{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:16:47Z","timestamp":1774685807186,"version":"3.50.1"},"reference-count":159,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES023770"],"award-info":[{"award-number":["ES023770"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES007322"],"award-info":[{"award-number":["ES007322"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"national institute of general medical sciences","doi-asserted-by":"crossref","award":["U01GM110748"],"award-info":[{"award-number":["U01GM110748"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Given the crucial role of climate in malaria transmission, many mechanistic models of malaria represent vector biology and the parasite lifecycle as functions of climate variables in order to accurately capture malaria transmission dynamics. Lower dimension mechanistic models that utilize implicit vector dynamics have relied on indirect climate modulation of transmission processes, which compromises investigation of the ecological role played by climate in malaria transmission. In this study, we develop an implicit process-based malaria model with direct climate-mediated modulation of transmission pressure borne through the Entomological Inoculation Rate (EIR). The EIR, a measure of the number of infectious bites per person per unit time, includes the effects of vector dynamics, resulting from mosquito development, survivorship, feeding activity and parasite development, all of which are moderated by climate. We combine this EIR-model framework, which is driven by rainfall and temperature, with Bayesian inference methods, and evaluate the model\u2019s ability to simulate local transmission across 42 regions in Rwanda over four years. Our findings indicate that the biologically-motivated, EIR-model framework is capable of accurately simulating seasonal malaria dynamics and capturing of some of the inter-annual variation in malaria incidence. However, the model unsurprisingly failed to reproduce large declines in malaria transmission during 2018 and 2019 due to elevated anti-malaria measures, which were not accounted for in the model structure. The climate-driven transmission model also captured regional variation in malaria incidence across Rwanda\u2019s diverse climate, while identifying key entomological and epidemiological parameters important to seasonal malaria dynamics. In general, this new model construct advances the capabilities of implicitly-forced lower dimension dynamical malaria models by leveraging climate drivers of malaria ecology and transmission.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010161","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T17:27:49Z","timestamp":1654795669000},"page":"e1010161","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inference and dynamic simulation of malaria using a simple climate-driven entomological model of malaria transmission"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-4229","authenticated-orcid":true,"given":"Israel","family":"Ukawuba","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-7809","authenticated-orcid":true,"given":"Jeffrey","family":"Shaman","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"pcbi.1010161.ref001","author":"World Health Organization","year":"2019"},{"key":"pcbi.1010161.ref002","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0140-6736(10)61500-0","article-title":"Call to action: priorities for malaria elimination","volume":"376","author":"RGA Feachem","year":"2010","journal-title":"Lancet"},{"key":"pcbi.1010161.ref003","first-page":"341","article-title":"Drug-resistant malaria\u2014occurrence, control, and surveillance","volume":"58","author":"WH Wernsdorfer","year":"1980","journal-title":"Bull World Health Organ"},{"key":"pcbi.1010161.ref004","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/S0140-6736(10)61270-6","article-title":"Shrinking the malaria map: progress and prospects","volume":"376","author":"RG Feachem","year":"2010","journal-title":"Lancet"},{"key":"pcbi.1010161.ref005","first-page":"501","article-title":"Roll Back Malaria.","volume":"41","author":"D. Nabarro","year":"1999","journal-title":"Parassitologia"},{"key":"pcbi.1010161.ref006","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/S0140-6736(18)30911-5","article-title":"The Lancet Commission on malaria eradication","volume":"391","author":"I Chen","year":"2018","journal-title":"The Lancet"},{"key":"pcbi.1010161.ref007","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.0269-283X.2004.00495.x","article-title":"Temperature-related duration of aquatic stages of the Afrotropical malaria vector mosquito Anopheles gambiae in the laboratory","volume":"18","author":"MN Bayoh","year":"2004","journal-title":"Med Vet Entomol"},{"key":"pcbi.1010161.ref008","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1079\/BER2003259","article-title":"Effect of temperature on the development of the aquatic stages of Anopheles gambiae sensu stricto (Diptera: Culicidae)","volume":"93","author":"MN Bayoh","year":"2003","journal-title":"Bull Entomol 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East African highland","volume":"278","author":"D Alonso","year":"2011","journal-title":"Proc R Soc B Biol Sci."},{"key":"pcbi.1010161.ref013","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1475-2875-3-32","article-title":"A weather-driven model of malaria transmission.","volume":"3","author":"MB Hoshen","year":"2004","journal-title":"Malar J"},{"key":"pcbi.1010161.ref014","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1175\/2010JCLI3208.1","article-title":"Application and Validation of a Seasonal Ensemble Prediction System Using a Dynamic Malaria Model","volume":"23","author":"AE Jones","year":"2010","journal-title":"J Clim."},{"key":"pcbi.1010161.ref015","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1137\/080744438","article-title":"A Climate-Based Malaria Transmission Model with Structured Vector Population.","volume":"70","author":"Y Lou","year":"2010","journal-title":"SIAM J Appl Math."},{"key":"pcbi.1010161.ref016","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1475-2875-12-65","article-title":"A regional-scale, high resolution dynamical malaria model that accounts for population density, climate and surface hydrology.","volume":"12","author":"AM Tompkins","year":"2013","journal-title":"Malar J"},{"key":"pcbi.1010161.ref017","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1198\/jasa.2011.ap10323","article-title":"Malaria in Northwest India: Data Analysis via Partially Observed Stochastic Differential Equation Models Driven by L\u00e9vy Noise","volume":"106","author":"A Bhadra","year":"2011","journal-title":"J Am Stat Assoc."},{"key":"pcbi.1010161.ref018","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1475-2875-8-61","article-title":"Modelling malaria incidence with environmental dependency in a locality of Sudanese savannah area, Mali.","volume":"8","author":"J Gaudart","year":"2009","journal-title":"Malar 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II. Calibration and validation for West Africa","volume":"10","author":"V Ermert","year":"2011","journal-title":"Malar J"},{"key":"pcbi.1010161.ref026","first-page":"e595948","article-title":"A Vectorial Capacity Product to Monitor Changing Malaria Transmission Potential in Epidemic Regions of Africa, A Vectorial Capacity Product to Monitor Changing Malaria Transmission Potential in Epidemic Regions of Africa.","volume":"2012","author":"P Ceccato","year":"2012","journal-title":"J Trop Med J Trop Med"},{"key":"pcbi.1010161.ref027","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/ele.12015","article-title":"Optimal temperature for malaria transmission is dramatically lower than previously predicted","volume":"16","author":"EA Mordecai","year":"2013","journal-title":"Ecol Lett"},{"key":"pcbi.1010161.ref028","doi-asserted-by":"crossref","first-page":"14592","DOI":"10.1038\/ncomms14592","article-title":"Ensemble forecast of human West Nile virus cases and mosquito infection rates.","volume":"8","author":"NB DeFelice","year":"2017","journal-title":"Nat Commun"},{"key":"pcbi.1010161.ref029","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1038\/ncomms3837","article-title":"Real-Time Influenza Forecasts during the 2012\u20132013 Season","volume":"4","author":"J Shaman","year":"2013","journal-title":"Nat Commun."},{"key":"pcbi.1010161.ref030","doi-asserted-by":"crossref","first-page":"20425","DOI":"10.1073\/pnas.1208772109","article-title":"Forecasting seasonal outbreaks of influenza","volume":"109","author":"J Shaman","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"pcbi.1010161.ref031","doi-asserted-by":"crossref","first-page":"e1003583","DOI":"10.1371\/journal.pcbi.1003583","article-title":"Comparison of Filtering Methods for the Modeling and Retrospective Forecasting of Influenza Epidemics","volume":"10","author":"W Yang","year":"2014","journal-title":"PLOS Comput Biol."},{"key":"pcbi.1010161.ref032","volume-title":"Final Report.","author":"U.S. President\u2019s Malaria Initiative","year":"2017"},{"key":"pcbi.1010161.ref033","volume-title":"Final Report.","author":"U.S. President\u2019s Malaria Initiative","year":"2018"},{"key":"pcbi.1010161.ref034","volume-title":"Final Report.","author":"U.S. President\u2019s Malaria Initiative","year":"2019"},{"key":"pcbi.1010161.ref035","volume-title":"Final Report.","author":"U.S. President\u2019s Malaria Initiative","year":"2020"},{"key":"pcbi.1010161.ref036","volume-title":"Rwanda Biomedical Center","author":"Ministry of Health, Rwanda","year":"2017"},{"key":"pcbi.1010161.ref037","volume-title":"Rwanda Malaria Operational Plan FY 2018. USAID.","author":"U.S. President\u2019s Malaria Initiative","year":"2018"},{"key":"pcbi.1010161.ref038","volume-title":"Rwanda Malaria Operational Plan FY 2019.","author":"U.S. President\u2019s Malaria Initiative","year":"2019"},{"key":"pcbi.1010161.ref039","article-title":"History of malaria control in Rwanda: implications for future elimination in Rwanda and other malaria-endemic countries.","volume":"19","author":"C Karema","year":"2020","journal-title":"Malar J [Internet]."},{"key":"pcbi.1010161.ref040","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/1756-3305-7-383","article-title":"Preventive effect of permethrin-impregnated long-lasting insecticidal nets on the blood feeding of three major pyrethroid-resistant malaria vectors in western Kenya","volume":"7","author":"H Kawada","year":"2014","journal-title":"Parasit Vectors"},{"key":"pcbi.1010161.ref041","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2915.1987.tb00361.x","article-title":"The effect of permethrin-impregnated bednets on a population of Anopheles farauti in coastal Papua New Guinea","volume":"1","author":"JD Charlwood","year":"1987","journal-title":"Med Vet Entomol"},{"key":"pcbi.1010161.ref042","article-title":"The ability of Anopheles gambiae mosquitoes to bite through a permethrin-treated net and the consequences for their fitness.","author":"G Hauser","year":"2019","journal-title":"undefined [Internet]"},{"key":"pcbi.1010161.ref043","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/1471-2334-13-428","article-title":"Population-level effects of clinical immunity to malaria","volume":"13","author":"LT Keegan","year":"2013","journal-title":"BMC Infect Dis"},{"key":"pcbi.1010161.ref044","article-title":"Loss of Population Levels of Immunity to Malaria as a Result of Exposure-Reducing Interventions: Consequences for Interpretation of Disease Trends.","author":"AC Ghani","year":"2009","journal-title":"PLoS ONE [Internet]."},{"key":"pcbi.1010161.ref045","doi-asserted-by":"crossref","first-page":"845","DOI":"10.4269\/ajtmh.1937.s1-17.845","article-title":"The Duration of the Intrinsic Incubation Period in Falciparum Malaria in Relation to Certain Factors Affecting the Parasites1","volume":"s1-17","author":"MF Boyd","year":"1937","journal-title":"Am J Trop Med Hyg"},{"key":"pcbi.1010161.ref046","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/s41467-019-09441-1","article-title":"The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density","volume":"10","author":"HC Slater","year":"2019","journal-title":"Nat Commun."},{"key":"pcbi.1010161.ref047","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/cid\/cix1123","article-title":"The Relative Contribution of Symptomatic and Asymptomatic Plasmodium vivax and Plasmodium falciparum Infections to the Infectious Reservoir in a Low-Endemic Setting in Ethiopia","volume":"66","author":"FG Tadesse","year":"2018","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"pcbi.1010161.ref048","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1586\/eri.13.45","article-title":"The silent threat: asymptomatic parasitemia and malaria transmission.","volume":"11","author":"KA Lindblade","year":"2013","journal-title":"Expert Rev Anti Infect Ther"},{"key":"pcbi.1010161.ref049","doi-asserted-by":"crossref","first-page":"e45542","DOI":"10.1371\/journal.pone.0045542","article-title":"The Dynamics of Natural Plasmodium falciparum Infections","volume":"7","author":"I Felger","year":"2012","journal-title":"PLOS ONE."},{"key":"pcbi.1010161.ref050","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1371\/journal.pcbi.0030255","article-title":"Determination of the Processes Driving the Acquisition of Immunity to Malaria Using a Mathematical Transmission Model.","volume":"3","author":"JAN Filipe","year":"2007","journal-title":"PLOS Comput Biol."},{"key":"pcbi.1010161.ref051","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/6560","article-title":"Immunity to non-cerebral severe malaria is acquired after one or two infections","volume":"5","author":"S Gupta","year":"1999","journal-title":"Nat Med."},{"key":"pcbi.1010161.ref052","article-title":"National Institute of Statistics of Rwanda","year":"2015","journal-title":"Rwanda Demographic and Health Survey 2014\u201315"},{"key":"pcbi.1010161.ref053","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0035-9203(00)90246-3","article-title":"Annual Plasmodium falciparum entomological inoculation rates (EIR) across Africa: literature survey, internet access and review","volume":"94","author":"SI Hay","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pcbi.1010161.ref054","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s12936-015-0864-3","article-title":"Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment","volume":"14","author":"MA Penny","year":"2015","journal-title":"Malar J."},{"key":"pcbi.1010161.ref055","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actatropica.2018.02.012","article-title":"Spatio-temporal distribution of mosquitoes and risk of malaria infection in Rwanda","volume":"182","author":"E Hakizimana","year":"2018","journal-title":"Acta Trop"},{"key":"pcbi.1010161.ref056","author":"National Institute of Statistics of Rwanda","year":"2012"},{"key":"pcbi.1010161.ref057","volume-title":"Rwanda Demographic and Health Survey 2014\u201315","author":"National Institute of Statistics of Rwanda","year":"2015"},{"key":"pcbi.1010161.ref058","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ni.f.205","article-title":"Immunity to malaria: more questions than answers","volume":"9","author":"J Langhorne","year":"2008","journal-title":"Nat Immunol."},{"key":"pcbi.1010161.ref059","doi-asserted-by":"crossref","first-page":"064015","DOI":"10.1088\/1748-9326\/aa64e6","article-title":"Temperature suitability for malaria climbing the Ethiopian Highlands","volume":"12","author":"B Lyon","year":"2017","journal-title":"Environ Res Lett."},{"key":"pcbi.1010161.ref060","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12936-016-1362-y","article-title":"Factors associated with high heterogeneity of malaria at fine spatial scale in the Western Kenyan highlands","volume":"15","author":"AY Baidjoe","year":"2016","journal-title":"Malar J"},{"key":"pcbi.1010161.ref061","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1475-2875-5-78","article-title":"Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors.","volume":"5","author":"KC Ernst","year":"2006","journal-title":"Malar J"},{"key":"pcbi.1010161.ref062","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-3156.2004.01272.x","article-title":"Spatial clustering of malaria and associated risk factors during an epidemic in a highland area of western Kenya","volume":"9","author":"S Brooker","year":"2004","journal-title":"Trop Med Int Health"},{"key":"pcbi.1010161.ref063","first-page":"613","article-title":"Epidemiological basis of malaria control","volume":"15","author":"G. Macdonald","year":"1956","journal-title":"Bull World Health Organ"},{"key":"pcbi.1010161.ref064","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/trstmh\/trv113","article-title":"Vectorial capacity and vector control: reconsidering sensitivity to parameters for malaria elimination","volume":"110","author":"OJ Brady","year":"2016","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pcbi.1010161.ref065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/inthealth\/ihv010","article-title":"Adult vector control, mosquito ecology and malaria transmission","volume":"7","author":"OJ Brady","year":"2015","journal-title":"Int Health"},{"key":"pcbi.1010161.ref066","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1046\/j.1365-3156.1998.00309.x","article-title":"Predicting key malaria transmission factors, biting and entomological inoculation rates, using modelled soil moisture in Kenya.","volume":"3","author":"JA Patz","year":"1998","journal-title":"Trop Med Int Health"},{"key":"pcbi.1010161.ref067","article-title":"Exploring the Influence of Daily Climate Variables on Malaria Transmission and Abundance of Anopheles arabiensis over Nkomazi Local Municipality, Mpumalanga Province, South Africa [Internet].","author":"GJ Abiodun","year":"2018","journal-title":"J. Environ."},{"key":"pcbi.1010161.ref068","first-page":"14","article-title":"Predicting malaria cases using remotely sensed environmental variables in Nkomazi, South Africa.","author":"AM Adeola","year":"2019","journal-title":"Geospatial Health"},{"key":"pcbi.1010161.ref069","article-title":"Remote Sensing-Driven Climatic\/Environmental Variables for Modelling Malaria Transmission in Sub-Saharan Africa.","author":"O Ebhuoma","year":"2016","journal-title":"Int J Environ Res Public Health [Internet]."},{"key":"pcbi.1010161.ref070","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4269\/ajtmh.2005.73.214","article-title":"Use of rainfall and sea surface temperature monitoring for malaria early warning in Botswana","volume":"73","author":"MC Thomson","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"pcbi.1010161.ref071","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1756-3305-4-153","article-title":"Modelling the impact of vector control interventions on Anopheles gambiae population dynamics","volume":"4","author":"MT White","year":"2011","journal-title":"Parasit Vectors"},{"key":"pcbi.1010161.ref072","first-page":"2","article-title":"Local scale prediction of Plasmodium falciparum malaria transmission in an endemic region using temperature and rainfall","author":"Y Y\u00e9","year":"2009","journal-title":"Glob Health Action."},{"key":"pcbi.1010161.ref073","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1038\/ncomms4136","article-title":"Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa","volume":"5","author":"JT Griffin","year":"2014","journal-title":"Nat Commun."},{"key":"pcbi.1010161.ref074","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12936-015-1048-x","article-title":"Treatment-seeking rates in malaria endemic countries","volume":"15","author":"KE Battle","year":"2016","journal-title":"Malar 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Kamya","year":"2007","journal-title":"PLoS Clin Trials"},{"key":"pcbi.1010161.ref081","doi-asserted-by":"crossref","first-page":"e2390","DOI":"10.1371\/journal.pone.0002390","article-title":"Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.","volume":"3","author":"A Yeka","year":"2008","journal-title":"PloS One"},{"key":"pcbi.1010161.ref082","doi-asserted-by":"crossref","first-page":"e7164","DOI":"10.1371\/journal.pone.0007164","article-title":"Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children.","volume":"4","author":"B Cisse","year":"2009","journal-title":"PloS One"},{"key":"pcbi.1010161.ref083","doi-asserted-by":"crossref","first-page":"736","DOI":"10.4269\/ajtmh.12-0654","article-title":"The Effects of ACT Treatment and TS Prophylaxis on Plasmodium falciparum Gametocytemia in a Cohort of Young 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Hyg"},{"key":"pcbi.1010161.ref087","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1086\/513990","article-title":"Clinical Manifestations of Plasmodium falciparum Malaria Experimentally Induced by Mosquito Challenge","volume":"175","author":"LWP Church","year":"1997","journal-title":"J Infect Dis"},{"key":"pcbi.1010161.ref088","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.trstmh.2005.11.001","article-title":"Distribution of survival times of deliberate Plasmodium falciparum infections in tertiary syphilis patients","volume":"100","author":"W Sama","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pcbi.1010161.ref089","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.epidem.2011.03.002","article-title":"The distribution of Plasmodium falciparum infection durations","volume":"3","author":"MT Bretscher","year":"2011","journal-title":"Epidemics"},{"key":"pcbi.1010161.ref090","doi-asserted-by":"crossref","first-page":"625","DOI":"10.4269\/ajtmh.2004.70.625","article-title":"Estimating the duration of Plasmodium falciparum infection from trials of indoor residual spraying","volume":"70","author":"W Sama","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"pcbi.1010161.ref091","article-title":"Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Na\u00efve and Vaccinated Hosts.","author":"TS Churcher","year":"2017","journal-title":"PLoS Pathog [Internet]"},{"key":"pcbi.1010161.ref092","doi-asserted-by":"crossref","first-page":"700","DOI":"10.4269\/ajtmh.1993.48.700","article-title":"High human malarial infectivity to laboratory-bred Anopheles gambiae in a village in Burkina Faso","volume":"48","author":"C Boudin","year":"1993","journal-title":"Am J Trop Med 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Tanzania","volume":"114","author":"JC Hogg","year":"1997","journal-title":"Parasitology"},{"key":"pcbi.1010161.ref096","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-2915.1993.tb00700.x","article-title":"Effects of adult body size on fecundity and the pre-gravid rate of Anopheles gambiae females in Tanzania","volume":"7","author":"EO Lyimo","year":"1993","journal-title":"Med Vet Entomol"},{"key":"pcbi.1010161.ref097","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1476-072X-13-17","article-title":"Modeling larval malaria vector habitat locations using landscape features and cumulative precipitation measures","volume":"13","author":"RS McCann","year":"2014","journal-title":"Int J Health Geogr"},{"key":"pcbi.1010161.ref098","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1098\/rspb.1998.0369","article-title":"Mapping the ranges and relative abundance of the two principal African malaria vectors, Anopheles gambiae sensu stricto and An. arabiensis, using climate data","volume":"265","author":"SW Lindsay","year":"1998","journal-title":"Proc R Soc B Biol Sci"},{"key":"pcbi.1010161.ref099","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4269\/ajtmh.2004.71.80","article-title":"Relationships between the outcome of Plasmodium falciparum infection and the intensity of transmission in Africa","volume":"71","author":"T Smith","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"pcbi.1010161.ref100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ncomms1107","article-title":"A quantitative analysis of transmission efficiency versus intensity for malaria","volume":"1","author":"DL Smith","year":"2010","journal-title":"Nat Commun."},{"key":"pcbi.1010161.ref101","volume-title":"The Epidemiology and Control of Malaria","author":"G. Macdonald","year":"1957"},{"key":"pcbi.1010161.ref102","doi-asserted-by":"crossref","first-page":"e1002588","DOI":"10.1371\/journal.ppat.1002588","article-title":"Ross, Macdonald, and a Theory for the Dynamics and Control of Mosquito-Transmitted Pathogens","volume":"8","author":"DL Smith","year":"2012","journal-title":"PLOS Pathog."},{"key":"pcbi.1010161.ref103","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1475-2875-7-12","article-title":"Estimation of heterogeneity in malaria transmission by stochastic modelling of apparent deviations from mass action kinetics","volume":"7","author":"TA Smith","year":"2008","journal-title":"Malar J."},{"key":"pcbi.1010161.ref104","article-title":"Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Na\u00efve and Vaccinated Hosts.","author":"TS Churcher","year":"2017","journal-title":"PLoS Pathog [Internet]"},{"key":"pcbi.1010161.ref105","first-page":"243","article-title":"Development and survival of Anopheles gambiae eggs in drying soil: influence of the rate of drying, egg age, and soil type","volume":"20","author":"JI Shililu","year":"2004","journal-title":"J Am Mosq Control Assoc"},{"key":"pcbi.1010161.ref106","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1475-2875-2-20","article-title":"Egg hatching, larval movement and larval survival of the malaria vector Anopheles gambiae in desiccating habitats","volume":"2","author":"CJ Koenraadt","year":"2003","journal-title":"Malar J"},{"key":"pcbi.1010161.ref107","first-page":"105","article-title":"Anopheles gambiae complex egg-stage survival in dry soil from larval development sites in western Kenya","volume":"6","author":"JC Beier","year":"1990","journal-title":"J Am Mosq Control Assoc"},{"key":"pcbi.1010161.ref108","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1475-2875-6-5","article-title":"Malaria vectors and transmission dynamics in coastal south-western Cameroon.","volume":"6","author":"JD Bigoga","year":"2007","journal-title":"Malar J"},{"key":"pcbi.1010161.ref109","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1756-3305-6-340","article-title":"Biting patterns and seasonality of Anopheles gambiae sensu lato and Anopheles funestus mosquitoes in Kamuli District, Uganda.","volume":"6","author":"FG Kabbale","year":"2013","journal-title":"Parasit Vectors"},{"key":"pcbi.1010161.ref110","author":"MN Bayoh","year":"2001"},{"key":"pcbi.1010161.ref111","volume-title":"Genetic Control of Malaria and Dengue. 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Lehane","year":"2005"},{"key":"pcbi.1010161.ref115","first-page":"129","article-title":"The duration of the gonotrophic cycle in Anopheles gambiae and Anopheles funestus, with a note on the efficiency of hand catching","volume":"30","author":"MT Gillies","year":"1953","journal-title":"East Afr Med J"},{"key":"pcbi.1010161.ref116","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1289\/ehp.0901256","article-title":"Modeling the Effects of Weather and Climate Change on Malaria Transmission","volume":"118","author":"PE Parham","year":"2010","journal-title":"Environ Health Perspect"},{"key":"pcbi.1010161.ref117","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1756-3305-6-20","article-title":"How malaria models relate temperature to malaria transmission","volume":"6","author":"TM Lunde","year":"2013","journal-title":"Parasit 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J."},{"key":"pcbi.1010161.ref121","doi-asserted-by":"crossref","first-page":"e106359","DOI":"10.1371\/journal.pone.0106359","article-title":"Time Series Analysis of Trends in Malaria Cases and Deaths at Hospitals and the Effect of Antimalarial Interventions, 2001\u20132011, Ethiopia","volume":"9","author":"M Aregawi","year":"2014","journal-title":"PLOS ONE"},{"key":"pcbi.1010161.ref122","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00484-001-0119-6","article-title":"The El Ni\u00f1o southern oscillation and malaria epidemics in South America","volume":"46","author":"AS Gagnon","year":"2002","journal-title":"Int J Biometeorol"},{"key":"pcbi.1010161.ref123","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/1475-2875-9-196","article-title":"Relevant microclimate for determining the development rate of malaria mosquitoes and possible implications of climate change","volume":"9","author":"KP Paaijmans","year":"2010","journal-title":"Malar 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gambiae and Anopheles atroparvus","author":"L Fernandes","year":"2005","journal-title":"J Vector Ecol J Soc Vector Ecol."},{"key":"pcbi.1010161.ref128","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1475-2875-7-141","article-title":"A physiological time analysis of the duration of the gonotrophic cycle of Anopheles pseudopunctipennis and its implications for malaria transmission in Bolivia.","volume":"7","author":"FJ Lardeux","year":"2008","journal-title":"Malar J"},{"key":"pcbi.1010161.ref129","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4269\/ajtmh.2010.09-0296","article-title":"Frequency of multiple blood meals taken in a single gonotrophic cycle by Anopheles arabiensis mosquitoes in Macha, Zambia","volume":"83","author":"LC Norris","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"pcbi.1010161.ref130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2307\/3279102","article-title":"Development of infectivity by the Plasmodium berghei sporozoite","volume":"61","author":"JP Vanderberg","year":"1975","journal-title":"J Parasitol"},{"key":"pcbi.1010161.ref131","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1462-5822.2006.00778.x","article-title":"Getting infectious: formation and maturation of Plasmodium sporozoites in the Anopheles vector","volume":"8","author":"K. Matuschewski","year":"2006","journal-title":"Cell Microbiol"},{"key":"pcbi.1010161.ref132","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1128\/IAI.00758-13","article-title":"Plasmodium berghei sporozoites acquire virulence and immunogenicity during mosquito hemocoel transit","volume":"82","author":"Y Sato","year":"2014","journal-title":"Infect Immun"},{"key":"pcbi.1010161.ref133","article-title":"Exploring the lower thermal limits for development of the human malaria parasite, Plasmodium falciparum","author":"JL Waite","year":"2019","journal-title":"Biol Lett [Internet]."},{"issue":"Pt 5","key":"pcbi.1010161.ref134","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1017\/S0031182000077003","article-title":"The impact of variations in temperature on early Plasmodium falciparum development in Anopheles stephensi","volume":"111","author":"BH Noden","year":"1995","journal-title":"Parasitology"},{"key":"pcbi.1010161.ref135","doi-asserted-by":"crossref","first-page":"13844","DOI":"10.1073\/pnas.0903423106","article-title":"Understanding the link between malaria risk and climate","volume":"106","author":"KP Paaijmans","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"pcbi.1010161.ref136","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/ee\/28.1.22","article-title":"A Novel Rate Model of Temperature-Dependent Development for Arthropods.","volume":"28","author":"J-F Briere","year":"1999","journal-title":"Environ Entomol."},{"key":"pcbi.1010161.ref137","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1086\/652456","article-title":"Identification of hot spots of malaria transmission for targeted malaria control","volume":"201","author":"T Bousema","year":"2010","journal-title":"J Infect Dis"},{"key":"pcbi.1010161.ref138","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1086\/524066","article-title":"Spatial variation of malaria incidence in young children from a geographically homogeneous area with high endemicity","volume":"197","author":"B Kreuels","year":"2008","journal-title":"J Infect Dis"},{"key":"pcbi.1010161.ref139","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.reprotox.2009.05.002","article-title":"Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester","volume":"28","author":"RL Clark","year":"2009","journal-title":"Reprod Toxicol Elmsford N"},{"key":"pcbi.1010161.ref140","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1086\/589778","article-title":"Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda","volume":"198","author":"TD Clark","year":"2008","journal-title":"J Infect Dis"},{"key":"pcbi.1010161.ref141","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1073\/pnas.94.1.338","article-title":"Heterogeneities in the transmission of infectious agents: implications for the design of control programs","volume":"94","author":"ME Woolhouse","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1010161.ref142","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1371\/journal.pbio.0050042","article-title":"Revisiting the Basic Reproductive Number for Malaria and Its Implications for Malaria Control.","volume":"5","author":"DL Smith","year":"2007","journal-title":"PLOS Biol."},{"key":"pcbi.1010161.ref143","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature04024","article-title":"The entomological inoculation rate and Plasmodium falciparum infection in African children","volume":"438","author":"DL Smith","year":"2005","journal-title":"Nature"},{"key":"pcbi.1010161.ref144","first-page":"124","article-title":"Does the global warming modify the local Rwandan climate?","volume":"5","author":"SM Henninger","year":"2013","journal-title":"Nat Sci."},{"key":"pcbi.1010161.ref145","article-title":"World malaria report 2018 country profiles [Internet].","author":"World Health Organization","year":"2018"},{"key":"pcbi.1010161.ref146","article-title":"World malaria report 2017 country profiles [Internet].","author":"World Health Organization","year":"2017"},{"key":"pcbi.1010161.ref147","article-title":"World malaria report 2016 country profiles [Internet].","author":"World Health Organization","year":"2016"},{"key":"pcbi.1010161.ref148","author":"MT Gillies","year":"1968"},{"key":"pcbi.1010161.ref149","first-page":"277","article-title":"The clay feet of the malaria giant and its African roots: hypotheses and inferences about origin, spread and control of Plasmodium falciparum","volume":"41","author":"M. Coluzzi","year":"1999","journal-title":"Parassitologia"},{"key":"pcbi.1010161.ref150","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12936-020-03579-w","article-title":"Monitoring mosquito nuisance for the development of a citizen science approach for malaria vector surveillance in Rwanda.","volume":"20","author":"MM Murindahabi","year":"2021","journal-title":"Malar J"},{"key":"pcbi.1010161.ref151","article-title":"Characterization of malaria vectors in Huye District, Southern Rwanda.","author":"C Nyirakanani","year":"2017","journal-title":"Tanzan J Health Res [Internet]"},{"key":"pcbi.1010161.ref152","article-title":"Health Surveillance & Emergency Preparedness & Response. [Internet].","author":"Ministry of Health (MoH).","year":"2016","journal-title":"Rwanda Biomed. Cent"},{"key":"pcbi.1010161.ref153","article-title":"Climate Hazards Center Datasets [Internet].","author":"University of California, Santa Barbara","year":"2020","journal-title":"Clim. Hazards Cent. UC St. Barbara"},{"key":"pcbi.1010161.ref154","article-title":"Assessment of the CHIRPS-Based Satellite Precipitation Estimates. Inland Waters\u2014Dyn Ecol [Internet].","author":"F Paredes-Trejo","year":"2020","journal-title":"IntechOpen"},{"key":"pcbi.1010161.ref155","first-page":"5639","article-title":"A High-Resolution 1983\u20132016 Tmax Climate Data Record Based on Infrared Temperatures and Stations by the Climate Hazard Center.","volume":"32","author":"C Funk","year":"2019","journal-title":"J Clim. 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