{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:08:30Z","timestamp":1740143310151,"version":"3.37.3"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000086","name":"Directorate for Mathematical and Physical Sciences","doi-asserted-by":"publisher","award":["DMS 2324962"],"award-info":[{"award-number":["DMS 2324962"]}],"id":[{"id":"10.13039\/100000086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>The endocrine cells of the pituitary gland are electrically active, and <jats:italic>in vivo<\/jats:italic> they form small networks where the bidirectional cell-cell coupling is through gap junctions. Numerous studies of dispersed pituitary cells have shown that typical behaviors are tonic spiking and bursting, the latter being more effective at evoking secretion. In this article, we use mathematical modeling to examine the dynamics of small networks of spiking and bursting pituitary cells. We demonstrate that intrinsic bursting cells are capable of converting intrinsic spikers into bursters, and perform a fast\/slow analysis to show why this occurs. We then demonstrate the sensitivity of network dynamics to the placement of bursting cells within the network, and demonstrate strategies that are most effective at maximizing secretion from the population of cells. This study provides insights into the <jats:italic>in vivo<\/jats:italic> behavior of cells such as the stress-hormone-secreting pituitary corticotrophs that are switched from spiking to bursting by hypothalamic neurohormones. While much is known about the electrical properties of these cells when isolated from the pituitary, how they behave when part of an electrically coupled network has been largely unstudied.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011811","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T18:21:23Z","timestamp":1706638883000},"page":"e1011811","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Conversion of spikers to bursters in pituitary cell networks: Is it better to disperse for maximum exposure or circle the wagons?"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3458-592X","authenticated-orcid":true,"given":"Mehran","family":"Fazli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-2592","authenticated-orcid":true,"given":"Richard","family":"Bertram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"pcbi.1011811.ref001","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1210\/er.2010-0005","article-title":"Ion channels and signaling in the pituitary gland","volume":"31","author":"SS Stojilkovic","year":"2010","journal-title":"Endo Rev"},{"key":"pcbi.1011811.ref002","doi-asserted-by":"crossref","first-page":"33840","DOI":"10.1074\/jbc.M105386200","article-title":"Dependence of pituitary hormone secretion on the pattern of spontaneous voltage-gated calcium influx","volume":"276","author":"F Van Goor","year":"2001","journal-title":"J Biol Chem"},{"key":"pcbi.1011811.ref003","first-page":"E515","article-title":"Is bursting more effective than spiking in evoking pituitary hormone secretion? 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