{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:18:59Z","timestamp":1772173139348,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010898","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Council of Finland","award":["336033"],"award-info":[{"award-number":["336033"]}]},{"name":"Research Council of Finland","award":["352986"],"award-info":[{"award-number":["352986"]}]},{"name":"Research Council of Finland","award":["358246"],"award-info":[{"award-number":["358246"]}]},{"name":"EU H2020","award":["101016775"],"award-info":[{"award-number":["101016775"]}]},{"name":"EU NextGenerationEU"},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2016092"],"award-info":[{"award-number":["2016092"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AHRQ Healthcare-Associated Infections Program","award":["R01HS019388"],"award-info":[{"award-number":["R01HS019388"]}]},{"DOI":"10.13039\/100018421","name":"Institute for Clinical and Translational Science, University of California, Irvine","doi-asserted-by":"publisher","award":["NIH UL1 TR000153"],"award-info":[{"award-number":["NIH UL1 TR000153"]}],"id":[{"id":"10.13039\/100018421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) is a major cause of morbidity and mortality. Colonization by MRSA increases the risk of infection and transmission, underscoring the importance of decolonization efforts. However, success of these decolonization protocols varies, raising the possibility that some MRSA strains may be more persistent than others. Here, we studied how the persistence of MRSA colonization correlates with genomic presence of antibiotic resistance genes. Our analysis using a Bayesian mixed effects survival model found that genetic determinants of high-level resistance to mupirocin was strongly associated with failure of the decolonization protocol. However, we did not see a similar effect with genetic resistance to chlorhexidine or other antibiotics. Including strain-specific random effects improved the predictive performance, indicating that some strain characteristics other than resistance also contributed to persistence. Study subject-specific random effects did not improve the model. Our results highlight the need to consider the properties of the colonizing MRSA strain when deciding which treatments to include in the decolonization protocol.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1010898","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T13:52:56Z","timestamp":1698328376000},"page":"e1010898","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bayesian modeling of the impact of antibiotic resistance on the efficiency of MRSA decolonization"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5390-5725","authenticated-orcid":true,"given":"Fanni","family":"Ojala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad R. Abdul","family":"Sater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren G.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"McKinnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan S.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonatan H.","family":"Grad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Marttinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"issue":"3","key":"pcbi.1010898.ref001","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"SYC Tong","year":"2015","journal-title":"Clinical Microbiology Reviews"},{"issue":"1","key":"pcbi.1010898.ref002","first-page":"1","article-title":"Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009\u20132010","volume":"34","author":"DM 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Muthukrishnan","year":"2013","journal-title":"BMC Infectious Diseases"},{"key":"pcbi.1010898.ref015","article-title":"Chlorhexidine and Mupirocin for Clearance of Methicillin Resistant Staphylococcus aureus Colonization After Hospital Discharge: A Secondary Analysis of the CLEAR Trial","author":"LG Miller","year":"2022","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"},{"issue":"4","key":"pcbi.1010898.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1006534","article-title":"A Bayesian model of acquisition and clearance of bacterial colonization incorporating within-host variation","volume":"15","author":"M J\u00e4rvenp\u00e4\u00e4","year":"2019","journal-title":"PLoS Computational Biology"},{"key":"pcbi.1010898.ref017","author":"JP Klein","year":"2014","journal-title":"Handbook of Survival 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