{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:07:04Z","timestamp":1774735624206,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010255","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000}}],"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PCI2020-112026"],"award-info":[{"award-number":["PCI2020-112026"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA053014"],"award-info":[{"award-number":["R01DA053014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA053014"],"award-info":[{"award-number":["R01DA053014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>In situations featuring uncertainty about action-reward contingencies, mammals can flexibly adopt strategies for decision-making that are tuned in response to environmental changes. Although the cortico-basal ganglia thalamic (CBGT) network has been identified as contributing to the decision-making process, it features a complex synaptic architecture, comprised of multiple feed-forward, reciprocal, and feedback pathways, that complicate efforts to elucidate the roles of specific CBGT populations in the process by which evidence is accumulated and influences behavior. In this paper we apply a strategic sampling approach, based on Latin hypercube sampling, to explore how variations in CBGT network properties, including subpopulation firing rates and synaptic weights, map to variability of parameters in a normative drift diffusion model (DDM), representing algorithmic aspects of information processing during decision-making. Through the application of canonical correlation analysis, we find that this relationship can be characterized in terms of three low-dimensional control ensembles within the CBGT network that impact specific qualities of the emergent decision policy: responsiveness (a measure of how quickly evidence evaluation gets underway, associated with overall activity in corticothalamic and direct pathways), pliancy (a measure of the standard of evidence needed to commit to a decision, associated largely with overall activity in components of the indirect pathway of the basal ganglia), and choice (a measure of commitment toward one available option, associated with differences in direct and indirect pathways across action channels). These analyses provide mechanistic predictions about the roles of specific CBGT network elements in tuning the way that information is accumulated and translated into decision-related behavior.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010255","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T13:50:11Z","timestamp":1655992211000},"page":"e1010255","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Identifying control ensembles for information processing within the cortico-basal ganglia-thalamic circuit"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-9371","authenticated-orcid":true,"given":"Catalina","family":"Vich","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-195X","authenticated-orcid":true,"given":"Matthew","family":"Clapp","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-1551","authenticated-orcid":true,"given":"Jonathan E.","family":"Rubin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-0336","authenticated-orcid":true,"given":"Timothy","family":"Verstynen","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"issue":"30","key":"pcbi.1010255.ref001","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.neuro.29.051605.113038","article-title":"The neural basis of decision making","volume":"30","author":"JI Gold","year":"2007","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"pcbi.1010255.ref002","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1037\/0033-295X.85.2.59","article-title":"A theory of Memory Retrival","volume":"85","author":"R Ratcliff","year":"1978","journal-title":"Psychol Rev"},{"key":"pcbi.1010255.ref003","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.conb.2018.11.003","article-title":"The algorithmic architecture of exploration in the human brain","volume":"55","author":"E Schulz","year":"2019","journal-title":"Current opinion in neurobiology"},{"issue":"10","key":"pcbi.1010255.ref004","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","article-title":"The functional anatomy of basal ganglia disorders","volume":"12","author":"RL Albin","year":"1989","journal-title":"Trends in Neurosciences"},{"issue":"4","key":"pcbi.1010255.ref005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0301-0082(96)00042-1","article-title":"The basal ganglia: focused selection and inhibition of competing motor programs","volume":"50","author":"JW Mink","year":"1996","journal-title":"Progress in neurobiology"},{"issue":"7","key":"pcbi.1010255.ref006","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0166-2236(90)90107-L","article-title":"Functional architecture of basal ganglia circuits: neural substrates of parallel processing","volume":"13","author":"GE Alexander","year":"1990","journal-title":"Trends Neurosci"},{"issue":"6","key":"pcbi.1010255.ref007","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/PL00007984","article-title":"A computational model of action selection in the basal ganglia. 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