{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:19:06Z","timestamp":1785377946488,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010391","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000}}],"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12105117"],"award-info":[{"award-number":["12105117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21621007"],"award-info":[{"award-number":["21621007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010523"],"award-info":[{"award-number":["2022A1515010523"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>The COVID-19 pandemic demonstrated that the process of global vaccination against a novel virus can be a prolonged one. Social distancing measures, that are initially adopted to control the pandemic, are gradually relaxed as vaccination progresses and population immunity increases. The result is a prolonged period of high disease prevalence combined with a fitness advantage for vaccine-resistant variants, which together lead to a considerably increased probability for vaccine escape. A spatial vaccination strategy is proposed that has the potential to dramatically reduce this risk. Rather than dispersing the vaccination effort evenly throughout a country, distinct geographic regions of the country are sequentially vaccinated, quickly bringing each to effective herd immunity. Regions with high vaccination rates will then have low infection rates and vice versa. Since people primarily interact within their own region, spatial vaccination reduces the number of encounters between infected individuals (the source of mutations) and vaccinated individuals (who facilitate the spread of vaccine-resistant strains). Thus, spatial vaccination may help mitigate the global risk of vaccine-resistant variants.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010391","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T17:39:13Z","timestamp":1660153153000},"page":"e1010391","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A spatial vaccination strategy to reduce the risk of vaccine-resistant variants"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9251-7466","authenticated-orcid":true,"given":"Xiyun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Lobinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Dekel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitzhak","family":"Pilpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan","family":"Pauzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baruch","family":"Barzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-6686","authenticated-orcid":true,"given":"Ady","family":"Pauzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"pcbi.1010391.ref001","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jtbi.2013.01.006","article-title":"The importance of contact network topology for the success of vaccination strategies","volume":"325","author":"J Ma","year":"2013","journal-title":"Journal of Theoretical Biology"},{"key":"pcbi.1010391.ref002","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0272989X14523502","article-title":"A Marginal Benefit Approach for Vaccinating Influenza \u201cSuperspreaders\u201d.","volume":"34","author":"KJ Skene","year":"2014","journal-title":"Medical Decision Making"},{"issue":"8","key":"pcbi.1010391.ref003","doi-asserted-by":"crossref","first-page":"e1009351","DOI":"10.1371\/journal.pcbi.1009351","article-title":"Targeted pandemic containment through identifying local contact network bottlenecks","volume":"17","author":"S Yang","year":"2021","journal-title":"PloS Computational Biology"},{"key":"pcbi.1010391.ref004","doi-asserted-by":"crossref","first-page":"eabg3055","DOI":"10.1126\/science.abg3055","article-title":"Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England.","volume":"372","author":"NG Davies","year":"2021","journal-title":"Science"},{"key":"pcbi.1010391.ref005","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41591-021-01255-3","article-title":"Sixteen novel lineages of SARS-CoV-2 in South Africa.","volume":"27","author":"H Tegally","year":"2021","journal-title":"Nat. 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Luong","year":"2019"},{"key":"pcbi.1010391.ref026","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/1469-0691.12308","article-title":"Mathematical modelling and prediction in infectious disease epidemiology","volume":"19","author":"A Huppert","year":"2013","journal-title":"Clinical Microbiology and Infection"},{"key":"pcbi.1010391.ref027","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/eva.12196","article-title":"The fitness costs of antibiotic resistance mutations.","volume":"8","author":"AH Melnyk","year":"2015","journal-title":"Evol Appl"},{"key":"pcbi.1010391.ref028","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.cell.2021.02.042","article-title":"SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape","volume":"184","author":"Q Li","year":"2021","journal-title":"Cell"},{"key":"pcbi.1010391.ref029","volume-title":"American Community Survey Reports","author":"B Charlynn","year":"2021"},{"key":"pcbi.1010391.ref030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1126\/sciimmunol.aba6466","article-title":"A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain.","volume":"5","author":"KA Swanson","year":"2020","journal-title":"Science Immunology"},{"key":"pcbi.1010391.ref031","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chom.2021.02.003","article-title":"Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.","volume":"29","author":"AJ Greaney","year":"2021","journal-title":"Cell Host & Microbe"},{"key":"pcbi.1010391.ref032","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41564-021-01053-0","article-title":"Effectiveness of COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario.","volume":"7","author":"S Nasreen","year":"2022","journal-title":"Nature Microbiology"},{"key":"pcbi.1010391.ref033","unstructured":"Public Health England, https:\/\/www.gov.uk\/government\/news\/vaccines-highly-effective-against-b-1-617-2-variant-after-2-doses"},{"issue":"1533","key":"pcbi.1010391.ref034","first-page":"2573","article-title":"Evolutionary dynamics of escape from biomedical intervention, Proceedings of the Royal Society of London.","volume":"270","author":"Y Iwasa","year":"2003","journal-title":"Series B: Biological Sciences"},{"issue":"1636","key":"pcbi.1010391.ref035","first-page":"861","article-title":"Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus), Proceedings of the Royal Society B: Biological Sciences.","volume":"275","author":"RK 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