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Nevertheless, scRNA-seq data suffer from high variations due to the experimental conditions, called batch effects, preventing any aggregated downstream analysis. Adversarial Information Factorization provides a robust batch-effect correction method that does not rely on prior knowledge of the cell types nor a specific normalization strategy while being adapted to any downstream analysis task. It compares to and even outperforms state-of-the-art methods in several scenarios: low signal-to-noise ratio, batch-specific cell types with few cells, and a multi-batches dataset with imbalanced batches and batch-specific cell types. Moreover, it best preserves the relative gene expression between cell types, yielding superior differential expression analysis results. 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