{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:00:14Z","timestamp":1782489614619,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011006","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["Bernstein Award 2014, 01GQ1710"],"award-info":[{"award-number":["Bernstein Award 2014, 01GQ1710"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Memories may be encoded in the brain via strongly interconnected groups of neurons, called assemblies. The concept of Hebbian plasticity suggests that these assemblies are generated through synaptic plasticity, strengthening the recurrent connections within select groups of neurons that receive correlated stimulation. To remain stable in absence of such stimulation, the assemblies need to be self-reinforcing under the plasticity rule. Previous models of such assembly maintenance require additional mechanisms of fast homeostatic plasticity often with biologically implausible timescales. Here we provide a model of neuronal assembly generation and maintenance purely based on spike-timing-dependent plasticity (STDP) between excitatory neurons. It uses irregularly and stochastically spiking neurons and STDP that depresses connections of uncorrelated neurons. We find that assemblies do not grow beyond a certain size, because temporally imprecisely correlated spikes dominate the plasticity in large assemblies. Assemblies in the model can be learned or spontaneously emerge. The model allows for prominent, stable overlap structures between static assemblies. Further, assemblies can drift, particularly according to a novel, transient overlap-based mechanism. Finally the model indicates that assemblies grow in the aging brain, where connectivity decreases.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011006","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T13:40:23Z","timestamp":1681306823000},"page":"e1011006","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Purely STDP-based assembly dynamics: Stability, learning, overlaps, drift and 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