{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:02:18Z","timestamp":1768993338851,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010412","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000}}],"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016970","name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P20_00592"],"award-info":[{"award-number":["P20_00592"]}],"id":[{"id":"10.13039\/100016970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PGC2018-096540-B-I00"],"award-info":[{"award-number":["PGC2018-096540-B-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016970","name":"Consejer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["US-1254251"],"award-info":[{"award-number":["US-1254251"]}],"id":[{"id":"10.13039\/100016970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"crossref","award":["HUM-609"],"award-info":[{"award-number":["HUM-609"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NextGenerationEU","award":["MSALAS-2022-19827"],"award-info":[{"award-number":["MSALAS-2022-19827"]}]},{"DOI":"10.13039\/501100007064","name":"Universidad de Ja\u00e9n","doi-asserted-by":"crossref","award":["PAIUJA-EI_CTS02_2021"],"award-info":[{"award-number":["PAIUJA-EI_CTS02_2021"]}],"id":[{"id":"10.13039\/501100007064","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"crossref","award":["BIO-302"],"award-info":[{"award-number":["BIO-302"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008062","name":"Fundaci\u00f3n Alicia Koplowitz","doi-asserted-by":"publisher","award":["OTR08262-2021"],"award-info":[{"award-number":["OTR08262-2021"]}],"id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-105772GB-I00 \/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2019-105772GB-I00 \/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["896354"],"award-info":[{"award-number":["896354"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["170873"],"award-info":[{"award-number":["170873"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["T.0134.21"],"award-info":[{"award-number":["T.0134.21"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010664","name":"H2020 Future and Emerging Technologies","doi-asserted-by":"publisher","award":["945539"],"award-info":[{"award-number":["945539"]}],"id":[{"id":"10.13039\/100010664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["H2020-FETOPEN-2014-2015-RIA"],"award-info":[{"award-number":["H2020-FETOPEN-2014-2015-RIA"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["FP7-HEALTH-602150"],"award-info":[{"award-number":["FP7-HEALTH-602150"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["EU-2020-MSCA-RISE-778234"],"award-info":[{"award-number":["EU-2020-MSCA-RISE-778234"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471100"],"award-info":[{"award-number":["81471100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>The self-organising global dynamics underlying brain states emerge from complex recursive nonlinear interactions between interconnected brain regions. Until now, most efforts of capturing the causal mechanistic generating principles have supposed underlying stationarity, being unable to describe the non-stationarity of brain dynamics, i.e. time-dependent changes. Here, we present a novel framework able to characterise brain states with high specificity, precisely by modelling the time-dependent dynamics. Through describing a topological structure associated to the brain state at each moment in time (its attractor or \u2018information structure\u2019), we are able to classify different brain states by using the statistics across time of these structures hitherto hidden in the neuroimaging dynamics. Proving the strong potential of this framework, we were able to classify resting-state BOLD fMRI signals from two classes of post-comatose patients (minimally conscious state and unresponsive wakefulness syndrome) compared with healthy controls with very high precision.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1010412","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T17:47:18Z","timestamp":1662486438000},"page":"e1010412","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["What lies underneath: Precise classification of brain states using time-dependent topological structure of dynamics"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-4136","authenticated-orcid":true,"given":"Fernando","family":"Soler-Toscano","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-4241","authenticated-orcid":true,"given":"Javier A.","family":"Galad\u00ed","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-9737","authenticated-orcid":true,"given":"Anira","family":"Escrichs","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-5564","authenticated-orcid":true,"given":"Yonatan","family":"Sanz Perl","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-0424","authenticated-orcid":true,"given":"Ane","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[]},{"given":"Jacobo D.","family":"Sitt","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-4345","authenticated-orcid":true,"given":"Jitka","family":"Annen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9011-7496","authenticated-orcid":true,"given":"Olivia","family":"Gosseries","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-1747","authenticated-orcid":true,"given":"Aurore","family":"Thibaut","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-4340","authenticated-orcid":true,"given":"Rajanikant","family":"Panda","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-2973","authenticated-orcid":true,"given":"Francisco J.","family":"Esteban","sequence":"additional","affiliation":[]},{"given":"Steven","family":"Laureys","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-6898","authenticated-orcid":true,"given":"Morten L.","family":"Kringelbach","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-0764","authenticated-orcid":true,"given":"Jos\u00e9 A.","family":"Langa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-7583","authenticated-orcid":true,"given":"Gustavo","family":"Deco","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"issue":"5","key":"pcbi.1010412.ref001","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.neuron.2014.08.034","article-title":"Great Expectations: Using Whole-Brain Computational Connectomics for Understanding Neuropsychiatric Disorders","volume":"84","author":"G Deco","year":"2014","journal-title":"Neuron"},{"issue":"36","key":"pcbi.1010412.ref002","doi-asserted-by":"crossref","first-page":"18088","DOI":"10.1073\/pnas.1905534116","article-title":"Awakening: Predicting external stimulation to force transitions between different brain states","volume":"116","author":"G Deco","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"49","key":"pcbi.1010412.ref003","doi-asserted-by":"crossref","first-page":"11137","DOI":"10.1523\/JNEUROSCI.3524-04.2004","article-title":"Global Forebrain Dynamics Predict Rat Behavioral States and Their Transitions","volume":"24","author":"D Gervasoni","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"pcbi.1010412.ref004","volume-title":"Unlocking the Brain: Volume 1: Coding","author":"G Northoff","year":"2013"},{"issue":"11","key":"pcbi.1010412.ref005","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1073\/pnas.91.11.5033","article-title":"A measure for brain complexity: relating functional segregation and integration in the nervous system","volume":"91","author":"G Tononi","year":"1994","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"pcbi.1010412.ref006","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat7603","article-title":"Human consciousness is supported by dynamic complex patterns of brain signal coordination","volume":"5","author":"A Demertzi","year":"2019","journal-title":"Science Advances"},{"key":"pcbi.1010412.ref007","doi-asserted-by":"crossref","first-page":"118551","DOI":"10.1016\/j.neuroimage.2021.118551","article-title":"Capturing the non-stationarity of whole-brain dynamics underlying human brain states","volume":"244","author":"JA Galad\u00ed","year":"2021","journal-title":"NeuroImage"},{"issue":"3","key":"pcbi.1010412.ref008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1003530","article-title":"Relating Structure and Function in the Human Brain: Relative Contributions of Anatomy, Stationary Dynamics, and Non-stationarities","volume":"10","author":"A Mess\u00e9","year":"2014","journal-title":"PLOS Computational Biology"},{"key":"pcbi.1010412.ref009","volume-title":"Applied Mathematical Sciences","author":"A Carvalho","year":"2012"},{"issue":"3","key":"pcbi.1010412.ref010","first-page":"585","article-title":"The fundamental theorem of dynamical systems","volume":"36","author":"DE Norton","year":"1995","journal-title":"Commentationes Mathematicae Universitatis Carolinae"},{"issue":"9","key":"pcbi.1010412.ref011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1006154","article-title":"Informational structures: A dynamical system approach for integrated information","volume":"14","author":"FJ Esteban","year":"2018","journal-title":"PLOS Computational Biology"},{"issue":"1","key":"pcbi.1010412.ref012","first-page":"57","article-title":"Continuity of Lyapunov functions and of energy level for a generalized gradient semigroup","volume":"39","author":"E Aragao-Costa","year":"2012","journal-title":"Topol Methods Nonlinear Anal"},{"key":"pcbi.1010412.ref013","unstructured":"Galad\u00ed J. Dynamical systems applied to consciousness and brain rhythms in a neural network. Department of Differential Equations and Numerical Analysis. University of Seville; 2020. Available from: https:\/\/idus.us.es\/bitstream\/handle\/11441\/97528\/GALADI GARCIA, JAVIER ALE. Tesis.pdf?sequence=1."},{"issue":"3","key":"pcbi.1010412.ref014","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1212\/WNL.58.3.349","article-title":"The minimally conscious state: definition and diagnostic criteria","volume":"58","author":"JT Giacino","year":"2002","journal-title":"Neurology"},{"key":"pcbi.1010412.ref015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1741-7015-8-68","article-title":"Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome","volume":"8","author":"S Laureys","year":"2010","journal-title":"BMC Med"},{"issue":"3","key":"pcbi.1010412.ref016","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"BT Thomas Yeo","year":"2011","journal-title":"Journal of Neurophysiology"},{"key":"pcbi.1010412.ref017","article-title":"Global structural stability and the role of cooperation in mutualistic systems","author":"JR Portillo","year":"2022","journal-title":"PLOS ONE"},{"issue":"1","key":"pcbi.1010412.ref018","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-03576-6","article-title":"Unifying turbulent dynamics framework distinguishes different brain states","volume":"5","author":"A Escrichs","year":"2022","journal-title":"Communications Biology"},{"issue":"1","key":"pcbi.1010412.ref019","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-02537-9","article-title":"Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics","volume":"4","author":"A L\u00f3pez-Gonz\u00e1lez","year":"2021","journal-title":"Communications Biology"},{"issue":"1","key":"pcbi.1010412.ref020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ana.26095","article-title":"Preservation of Brain Activity in Unresponsive Patients Identifies MCS Star","volume":"90","author":"A Thibaut","year":"2021","journal-title":"Annals of Neurology"},{"key":"pcbi.1010412.ref021","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(14)60042-8","article-title":"Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study","volume":"384","author":"J Stender","year":"2014","journal-title":"Lancet (London, England)"},{"key":"pcbi.1010412.ref022","doi-asserted-by":"crossref","first-page":"116316","DOI":"10.1016\/j.neuroimage.2019.116316","article-title":"Pharmacologically informed machine learning approach for identifying pathological states of unconsciousness via resting-state fMRI","volume":"206","author":"JM Campbell","year":"2020","journal-title":"NeuroImage"},{"key":"pcbi.1010412.ref023","doi-asserted-by":"crossref","unstructured":"Thornton C, Hutter F, Hoos HH, Leyton-Brown K. Auto-WEKA: Combined Selection and Hyperparameter Optimization of Classification Algorithms. In: Proc. of KDD-2013; 2013. p. 847\u2013855.","DOI":"10.1145\/2487575.2487629"},{"key":"pcbi.1010412.ref024","volume-title":"Morgan Kaufmann Series in Data Management Systems","author":"IH Witten","year":"2011","edition":"3"},{"issue":"3","key":"pcbi.1010412.ref025","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1073\/pnas.1418031112","article-title":"Signature of consciousness in the dynamics of resting-state brain activity","volume":"112","author":"P Barttfeld","year":"2015","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pcbi.1010412.ref026","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neunet.2007.09.004","article-title":"Indirect biological measures of consciousness from field studies of brains as dynamical systems","volume":"20","author":"W Freeman","year":"2007","journal-title":"Neural networks"},{"key":"pcbi.1010412.ref027","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fphys.2012.00015","article-title":"Criticality in Large-Scale Brain fMRI Dynamics Unveiled by a Novel Point Process Analysis","volume":"3","author":"E Tagliazucchi","year":"2012","journal-title":"Frontiers in Physiology"},{"key":"pcbi.1010412.ref028","doi-asserted-by":"crossref","DOI":"10.1038\/srep38866","article-title":"Distinct Interactions between Fronto-Parietal and Default Mode Networks in Impaired Consciousness","volume":"6","author":"J Long","year":"2016","journal-title":"Scientific reports"},{"issue":"6","key":"pcbi.1010412.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0100012","article-title":"Posterior Cingulate Cortex-Related Co-Activation Patterns: A Resting State fMRI Study in Propofol-Induced Loss of Consciousness","volume":"9","author":"E Amico","year":"2014","journal-title":"PLOS ONE"},{"issue":"8","key":"pcbi.1010412.ref030","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S1474-4422(16)00111-3","article-title":"Neural correlates of consciousness in patients who have emerged from a minimally conscious state: a cross-sectional multimodal imaging study","volume":"15","author":"C Di Perri","year":"2016","journal-title":"Lancet Neurol"},{"issue":"11","key":"pcbi.1010412.ref031","doi-asserted-by":"crossref","first-page":"eaaz0087","DOI":"10.1126\/sciadv.aaz0087","article-title":"Temporal circuit of macroscale dynamic brain activity supports human consciousness","volume":"6","author":"Z Huang","year":"2020","journal-title":"Science Advances"},{"issue":"9","key":"pcbi.1010412.ref032","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/brain\/awv169","article-title":"Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients","volume":"138","author":"A Demertzi","year":"2015","journal-title":"Brain"},{"issue":"8","key":"pcbi.1010412.ref033","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4329\/wjr.v6.i8.589","article-title":"Measuring consciousness in coma and related states","volume":"6","author":"CD Perri","year":"2014","journal-title":"World Journal of Radiology"},{"key":"pcbi.1010412.ref034","doi-asserted-by":"crossref","unstructured":"Cohen WW. Fast Effective Rule Induction. In: Twelfth International Conference on Machine Learning. Morgan Kaufmann; 1995. p. 115\u2013123.","DOI":"10.1016\/B978-1-55860-377-6.50023-2"},{"key":"pcbi.1010412.ref035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0020-7373(87)80053-6","article-title":"Simplifying Decision Trees","volume":"27","author":"JR Quinlan","year":"1987","journal-title":"Int J Man Mach Stud"},{"key":"pcbi.1010412.ref036","doi-asserted-by":"crossref","DOI":"10.1002\/9781118548387","volume-title":"Applied Logistic Regression","author":"DW Hosmer","year":"2013"},{"issue":"5","key":"pcbi.1010412.ref037","doi-asserted-by":"crossref","DOI":"10.3390\/e21050493","article-title":"Informational Structures and Informational Fields as a Prototype for the Description of Postulates of the Integrated Information Theory","volume":"21","author":"P Kalita","year":"2019","journal-title":"Entropy"},{"key":"pcbi.1010412.ref038","first-page":"83","volume-title":"Top-Down Causation and Autonomy in Complex Systems","author":"A Juarrero","year":"2009"},{"key":"pcbi.1010412.ref039","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2016.04.024","article-title":"The Minimal Energetic Requirement of Sustained Awareness after Brain Injury","volume":"26","author":"J Stender","year":"2016","journal-title":"Current Biology"},{"issue":"5","key":"pcbi.1010412.ref040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1003588","article-title":"From the Phenomenology to the Mechanisms of Consciousness: Integrated Information Theory 3.0","volume":"10","author":"M Oizumi","year":"2014","journal-title":"PLOS Computational Biology"},{"issue":"1","key":"pcbi.1010412.ref041","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"issue":"198","key":"pcbi.1010412.ref042","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006294","article-title":"A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior","volume":"5","author":"AG Casali","year":"2013","journal-title":"Science Translational Medicine"},{"key":"pcbi.1010412.ref043","doi-asserted-by":"crossref","first-page":"105093","DOI":"10.1016\/j.cnsns.2019.105093","article-title":"Emergence and interpretation of oscillatory behaviour similar to brain waves and rhythms","volume":"83","author":"J Galad\u00ed","year":"2020","journal-title":"Communications in Nonlinear Science and Numerical Simulation"},{"issue":"1","key":"pcbi.1010412.ref044","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-83425-4","article-title":"Flexible brain dynamics underpins complex behaviours as observed in Parkinson\u2019s disease","volume":"11","author":"P Sorrentino","year":"2021","journal-title":"Scientific Reports"},{"issue":"1","key":"pcbi.1010412.ref045","article-title":"Measuring Integrated Information: Comparison of Candidate Measures in Theory and Simulation","volume":"21","author":"PAM Mediano","year":"2019","journal-title":"Entropy"},{"key":"pcbi.1010412.ref046","doi-asserted-by":"crossref","first-page":"112094","DOI":"10.1016\/j.chaos.2022.112094","article-title":"Model transform and local parameters. Application to instantaneous attractors","volume":"159","author":"JA Galad\u00ed","year":"2022","journal-title":"Chaos, Solitons & Fractals"},{"issue":"1","key":"pcbi.1010412.ref047","doi-asserted-by":"crossref","DOI":"10.3390\/e23010097","article-title":"An ESR Framework for the Study of Consciousness","volume":"23","author":"D Stanciu","year":"2021","journal-title":"Entropy"},{"issue":"1","key":"pcbi.1010412.ref048","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/B:SYNT.0000047712.39407.c3","article-title":"On the Preferability of Epistemic Structural Realism","volume":"142","author":"M Morganti","year":"2004","journal-title":"Synthese"},{"issue":"3","key":"pcbi.1010412.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1000314","article-title":"Broadband Criticality of Human Brain Network Synchronization","volume":"5","author":"MG Kitzbichler","year":"2009","journal-title":"PLOS Computational Biology"},{"issue":"1","key":"pcbi.1010412.ref050","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12658-9","article-title":"Consciousness-specific dynamic interactions of brain integration and functional diversity","volume":"10","author":"AI Luppi","year":"2019","journal-title":"Nature Communications"},{"key":"pcbi.1010412.ref051","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.neuroimage.2017.09.065","article-title":"Dynamic functional connectivity and brain metastability during altered states of consciousness","volume":"180","author":"F Cavanna","year":"2018","journal-title":"NeuroImage"},{"issue":"6","key":"pcbi.1010412.ref052","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1097\/ALN.0000000000003197","article-title":"Altered Global Brain Signal during Physiologic, Pharmacologic, and Pathologic States of Unconsciousness in Humans and Rats","volume":"132","author":"S Tanabe","year":"2020","journal-title":"Anesthesiology"},{"key":"pcbi.1010412.ref053","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2021.625919","article-title":"Dynamic Patterns of Global Brain Communication Differentiate Conscious From Unconscious Patients After Severe Brain Injury","volume":"15","author":"D Golkowski","year":"2021","journal-title":"Frontiers in Systems Neuroscience"},{"issue":"6","key":"pcbi.1010412.ref054","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/ALN.0000000000002704","article-title":"Changes in Whole Brain Dynamics and Connectivity Patterns during Sevoflurane- and Propofol-induced Unconsciousness Identified by Functional Magnetic Resonance Imaging","volume":"130","author":"D Golkowski","year":"2019","journal-title":"Anesthesiology"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1010412","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1010412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T18:04:07Z","timestamp":1663351447000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1010412"}},"subtitle":[],"editor":[{"given":"Dustin","family":"Scheinost","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1010412","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1010412","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]}}}