{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:24:39Z","timestamp":1774945479105,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011815","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000}}],"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL159205"],"award-info":[{"award-number":["R01HL159205"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ULITR000430"],"award-info":[{"award-number":["ULITR000430"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Clinical imaging modalities are a mainstay of modern disease management, but the full utilization of imaging-based data remains elusive. Aortic disease is defined by anatomic scalars quantifying aortic size, even though aortic disease progression initiates complex shape changes. We present an imaging-based geometric descriptor, inspired by fundamental ideas from topology and soft-matter physics that captures dynamic shape evolution. The aorta is reduced to a two-dimensional mathematical surface in space whose geometry is fully characterized by the local principal curvatures. Disease causes deviation from the smooth bent cylindrical shape of normal aortas, leading to a family of highly heterogeneous surfaces of varying shapes and sizes. To deconvolute changes in shape from size, the shape is characterized using integrated Gaussian curvature or total curvature. The fluctuation in total curvature (\n                    <jats:italic>\u03b4K<\/jats:italic>\n                    ) across aortic surfaces captures heterogeneous morphologic evolution by characterizing local shape changes. We discover that aortic morphology evolves with a power-law defined behavior with rapidly increasing\n                    <jats:italic>\u03b4K<\/jats:italic>\n                    forming the hallmark of aortic disease. Divergent\n                    <jats:italic>\u03b4K<\/jats:italic>\n                    is seen for highly diseased aortas indicative of impending topologic catastrophe or aortic rupture. We also show that aortic size (surface area or enclosed aortic volume) scales as a generalized cylinder for all shapes. Classification accuracy for predicting aortic disease state (normal, diseased with successful surgery, and diseased with failed surgical outcomes) is 92.8\u00b11.7%. The analysis of\n                    <jats:italic>\u03b4K<\/jats:italic>\n                    can be applied on any three-dimensional geometric structure and thus may be extended to other clinical problems of characterizing disease through captured anatomic changes.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1011815","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T13:34:51Z","timestamp":1706880891000},"page":"e1011815","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The geometric evolution of aortic dissections: Predicting surgical success using fluctuations in integrated Gaussian curvature"],"prefix":"10.1371","volume":"20","author":[{"given":"Kameel","family":"Khabaz","sequence":"first","affiliation":[]},{"given":"Karen","family":"Yuan","sequence":"additional","affiliation":[]},{"given":"Joseph","family":"Pugar","sequence":"additional","affiliation":[]},{"given":"David","family":"Jiang","sequence":"additional","affiliation":[]},{"given":"Seth","family":"Sankary","sequence":"additional","affiliation":[]},{"given":"Sanjeev","family":"Dhara","sequence":"additional","affiliation":[]},{"given":"Junsung","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Janet","family":"Kang","sequence":"additional","affiliation":[]},{"given":"Nhung","family":"Nguyen","sequence":"additional","affiliation":[]},{"given":"Kathleen","family":"Cao","sequence":"additional","affiliation":[]},{"given":"Newell","family":"Washburn","sequence":"additional","affiliation":[]},{"given":"Nicole","family":"Bohr","sequence":"additional","affiliation":[]},{"given":"Cheong Jun","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Gordon","family":"Kindlmann","sequence":"additional","affiliation":[]},{"given":"Ross","family":"Milner","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-9714","authenticated-orcid":true,"given":"Luka","family":"Pocivavsek","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"issue":"1","key":"pcbi.1011815.ref001","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s13244-017-0581-2","article-title":"Evaluation of the solitary pulmonary nodule: size matters, but do not ignore the power of morphology","volume":"9","author":"A Snoeckx","year":"2018","journal-title":"Insights into Imaging"},{"issue":"5","key":"pcbi.1011815.ref002","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/jcp.31.5.395","article-title":"The morphology of cirrhosis. 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