{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:15:22Z","timestamp":1791476122536,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010755","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000}}],"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI143698-01A1"],"award-info":[{"award-number":["1R01AI143698-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["HR0011-17-2-0047"],"award-info":[{"award-number":["HR0011-17-2-0047"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Close-kin mark-recapture (CKMR) methods have recently been used to infer demographic parameters such as census population size and survival for fish of interest to fisheries and conservation. These methods have advantages over traditional mark-recapture methods as the mark is genetic, removing the need for physical marking and recapturing that may interfere with parameter estimation. For mosquitoes, the spatial distribution of close-kin pairs has been used to estimate mean dispersal distance, of relevance to vector-borne disease transmission and novel biocontrol strategies. Here, we extend CKMR methods to the life history of mosquitoes and comparable insects. We derive kinship probabilities for mother-offspring, father-offspring, full-sibling and half-sibling pairs, where an individual in each pair may be a larva, pupa or adult. A pseudo-likelihood approach is used to combine the marginal probabilities of all kinship pairs. To test the effectiveness of this approach at estimating mosquito demographic parameters, we develop an individual-based model of mosquito life history incorporating egg, larva, pupa and adult life stages. The simulation labels each individual with a unique identification number, enabling close-kin relationships to be inferred for sampled individuals. Using the dengue vector\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    as a case study, we find the CKMR approach provides unbiased estimates of adult census population size, adult and larval mortality rates, and larval life stage duration for logistically feasible sampling schemes. Considering a simulated population of 3,000 adult mosquitoes, estimation of adult parameters is accurate when ca. 40 adult females are sampled biweekly over a three month period. Estimation of larval parameters is accurate when adult sampling is supplemented with ca. 120 larvae sampled biweekly over the same period. The methods are also effective at detecting intervention-induced increases in adult mortality and decreases in population size. As the cost of genome sequencing declines, CKMR holds great promise for characterizing the demography of mosquitoes and comparable insects of epidemiological and agricultural significance.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1010755","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T13:36:14Z","timestamp":1670852174000},"page":"e1010755","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Close-kin mark-recapture methods to estimate demographic parameters of mosquitoes"],"prefix":"10.1371","volume":"18","author":[{"given":"Yogita","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4718-257X","authenticated-orcid":true,"given":"Jared 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of southern bluefin tuna estimated by close-kin mark-recapture","volume":"7","author":"MV Bravington","year":"2016","journal-title":"Nature Communications"},{"key":"pcbi.1010755.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-20593-w","article-title":"Genetic relatedness reveals total population size of white sharks in eastern Australia and New Zealand","volume":"8","author":"RM Hillary","year":"2018","journal-title":"Scientific Reports"},{"key":"pcbi.1010755.ref004","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1111\/2041-210X.13243","article-title":"Validation of close-kin mark-recapture (CKMR) methods for estimating population abundance","volume":"10","author":"DE Ruzzante","year":"2019","journal-title":"Methods in Ecology and Evolution"},{"key":"pcbi.1010755.ref005","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1002\/ece3.7279","article-title":"Considering sampling bias in close-kin mark-recapture abundance estimates of Atlantic salmon","volume":"11","author":"S Wacker","year":"2021","journal-title":"Ecology and Evolution"},{"key":"pcbi.1010755.ref006","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/1755-0998.13043","article-title":"A genomic approach to inferring kinship reveals limited intergenerational dispersal in the yellow fever mosquito","volume":"19","author":"M Jasper","year":"2019","journal-title":"Molecular Ecology Resources"},{"key":"pcbi.1010755.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12915-020-00841-0","article-title":"Using spatial genetics to quantify mosquito dispersal for control programs","volume":"18","author":"I Filipovi\u0107","year":"2020","journal-title":"BMC Biology"},{"key":"pcbi.1010755.ref008","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1016\/j.cub.2019.11.007","article-title":"Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control","volume":"29","author":"WA Nazni","year":"2019","journal-title":"Current Biology"},{"key":"pcbi.1010755.ref009","article-title":"Wolbachia-mediated sterility suppresses Aedes aegypti populations in the urban tropics","author":"The Project Wolbachia\u2014Singapore Consortium","year":"2021","journal-title":"medRxiv"},{"key":"pcbi.1010755.ref010","doi-asserted-by":"crossref","first-page":"e1003327","DOI":"10.1371\/journal.pcbi.1003327","article-title":"Heterogeneity, mixing, and the spatial scales of mosquito-borne pathogen transmission","volume":"9","author":"TA Perkins","year":"2013","journal-title":"PLoS Computational Biology"},{"key":"pcbi.1010755.ref011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-7-276","article-title":"A global assembly of adult female mosquito mark-release-recapture data to inform the control of mosquito-borne pathogens","volume":"7","author":"CA Guerra","year":"2014","journal-title":"Parasites & 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