"pcbi.1010159.ref042","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.3390\/app11167256","article-title":"Direct Measurement and Modeling of Intraglottal, Subglottal, and Vocal Fold Collision Pressures during Phonation in an Individual with a Hemilaryngectomy.","volume":"11","author":"DD Mehta","year":"2021","journal-title":"Applied Sciences"},{"issue":"4","key":"pcbi.1010159.ref043","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1121\/1.4964509","article-title":"Mechanics of human voice production and control","volume":"140","author":"Z. Zhang","year":"2016","journal-title":"The journal of the acoustical society of america"},{"issue":"5","key":"pcbi.1010159.ref044","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1109\/TNSRE.2019.2906030","article-title":"Neurophysiological muscle activation scheme for controlling vocal fold models","volume":"27","author":"R Manr\u00edquez","year":"2019","journal-title":"IEEE Transactions on Neural Systems and Rehabilitation Engineering"},{"issue":"5","key":"pcbi.1010159.ref045","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.specom.2013.02.002","article-title":"A review of lumped-element models of voiced speech.","volume":"55","author":"BD Erath","year":"2013","journal-title":"Speech Communication"},{"issue":"2","key":"pcbi.1010159.ref046","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1121\/1.412234","article-title":"Voice simulation with a body-cover model of the vocal folds","volume":"97","author":"BH Story","year":"1995","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"2","key":"pcbi.1010159.ref047","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1121\/1.390530","article-title":"Parameterization of the glottal area, glottal flow, and vocal fold contact area","volume":"75","author":"IR Titze","year":"1984","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"3","key":"pcbi.1010159.ref048","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1121\/1.1496080","article-title":"Rules for controlling low-dimensional vocal fold models with muscle activation","volume":"112","author":"IR Titze","year":"2002","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"6","key":"pcbi.1010159.ref049","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1121\/1.4901714","article-title":"Modeling the effects of a posterior glottal opening on vocal fold dynamics with implications for vocal hyperfunction","volume":"136","author":"M Za\u00f1artu","year":"2014","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"6","key":"pcbi.1010159.ref050","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1121\/1.411449","article-title":"Theoretical and experimental study of quasisteady-flow separation within the glottis during phonation. Application to a modified two-mass model","volume":"96","author":"X Pelorson","year":"1994","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"5","key":"pcbi.1010159.ref051","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1121\/10.0005006","article-title":"Physics of phonation offset: Towards understanding relative fundamental frequency observations","volume":"149","author":"MA Serry","year":"2021","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"1","key":"pcbi.1010159.ref052","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1063\/1.166078","article-title":"Nonlinear dynamics of the voice: signal analysis and biomechanical modeling.","volume":"5","author":"H Herzel","year":"1995","journal-title":"Chaos: An Interdisciplinary Journal of Nonlinear Science"},{"issue":"3","key":"pcbi.1010159.ref053","doi-asserted-by":"crossref","first-page":"033113","DOI":"10.1063\/1.3615726","article-title":"Nonlinear vocal fold dynamics resulting from asymmetric fluid loading on a two-mass model of speech.","volume":"21","author":"BD Erath","year":"2011","journal-title":"Chaos: An Interdisciplinary Journal of Nonlinear Science"},{"issue":"1\u20135","key":"pcbi.1010159.ref054","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jsv.2008.02.026","article-title":"Nonlinear dynamic mechanism of vocal tremor from voice analysis and model simulations","volume":"316","author":"Y Zhang","year":"2008","journal-title":"Journal of sound and vibration"},{"issue":"4","key":"pcbi.1010159.ref055","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1121\/1.4865918","article-title":"Influence and interactions of laryngeal adductors and cricothyroid muscles on fundamental frequency and glottal posture control","volume":"135","author":"DK Chhetri","year":"2014","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"4","key":"pcbi.1010159.ref056","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1121\/10.0001093","article-title":"A three-dimensional vocal fold posturing model based on muscle mechanics and magnetic resonance imaging of a canine larynx","volume":"147","author":"B Geng","year":"2020","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"1","key":"pcbi.1010159.ref057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-92250-8","article-title":"Impaired auditory discrimination and auditory-motor integration in hyperfunctional voice disorders.","volume":"11","author":"D Abur","year":"2021","journal-title":"Scientific Reports"},{"issue":"9","key":"pcbi.1010159.ref058","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1002\/lary.27680","article-title":"Vocal motor control and central auditory impairments in unilateral vocal fold paralysis","volume":"129","author":"ML Naunheim","year":"2019","journal-title":"The Laryngoscope"},{"key":"pcbi.1010159.ref059","article-title":"Auditory Feedback Control of Vocal Pitch in Spasmodic Dysphonia","author":"A Thomas","year":"2020","journal-title":"The Laryngoscope"},{"issue":"6","key":"pcbi.1010159.ref060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jvoice.2018.07.001","article-title":"Control of fundamental frequency in dysphonic patients during phonation and speech","volume":"33","author":"A Ziethe","year":"2019","journal-title":"Journal of Voice"},{"issue":"6","key":"pcbi.1010159.ref061","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1121\/1.423073","article-title":"Voice F0 responses to manipulations in pitch feedback","volume":"103","author":"TA Burnett","year":"1998","journal-title":"J Acoust Soc Am"},{"issue":"2","key":"pcbi.1010159.ref062","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0892-1997(97)80079-3","article-title":"Voice F0 responses to pitch-shifted auditory feedback: a preliminary study.","volume":"11","author":"TA Burnett","year":"1997","journal-title":"J Voice"},{"issue":"2","key":"pcbi.1010159.ref063","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s002219900237","article-title":"Instructing subjects to make a voluntary response reveals the presence of two components to the audio-vocal reflex","volume":"130","author":"TC Hain","year":"2000","journal-title":"Experimental Brain Research"},{"issue":"1","key":"pcbi.1010159.ref064","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1121\/1.428323","article-title":"Effects of pitch-shift velocity on voice F 0 responses","volume":"107","author":"CR Larson","year":"2000","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"3","key":"pcbi.1010159.ref065","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00221-008-1473-y","article-title":"Auditory-motor mapping for pitch control in singers and nonsingers","volume":"190","author":"JA Jones","year":"2008","journal-title":"Experimental brain research"},{"issue":"19","key":"pcbi.1010159.ref066","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.cub.2005.08.063","article-title":"Remapping auditory-motor representations in voice production","volume":"15","author":"JA Jones","year":"2005","journal-title":"Current biology"},{"issue":"1","key":"pcbi.1010159.ref067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-14-25","article-title":"Auditory-motor adaptation to frequency-altered auditory feedback occurs when participants ignore feedback","volume":"14","author":"D Keough","year":"2013","journal-title":"BMC neuroscience"},{"issue":"11","key":"pcbi.1010159.ref068","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1044\/2020_JSLHR-20-00192","article-title":"The Relation of Articulatory and Vocal Auditory\u2013Motor Control in Typical Speakers.","volume":"63","author":"RA Lester-Smith","year":"2020","journal-title":"Journal of Speech, Language, and Hearing Research"},{"issue":"1","key":"pcbi.1010159.ref069","doi-asserted-by":"crossref","first-page":"e0191839","DOI":"10.1371\/journal.pone.0191839","article-title":"Sensorimotor adaptation of voice fundamental frequency in Parkinson\u2019s disease.","volume":"13","author":"D Abur","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"pcbi.1010159.ref070","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1044\/2017_JSLHR-S-16-0282","article-title":"Evidence for Auditory-Motor Impairment in Individuals With Hyperfunctional Voice Disorders.","volume":"60","author":"CE Stepp","year":"2017","journal-title":"J Speech Lang Hear Res"},{"issue":"6","key":"pcbi.1010159.ref071","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jvoice.2018.07.001","article-title":"Control of Fundamental Frequency in Dysphonic Patients During Phonation and Speech.","volume":"33","author":"A Ziethe","year":"2019","journal-title":"J Voice"},{"key":"pcbi.1010159.ref072","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainres.2013.06.030","article-title":"Sensorimotor control of vocal pitch production in Parkinson\u2019s disease","volume":"1527","author":"X Chen","year":"2013","journal-title":"Brain Research"},{"issue":"3","key":"pcbi.1010159.ref073","doi-asserted-by":"crossref","first-page":"e33629","DOI":"10.1371\/journal.pone.0033629","article-title":"Vocal responses to perturbations in voice auditory feedback in individuals with Parkinson\u2019s disease.","volume":"7","author":"H Liu","year":"2012","journal-title":"PloS one"},{"key":"pcbi.1010159.ref074","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.brainres.2016.06.013","article-title":"Sensorimotor control of vocal pitch and formant frequencies in Parkinson\u2019s disease","volume":"1646","author":"F Mollaei","year":"2016","journal-title":"Brain research"},{"issue":"12","key":"pcbi.1010159.ref075","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1044\/2019_JSLHR-S-18-0425","article-title":"The relationship between speech perceptual discrimination and speech production in Parkinson\u2019s disease.","volume":"62","author":"F Mollaei","year":"2019","journal-title":"Journal of Speech, Language, and Hearing Research"},{"key":"pcbi.1010159.ref076","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.3389\/fpsyg.2019.02995","article-title":"A simple 3-parameter model for examining adaptation in speech and voice production.","volume":"10","author":"E Kearney","year":"2020","journal-title":"Frontiers in psychology"},{"issue":"1985","key":"pcbi.1010159.ref077","first-page":"1","article-title":"A four-parameter model of glottal flow.","volume":"4","author":"G Fant","year":"1985","journal-title":"STL-QPSR"},{"issue":"3\u20134","key":"pcbi.1010159.ref078","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0167-6393(82)90017-6","article-title":"A digital simulation method of the vocal-tract system","volume":"1","author":"S. Maeda","year":"1982","journal-title":"Speech communication"},{"issue":"2","key":"pcbi.1010159.ref079","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000263771","article-title":"Morphological structure of the vocal cord as a vibrator and its variations","volume":"26","author":"M. Hirano","year":"1974","journal-title":"Folia Phoniatrica et Logopaedica"},{"issue":"1","key":"pcbi.1010159.ref080","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1044\/jslhr.4301.268","article-title":"Short-latency changes in voice F0 and neck surface EMG induced by mechanical perturbations of the larynx during sustained vowel phonation.","volume":"43","author":"S Sapir","year":"2000","journal-title":"Journal of Speech, Language, and Hearing Research"},{"issue":"5","key":"pcbi.1010159.ref081","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/lary.25550","article-title":"Interactions of subglottal pressure and neuromuscular activation on fundamental frequency and intensity","volume":"126","author":"DK Chhetri","year":"2016","journal-title":"The Laryngoscope"},{"issue":"1","key":"pcbi.1010159.ref082","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1121\/10.0005275","article-title":"Effects of cricothyroid and thyroarytenoid interaction on voice control: Muscle activity, vocal fold biomechanics, flow, and acoustics","volume":"150","author":"M Movahhedi","year":"2021","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"2","key":"pcbi.1010159.ref083","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1121\/10.0005883","article-title":"Vocal fold vibration mode changes due to cricothyroid and thyroarytenoid muscle interaction in a three-dimensional model of the canine larynx","volume":"150","author":"B Geng","year":"2021","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"2","key":"pcbi.1010159.ref084","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1121\/1.2404624","article-title":"Voice F 0 responses to pitch-shifted voice feedback during English speech","volume":"121","author":"SH Chen","year":"2007","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"7","key":"pcbi.1010159.ref085","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1044\/2020_JSLHR-19-00043","article-title":"The effect of pitch auditory feedback perturbations on the production of anticipatory phrasal prominence and boundary.","volume":"63","author":"A Hilger","year":"2020","journal-title":"Journal of Speech, Language, and Hearing Research"},{"key":"pcbi.1010159.ref086","author":"R Patel","year":"2011","journal-title":"Prosodic adaptations to pitch perturbation in running speech"},{"issue":"6S","key":"pcbi.1010159.ref087","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1044\/2021_JSLHR-20-00278","article-title":"Speech Intensity Response to Altered Intensity Feedback in Individuals With Parkinson\u2019s Disease.","volume":"64","author":"A Senthinathan","year":"2021","journal-title":"J Speech Lang Hear Res"},{"issue":"3","key":"pcbi.1010159.ref088","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1044\/2018_AJSLP-17-0009","article-title":"Recommended Protocols for Instrumental Assessment of Voice: American Speech-Language-Hearing Association Expert Panel to Develop a Protocol for Instrumental Assessment of Vocal Function.","volume":"27","author":"RR Patel","year":"2018","journal-title":"Am J Speech Lang Pathol."},{"key":"pcbi.1010159.ref089","volume-title":"Understanding voice problems: A physiological perspective for diagnosis and treatment:","author":"JK Casper","year":"2006"},{"key":"pcbi.1010159.ref090","first-page":"1","article-title":"An Updated Theoretical Framework for Vocal Hyperfunction.","author":"RE Hillman","year":"2020","journal-title":"American Journal of Speech-Language Pathology"},{"issue":"8","key":"pcbi.1010159.ref091","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1044\/2017_JSLHR-S-16-0337","article-title":"Glottal aerodynamic measures in women with phonotraumatic and nonphonotraumatic vocal hyperfunction.","volume":"60","author":"VM Espinoza","year":"2017","journal-title":"Journal of Speech, Language, and Hearing Research."},{"key":"pcbi.1010159.ref092","volume-title":"Perceptual correlates of acoustic measures of vocal variability:","author":"BA Cumbers","year":"2013"},{"key":"pcbi.1010159.ref093","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-neuro-072116-031548","article-title":"The role of variability in motor learning","volume":"40","author":"AK Dhawale","year":"2017","journal-title":"Annual review of neuroscience"},{"issue":"2","key":"pcbi.1010159.ref094","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neulet.2012.09.012","article-title":"The relationship between vocal accuracy and variability to the level of compensation to altered auditory feedback","volume":"529","author":"NE Scheerer","year":"2012","journal-title":"Neuroscience letters"},{"key":"pcbi.1010159.ref095","first-page":"1","article-title":"A Computational Model for Estimating the Speech Motor System\u2019s Sensitivity to Auditory Prediction Errors.","author":"A. Daliri","year":"2021","journal-title":"Journal of Speech, Language, and Hearing Research"},{"key":"pcbi.1010159.ref096","article-title":"Triangular body-cover model of the vocal folds with coordinated activation of five intrinsic laryngeal muscles with applications to vocal hyperfunction.","author":"GA Alzamendi","year":"2021","journal-title":"arXiv preprint arXiv:210801115"},{"issue":"6","key":"pcbi.1010159.ref097","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1121\/1.2800254","article-title":"Effects of perturbation magnitude and voice F 0 level on the pitch-shift reflex","volume":"122","author":"H Liu","year":"2007","journal-title":"The Journal of the Acoustical Society of America"},{"key":"pcbi.1010159.ref098","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuropsychologia.2017.12.007","article-title":"Detecting our own vocal errors: An event-related study of the thresholds for perceiving and compensating for vocal pitch errors.","volume":"114","author":"NE Scheerer","year":"2018","journal-title":"Neuropsychologia"},{"issue":"2","key":"pcbi.1010159.ref099","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/JBCPP.2001.12.2.125","article-title":"Pitch discrimination: Are professional musicians better than non-musicians?","volume":"12","author":"L Kishon-Rabin","year":"2001","journal-title":"Journal of basic and clinical physiology and pharmacology"},{"issue":"1","key":"pcbi.1010159.ref100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00221-004-2044-5","article-title":"Pitch discrimination accuracy in musicians vs nonmusicians: an event-related potential and behavioral study.","volume":"161","author":"M Tervaniemi","year":"2005","journal-title":"Experimental brain research"},{"key":"pcbi.1010159.ref101","doi-asserted-by":"crossref","DOI":"10.1044\/1058-0360(2012\/11-0007)","article-title":"Tone discrimination as a window into acoustic perceptual deficits in Parkinson\u2019s disease.","author":"J Troche","year":"2012"},{"key":"pcbi.1010159.ref102","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnhum.2018.00091","article-title":"Online adaptation to altered auditory feedback is predicted by auditory acuity and not by domain-general executive control resources","volume":"12","author":"CD Martin","year":"2018","journal-title":"Frontiers in Human Neuroscience"},{"issue":"4","key":"pcbi.1010159.ref103","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1121\/1.4778207","article-title":"Relations between speech sensorimotor adaptation and perceptual acuity","volume":"117","author":"V Villacorta","year":"2005","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"4","key":"pcbi.1010159.ref104","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1121\/1.2773966","article-title":"Sensorimotor adaptation to feedback perturbations of vowel acoustics and its relation to perception","volume":"122","author":"VM Villacorta","year":"2007","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"1","key":"pcbi.1010159.ref105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-73932-1","article-title":"Adaptation to pitch-altered feedback is independent of one\u2019s own voice pitch sensitivity.","volume":"10","author":"R Alemi","year":"2020","journal-title":"Scientific reports"},{"issue":"1","key":"pcbi.1010159.ref106","first-page":"1","article-title":"Relationships between vocal pitch perception and production: A developmental perspective.","volume":"10","author":"ESH Murray","year":"2020","journal-title":"Scientific reports"},{"issue":"3\u20134","key":"pcbi.1010159.ref107","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/00016488609108682","article-title":"Glottal Adjustment for Regulating Vocal Intensity An Experimental Study.","volume":"102","author":"S Tanaka","year":"1986","journal-title":"Acta oto-laryngologica"},{"key":"pcbi.1010159.ref108","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.csl.2016.06.004","article-title":"Manipulation of the prosodic features of vocal tract length, nasality and articulatory precision using articulatory synthesis.","volume":"41","author":"P Birkholz","year":"2017","journal-title":"Computer Speech & Language"},{"issue":"1","key":"pcbi.1010159.ref109","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/1059712309350972","article-title":"Computer models of vocal tract evolution: An overview and critique","volume":"18","author":"B De Boer","year":"2010","journal-title":"Adaptive Behavior"},{"issue":"4","key":"pcbi.1010159.ref110","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00221-008-1330-z","article-title":"Interactions between auditory and somatosensory feedback for voice F 0 control","volume":"187","author":"CR Larson","year":"2008","journal-title":"Experimental brain research"},{"issue":"3","key":"pcbi.1010159.ref111","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000264125","article-title":"Sensory contributions to control of fundamental frequency of phonation.","volume":"30","author":"A Mallard","year":"1978","journal-title":"Folia Phoniatrica et Logopaedica"},{"issue":"5354","key":"pcbi.1010159.ref112","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1126\/science.279.5354.1213","article-title":"Sensorimotor adaptation in speech production","volume":"279","author":"JF Houde","year":"1998","journal-title":"Science"},{"issue":"3","key":"pcbi.1010159.ref113","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1121\/1.1487844","article-title":"Early pitch-shift response is active in both steady and dynamic voice pitch control","volume":"112","author":"TA Burnett","year":"2002","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"3","key":"pcbi.1010159.ref114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00221-008-1529-z","article-title":"Reflexive and volitional voice fundamental frequency responses to an anticipated feedback pitch error","volume":"191","author":"TA Burnett","year":"2008","journal-title":"Experimental brain research"},{"issue":"1","key":"pcbi.1010159.ref115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1121\/1.1424870","article-title":"Effects of frequency-shifted auditory feedback on voice F 0 contours in syllables","volume":"111","author":"TM Donath","year":"2002","journal-title":"The Journal of the Acoustical Society of America"},{"key":"pcbi.1010159.ref116","author":"S Kiran","year":"2001","journal-title":"Effect of duration of pitch-shifted feedback on vocal responses in patients with Parkinson\u2019s disease"},{"issue":"2","key":"pcbi.1010159.ref117","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1121\/1.1849933","article-title":"Voice responses to changes in pitch of voice or tone auditory feedback","volume":"117","author":"M Sivasankar","year":"2005","journal-title":"The Journal of the Acoustical Society of America"},{"key":"pcbi.1010159.ref118","first-page":"71","article-title":"Neuromuscular control systems in voice production","author":"B. Wyke","year":"1983","journal-title":"Vocal fold physiology: Contemporary research and clinical issues"},{"issue":"4","key":"pcbi.1010159.ref119","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000263784","article-title":"Laryngeal myotatic reflexes and phonation.","volume":"26","author":"BD Wyke","year":"1974","journal-title":"Folia Phoniatrica et Logopaedica"},{"issue":"1","key":"pcbi.1010159.ref120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00221-013-3703-1","article-title":"Voice-related modulation of mechanosensory detection thresholds in the human larynx","volume":"232","author":"MJ Hammer","year":"2014","journal-title":"Experimental brain research"},{"issue":"2","key":"pcbi.1010159.ref121","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1152\/jn.00638.2010","article-title":"Integration of auditory and somatosensory error signals in the neural control of speech movements","volume":"106","author":"Y Feng","year":"2011","journal-title":"Journal of neurophysiology"},{"issue":"27","key":"pcbi.1010159.ref122","doi-asserted-by":"crossref","first-page":"9351","DOI":"10.1523\/JNEUROSCI.0404-12.2012","article-title":"Sensory preference in speech production revealed by simultaneous alteration of auditory and somatosensory feedback","volume":"32","author":"DR Lametti","year":"2012","journal-title":"Journal of Neuroscience"},{"issue":"6","key":"pcbi.1010159.ref123","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/000348940911800608","article-title":"Quantifying vocal fatigue recovery: dynamic vocal recovery trajectories after a vocal loading exercise.","volume":"118","author":"EJ Hunter","year":"2009","journal-title":"Annals of Otology, Rhinology & Laryngology"},{"issue":"2","key":"pcbi.1010159.ref124","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/000348948309200209","article-title":"Vocal fatigue.","volume":"92","author":"EK Sander","year":"1983","journal-title":"Annals of Otology, Rhinology & Laryngology"},{"issue":"1","key":"pcbi.1010159.ref125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0892-1997(03)00033-X","article-title":"Vocal fatigue: current knowledge and future directions","volume":"17","author":"NV Welham","year":"2003","journal-title":"Journal of voice"},{"issue":"7","key":"pcbi.1010159.ref126","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1440-1622.1999.01613.x","article-title":"Unilateral vocal fold paralysis: causes, options and outcomes","volume":"69","author":"T Havas","year":"1999","journal-title":"Australian and New Zealand journal of surgery"},{"issue":"5","key":"pcbi.1010159.ref127","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.otc.2012.06.011","article-title":"Evidence-based practice: evaluation and management of unilateral vocal fold paralysis.","volume":"45","author":"S Misono","year":"2012","journal-title":"Otolaryngologic Clinics of North America"},{"issue":"6","key":"pcbi.1010159.ref128","doi-asserted-by":"crossref","first-page":"EL355","DOI":"10.1121\/1.3509124","article-title":"Sex-related differences in vocal responses to pitch feedback perturbations during sustained vocalization","volume":"128","author":"Z Chen","year":"2010","journal-title":"J Acoust Soc Am"},{"issue":"7","key":"pcbi.1010159.ref129","doi-asserted-by":"crossref","first-page":"e0219914","DOI":"10.1371\/journal.pone.0219914","article-title":"An acoustic source model for asymmetric intraglottal flow with application to reduced-order models of the vocal folds.","volume":"14","author":"BD Erath","year":"2019","journal-title":"PloS one"},{"key":"pcbi.1010159.ref130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jbiomech.2018.04.011","article-title":"Vocal fold contact patterns based on normal modes of vibration","volume":"73","author":"SL Smith","year":"2018","journal-title":"Journal of biomechanics"},{"issue":"2","key":"pcbi.1010159.ref131","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1121\/1.2409491","article-title":"Influence of acoustic loading on an effective single mass model of the vocal folds","volume":"121","author":"M Zanartu","year":"2007","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"4","key":"pcbi.1010159.ref132","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1121\/1.389235","article-title":"Relationships between vocal intensity and noninvasively obtained aerodynamic parameters in normal subjects","volume":"73","author":"S Tanaka","year":"1983","journal-title":"The Journal of the Acoustical Society of America"},{"issue":"4","key":"pcbi.1010159.ref133","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1121\/1.2832339","article-title":"Nonlinear source\u2013filter coupling in phonation: Theory","volume":"123","author":"IR Titze","year":"2008","journal-title":"The Journal of the Acoustical Society of America"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1010159","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1010159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T17:54:05Z","timestamp":1657130045000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1010159"}},"subtitle":[],"editor":[{"given":"Fr\u00e9d\u00e9ric E.","family":"Theunissen","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2022,6,23]]},"references-count":133,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1010159","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1010159","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,23]]}}}