{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:20:04Z","timestamp":1772173204324,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011187","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000}}],"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M01116X\/1"],"award-info":[{"award-number":["BB\/M01116X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"crossref","award":["GCRF EP\/R512916\/1"],"award-info":[{"award-number":["GCRF EP\/R512916\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Quarantine has been long used as a public health response to emerging infectious diseases, particularly at the onset of an epidemic when the infected proportion of a population remains identifiable and logistically tractable. In theory, the same logic should apply to low-incidence infections; however, the application and impact of quarantine in low prevalence settings appears less common and lacks a formal analysis. Here, we present a quantitative framework using a series of progressively more biologically realistic models of canine rabies in domestic dogs and from dogs to humans, a suitable example system to characterize dynamical changes under varying levels of dog quarantine. We explicitly incorporate health-seeking behaviour data to inform the modelling of contact-tracing and exclusion of rabies suspect and probable dogs that can be identified through bite-histories of patients presenting at anti-rabies clinics. We find that a temporary quarantine of rabies suspect and probable dogs provides a powerful tool to curtail rabies transmission, especially in settings where optimal vaccination coverage is yet to be achieved, providing a critical stopgap to reduce the number of human and animal deaths due to rabid bites. We conclude that whilst comprehensive measures including sensitive surveillance and large-scale vaccination of dogs will be required to achieve disease elimination and sustained freedom given the persistent risk of rabies re-introductions, quarantine offers a low-cost community driven solution to intersectoral health burden.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011187","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T13:43:20Z","timestamp":1702647800000},"page":"e1011187","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of dynamical changes of rabies transmission under quarantine: Community-based measures towards rabies elimination"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3475-931X","authenticated-orcid":true,"given":"Kristyna","family":"Rysava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Tildesley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"pcbi.1011187.ref001","first-page":"655","volume-title":"Modeling canine rabies virus transmission dynamics","author":"M Rajeev","year":"2020","edition":"4"},{"key":"pcbi.1011187.ref002","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1126\/science.abn0713","article-title":"Rabies shows how scale of transmission can enable acute infections to persist at low prevalence","volume":"376","author":"R Mancy","year":"2022","journal-title":"Science"},{"issue":"8","key":"pcbi.1011187.ref003","doi-asserted-by":"crossref","first-page":"e828","DOI":"10.1016\/S2214-109X(18)30302-4","article-title":"New global strategic plan to eliminate dog-mediated rabies by 2030","volume":"6","author":"R Minghui","year":"2018","journal-title":"The Lancet Global Health"},{"key":"pcbi.1011187.ref004","unstructured":"WHO. Zero by 30: the global strategic plan to end human deaths from dog-mediated rabies by 2030.; 2018. 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