{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:12:07Z","timestamp":1774973527969,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011287","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"US Federal Aid in Wildlife Restoration Act under Michigan Pittman-Robertson Project W-147-R","award":["WLD2009"],"award-info":[{"award-number":["WLD2009"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Many pathogens of humans and livestock also infect wildlife that can act as a reservoir and challenge disease control or elimination. Efficient and effective prioritization of research and management actions requires an understanding of the potential for new tools to improve elimination probability with feasible deployment strategies that can be implemented at scale. Wildlife vaccination is gaining interest as a tool for managing several wildlife diseases. To evaluate the effect of vaccinating white-tailed deer (<jats:italic>Odocoileus virginianus<\/jats:italic>), in combination with harvest, in reducing and eliminating bovine tuberculosis from deer populations in Michigan, we developed a mechanistic age-structured disease transmission model for bovine tuberculosis with integrated disease management. We evaluated the impact of pulse vaccination across a range of vaccine properties. Pulse vaccination was effective for reducing disease prevalence rapidly with even low (30%) to moderate (60%) vaccine coverage of the susceptible and exposed deer population and was further improved when combined with increased harvest. The impact of increased harvest depended on the relative strength of transmission modes, i.e., direct vs indirect transmission. Vaccine coverage and efficacy were the most important vaccine properties for reducing and eliminating disease from the local population. By fitting the model to the core endemic area of bovine tuberculosis in Michigan, USA, we identified feasible integrated management strategies involving vaccination and increased harvest that reduced disease prevalence in free-ranging deer. Few scenarios led to disease elimination due to the chronic nature of bovine tuberculosis. A long-term commitment to regular vaccination campaigns, and further research on increasing vaccines efficacy and uptake rate in free-ranging deer are important for disease management.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011287","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:25:43Z","timestamp":1704392743000},"page":"e1011287","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Wildlife vaccination strategies for eliminating bovine tuberculosis in white-tailed deer populations"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-8192","authenticated-orcid":true,"given":"Aakash","family":"Pandey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail B.","family":"Feuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-141X","authenticated-orcid":true,"given":"Melinda","family":"Cosgrove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Duffiney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt C.","family":"VerCauteren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Campa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Pepin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"pcbi.1011287.ref001","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/1365-2664.12084","article-title":"Taming wildlife disease: bridging the gap between science and management","volume":"50","author":"MB Joseph","year":"2013","journal-title":"Journal of Applied Ecology"},{"key":"pcbi.1011287.ref002","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/0300985812467472","article-title":"Wildlife reservoirs of bovine tuberculosis worldwide: Hosts, pathology, surveillance, and control","volume":"50","author":"SD Fitzgerald","year":"2013","journal-title":"Vet Pathol"},{"key":"pcbi.1011287.ref003","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1017\/S0950268813000976","article-title":"Mycobacterium bovis (bovine tuberculosis) infection in North American wildlife: current status and opportunities for mitigation of risks of further infection in wildlife populations","volume":"141","author":"RS Miller","year":"2013","journal-title":"Epidemiol Infect"},{"key":"pcbi.1011287.ref004","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2018.00109","article-title":"Bovine tuberculosis in Britain and Ireland\u2013A perfect storm? 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Lavelle","year":"2016","journal-title":"Preventive Veterinary Medicine."},{"key":"pcbi.1011287.ref043","doi-asserted-by":"crossref","first-page":"e90925","DOI":"10.1371\/journal.pone.0090925","article-title":"Linking bovine tuberculosis on cattle farms to white-tailed deer and environmental variables using bayesian hierarchical analysis","volume":"9","author":"WD Walter","year":"2014","journal-title":"PLOS ONE"},{"key":"pcbi.1011287.ref044","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.vetmic.2011.02.042","article-title":"Management of bovine tuberculosis in Michigan wildlife: Current status and near term prospects","volume":"151","author":"DJ O\u2019Brien","year":"2011","journal-title":"Veterinary Microbiology"},{"key":"pcbi.1011287.ref045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0167-5877(02)00010-7","article-title":"Epidemiology of Mycobacterium bovis in free-ranging white-tailed deer, Michigan, USA, 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Dressel","year":"2017"},{"key":"pcbi.1011287.ref050","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1128\/CVI.00301-12","article-title":"Duration of immunity against Mycobacterium bovis following neonatal vaccination with Bacillus Calmette-Gu\u00e9rin Danish: Significant protection against infection at 12, but not 24, months.","volume":"19","author":"ML Thom","year":"2012","journal-title":"Clinical and Vaccine Immunology."},{"key":"pcbi.1011287.ref051","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3182\/20120711-3-BE-2027.00381","article-title":"An efficient method for structural identifiability analysis of large dynamic systems.","volume":"45","author":"J Karlsson","year":"2012","journal-title":"IFAC Proceedings Volumes"},{"key":"pcbi.1011287.ref052","first-page":"100368","article-title":"Approximate Bayesian computation for infectious disease modelling.","volume":"29","author":"A Minter","year":"2019"},{"key":"pcbi.1011287.ref053","article-title":"lhs","author":"R. 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