{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:27:35Z","timestamp":1773268055015,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010166","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000}}],"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["777072"],"award-info":[{"award-number":["777072"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["777072"],"award-info":[{"award-number":["777072"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To better understand the spatial correlation between the hypoxic regions and the occlusion sites, we used both\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments and\n                    <jats:italic>in silico<\/jats:italic>\n                    simulations to investigate the effects of occlusions in cerebral penetrating arteriole trees on tissue hypoxia. In a rat model of microembolisation, 25 \u03bcm microspheres were injected through the carotid artery to occlude penetrating arterioles. In representative models of human cortical columns, the penetrating arterioles were occluded by simulating the transport of microspheres of the same size and the oxygen transport was simulated using a Green\u2019s function method. The locations of microspheres and hypoxic regions were segmented, and two novel distance analyses were implemented to study their spatial correlation. The distant hypoxic regions were found to be present in both experiments and simulations, and mainly due to the hypoperfusion in the region downstream of the occlusion site. Furthermore, a reasonable agreement for the spatial correlation between hypoxic regions and occlusion sites is shown between experiments and simulations, which indicates the good applicability of\n                    <jats:italic>in silico<\/jats:italic>\n                    models in understanding the response of cerebral blood flow and oxygen transport to microemboli.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1010166","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T13:43:48Z","timestamp":1659707028000},"page":"e1010166","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-8671","authenticated-orcid":true,"given":"Yidan","family":"Xue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-8013","authenticated-orcid":true,"given":"Theodosia","family":"Georgakopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-5323","authenticated-orcid":true,"given":"Anne-Eva","family":"van der Wijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-0299","authenticated-orcid":true,"given":"Tam\u00e1s I.","family":"J\u00f3zsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-986X","authenticated-orcid":true,"given":"Ed","family":"van Bavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-2810","authenticated-orcid":true,"given":"Stephen J.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"pcbi.1010166.ref001","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/jnc.14234","article-title":"Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness","volume":"144","author":"T Tarumi","year":"2018","journal-title":"Journal of Neurochemistry"},{"key":"pcbi.1010166.ref002","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00022.2020","article-title":"Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation","volume":"101","author":"Thijssen DHJ Claassen JAHR","year":"2021","journal-title":"Physiological Reviews"},{"key":"pcbi.1010166.ref003","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1088\/0031-9155\/48\/15\/311","article-title":"Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy?","volume":"48","author":"DA Boas","year":"2003","journal-title":"Physics in Medicine and Biology"},{"key":"pcbi.1010166.ref004","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0361-9230(81)90007-1","article-title":"Cortical blood vessels of the human brain","volume":"7","author":"HM Duvernoy","year":"1981","journal-title":"Brain Research Bulletin"},{"key":"pcbi.1010166.ref005","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.joa.2017.03.007","article-title":"Reflex syncope: Diagnosis and treatment","volume":"33","author":"R. 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