{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:04:16Z","timestamp":1773889456306,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011666","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000}}],"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014054","name":"Drugs for Neglected Diseases initiative","doi-asserted-by":"publisher","award":["reference MR\/X020258\/1"],"award-info":[{"award-number":["reference MR\/X020258\/1"]}],"id":[{"id":"10.13039\/501100014054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation Blanceflor Boncompagni Ludovisi"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["213494\/Z\/18\/Z"],"award-info":[{"award-number":["213494\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK National Institute for Health and Care Research Health Protection Research Unit (NIHR HPRU) in Emerging and Zoonotic Infections in partnership with Public Health England","award":["HPRU200907"],"award-info":[{"award-number":["HPRU200907"]}]},{"DOI":"10.13039\/501100011061","name":"French Development Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011061","id-type":"DOI","asserted-by":"crossref"}]},{"name":"M\u00e9decins Sans Fronti\u00e8res International"},{"DOI":"10.13039\/100009131","name":"Swiss Agency for Development and Cooperation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009131","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UK aid"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>The extent to which dengue virus has been circulating globally and especially in Africa is largely unknown. Testing available blood samples from previous cross-sectional serological surveys offers a convenient strategy to investigate past dengue infections, as such serosurveys provide the ideal data to reconstruct the age-dependent immunity profile of the population and to estimate the average per-capita annual risk of infection: the force of infection (FOI), which is a fundamental measure of transmission intensity.<\/jats:p>\n                  <jats:p>In this study, we present a novel methodological approach to inform the size and age distribution of blood samples to test when samples are acquired from previous surveys. The method was used to inform SERODEN, a dengue seroprevalence survey which is currently being conducted in Ghana among other countries utilizing samples previously collected for a SARS-CoV-2 serosurvey.<\/jats:p>\n                  <jats:p>The method described in this paper can be employed to determine sample sizes and testing strategies for different diseases and transmission settings.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011666","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T14:23:04Z","timestamp":1701094984000},"page":"e1011666","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["A simulation-based method to inform serosurvey design for estimating the force of infection using existing blood 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