{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:49:02Z","timestamp":1778510942097,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010226","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000}}],"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS110059"],"award-info":[{"award-number":["R01NS110059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>GABA is generally known as the principal inhibitory neurotransmitter in the nervous system, usually acting by hyperpolarizing membrane potential. However, GABAergic currents sometimes exhibit non-inhibitory effects, depending on the brain region, developmental stage or pathological condition. Here, we investigate the diverse effects of GABA on the firing rate of several single neuron models, using both analytical calculations and numerical simulations. We find that GABAergic synaptic conductance and output firing rate exhibit three qualitatively different regimes as a function of GABA reversal potential,<jats:italic>E<\/jats:italic><jats:sub>GABA<\/jats:sub>: monotonically decreasing for sufficiently low<jats:italic>E<\/jats:italic><jats:sub>GABA<\/jats:sub>(inhibitory), monotonically increasing for<jats:italic>E<\/jats:italic><jats:sub>GABA<\/jats:sub>above firing threshold (excitatory); and a non-monotonic region for intermediate values of<jats:italic>E<\/jats:italic><jats:sub>GABA<\/jats:sub>. In the non-monotonic regime, small GABA conductances have an excitatory effect while large GABA conductances show an inhibitory effect. We provide a phase diagram of different GABAergic effects as a function of GABA reversal potential and glutamate conductance. We find that noisy inputs increase the range of<jats:italic>E<\/jats:italic><jats:sub>GABA<\/jats:sub>for which the non-monotonic effect can be observed. We also construct a micro-circuit model of striatum to explain observed effects of GABAergic fast spiking interneurons on spiny projection neurons, including non-monotonicity, as well as the heterogeneity of the effects. Our work provides a mechanistic explanation of paradoxical effects of GABAergic synaptic inputs, with implications for understanding the effects of GABA in neural computation and development.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010226","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T17:34:05Z","timestamp":1654536845000},"page":"e1010226","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non-monotonic effects of GABAergic synaptic inputs on neuronal firing"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-7094","authenticated-orcid":true,"given":"Aghil","family":"Abed Zadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon 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Review"},{"issue":"3","key":"pcbi.1010226.ref034","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1088\/0954-898X_2_3_003","article-title":"Quantitative study of attractor neural network retrieving at low spike rates: I. Substrate\u2014spikes, rates and neuronal gain","volume":"2","author":"DJ Amit","year":"1991","journal-title":"Network: Computation in neural systems"},{"issue":"4","key":"pcbi.1010226.ref035","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1162\/0899766053429444","article-title":"Synaptic shot noise and conductance fluctuations affect the membrane voltage with equal significance","volume":"17","author":"MJ Richardson","year":"2005","journal-title":"Neural computation"},{"key":"pcbi.1010226.ref036","doi-asserted-by":"crossref","unstructured":"Sanzeni A, Histed MH, Brunel N. Emergence of irregular activity in networks of strongly coupled conductance-based neurons. arXiv preprint arXiv:200912023. 2020;.","DOI":"10.1101\/2020.09.24.312579"},{"key":"pcbi.1010226.ref037","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-87708-2","volume-title":"Mathematical foundations of neuroscience","author":"GB Ermentrout","year":"2010"},{"issue":"43","key":"pcbi.1010226.ref038","doi-asserted-by":"crossref","first-page":"10814","DOI":"10.1523\/JNEUROSCI.2660-08.2008","article-title":"Dichotomous anatomical properties of adult striatal medium spiny neurons","volume":"28","author":"TS Gertler","year":"2008","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"pcbi.1010226.ref039","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1113\/jphysiol.1991.sp018850","article-title":"Membrane properties and synaptic responses of rat striatal neurones in vitro","volume":"443","author":"Z Jiang","year":"1991","journal-title":"The Journal of 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Tapia","year":"2019","journal-title":"NeuroReport"},{"issue":"7","key":"pcbi.1010226.ref043","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/s41593-019-0422-3","article-title":"Thermal constraints on in vivo optogenetic manipulations","volume":"22","author":"SF Owen","year":"2019","journal-title":"Nature neuroscience"},{"issue":"4","key":"pcbi.1010226.ref044","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/jtbi.1999.1002","article-title":"Simplified dynamics of human and mammalian neocortical neurons","volume":"200","author":"HR Wilson","year":"1999","journal-title":"Journal of theoretical biology"},{"issue":"6","key":"pcbi.1010226.ref045","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1152\/jn.00988.2004","article-title":"Possible effects of depolarizing GABAA conductance on the neuronal input\u2013output relationship: a modeling study","volume":"93","author":"K Morita","year":"2005","journal-title":"Journal of 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Prescott","year":"2006","journal-title":"Molecular pain"},{"issue":"46","key":"pcbi.1010226.ref058","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1523\/JNEUROSCI.4228-15.2016","article-title":"Reduced efficacy of the KCC2 cotransporter promotes epileptic oscillations in a subiculum network model","volume":"36","author":"A Buchin","year":"2016","journal-title":"Journal of Neuroscience"},{"key":"pcbi.1010226.ref059","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.expneurol.2016.05.037","article-title":"Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome","volume":"283","author":"P Kurbatova","year":"2016","journal-title":"Experimental neurology"},{"issue":"3","key":"pcbi.1010226.ref060","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0896-6273(03)00200-9","article-title":"Shunting inhibition modulates neuronal gain during synaptic excitation","volume":"38","author":"SJ 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and coherence of gamma oscillation in network simulations","volume":"23","author":"A Proddutur","year":"2013","journal-title":"Chaos: An Interdisciplinary Journal of Nonlinear Science"},{"issue":"1","key":"pcbi.1010226.ref064","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10827-005-0188-3","article-title":"Phase dependent sign changes of GABAergic synaptic input explored in-silicio and in-vitro","volume":"19","author":"KM Stiefel","year":"2005","journal-title":"Journal of computational neuroscience"},{"issue":"5597","key":"pcbi.1010226.ref065","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1126\/science.1076510","article-title":"On the origin of interictal activity in human temporal lobe epilepsy in vitro","volume":"298","author":"I Cohen","year":"2002","journal-title":"Science"},{"issue":"244","key":"pcbi.1010226.ref066","doi-asserted-by":"crossref","first-page":"244ra89","DOI":"10.1126\/scitranslmed.3008065","article-title":"Cortical GABAergic excitation 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