{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:57:29Z","timestamp":1774943849039,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011921","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000}}],"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-128158NB-C22\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2021-128158NB-C22\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CEX2021-001164-M\/10.13039\/501100011033"],"award-info":[{"award-number":["CEX2021-001164-M\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Human Brain Project of the European Union","award":["785907"],"award-info":[{"award-number":["785907"]}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB029813"],"award-info":[{"award-number":["R01EB029813"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS122742 and U24NS12400"],"award-info":[{"award-number":["R01NS122742 and U24NS12400"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>In an ever-changing visual world, animals\u2019 survival depends on their ability to perceive and respond to rapidly changing motion cues. The primary visual cortex (V1) is at the forefront of this sensory processing, orchestrating neural responses to perturbations in visual flow. However, the underlying neural mechanisms that lead to distinct cortical responses to such perturbations remain enigmatic. In this study, our objective was to uncover the neural dynamics that govern V1 neurons\u2019 responses to visual flow perturbations using a biologically realistic computational model. By subjecting the model to sudden changes in visual input, we observed opposing cortical responses in excitatory layer 2\/3 (L2\/3) neurons, namely, depolarizing and hyperpolarizing responses. We found that this segregation was primarily driven by the competition between external visual input and recurrent inhibition, particularly within L2\/3 and L4. This division was not observed in excitatory L5\/6 neurons, suggesting a more prominent role for inhibitory mechanisms in the visual processing of the upper cortical layers. Our findings share similarities with recent experimental studies focusing on the opposing influence of top-down and bottom-up inputs in the mouse primary visual cortex during visual flow perturbations.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011921","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T19:02:31Z","timestamp":1709838151000},"page":"e1011921","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Modeling circuit mechanisms of opposing cortical responses to visual flow perturbations"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-3229","authenticated-orcid":true,"given":"J.","family":"Galv\u00e1n Fraile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Scherr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 J.","family":"Ramasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Arkhipov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Maass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-7038","authenticated-orcid":true,"given":"Claudio R.","family":"Mirasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"pcbi.1011921.ref001","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1146\/annurev.neuro.26.041002.131039","article-title":"Attentional modulation of visual processing","volume":"27","author":"J. H. Reynolds","year":"2004","journal-title":"Annual Review of Neuroscience"},{"issue":"16","key":"pcbi.1011921.ref002","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.cub.2016.06.006","article-title":"Vision guides selection of freeze or flight defense strategies in mice","volume":"26","author":"G. De Franceschi","year":"2016","journal-title":"Current Biology"},{"issue":"22","key":"pcbi.1011921.ref003","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1016\/j.cub.2016.09.009","article-title":"Vision drives accurate approach behavior during prey capture in laboratory mice","volume":"26","author":"J. L. Hoy","year":"2016","journal-title":"Current Biology"},{"issue":"3","key":"pcbi.1011921.ref004","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrn1055","article-title":"Primary visual cortex and visual awareness","volume":"4","author":"F. Tong","year":"2003","journal-title":"Nature Reviews Neuroscience"},{"issue":"10","key":"pcbi.1011921.ref005","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.tins.2021.07.009","article-title":"Probing mechanisms of visual spatial attention in mice","volume":"44","author":"A. Speed","year":"2021","journal-title":"Trends in Neurosciences"},{"issue":"23","key":"pcbi.1011921.ref006","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1016\/j.neuron.2022.08.028","article-title":"Independent response modulation of visual cortical neurons by attentional and behavioral states","volume":"110","author":"T. Kanamori","year":"2022","journal-title":"Neuron"},{"issue":"8","key":"pcbi.1011921.ref007","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/15.8.13","article-title":"Expectations accelerate entry of visual stimuli into awareness","volume":"15","author":"Y. Pinto","year":"2015","journal-title":"Journal of Vision"},{"issue":"1","key":"pcbi.1011921.ref008","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/4580","article-title":"Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects","volume":"2","author":"R. P. Rao","year":"1999","journal-title":"Nature Neuroscience"},{"issue":"2","key":"pcbi.1011921.ref009","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.neuron.2018.10.003","article-title":"Predictive processing: a canonical cortical computation","volume":"100","author":"G. B. Keller","year":"2018","journal-title":"Neuron"},{"issue":"7","key":"pcbi.1011921.ref010","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.cell.2017.05.023","article-title":"Visuomotor coupling shapes the functional development of mouse visual cortex","volume":"169","author":"A. Attinger","year":"2017","journal-title":"Cell"},{"issue":"6","key":"pcbi.1011921.ref011","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.neuron.2020.09.024","article-title":"Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2\/3 Neurons in Mouse Primary Visual Cortex","volume":"108","author":"R. Jordan","year":"2020","journal-title":"Neuron"},{"issue":"7226","key":"pcbi.1011921.ref012","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature07467","article-title":"Neural processing of auditory feedback during vocal practice in a songbird","volume":"457","author":"G. B. Keller","year":"2009","journal-title":"Nature"},{"issue":"5306","key":"pcbi.1011921.ref013","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1126\/science.275.5306.1593","article-title":"A neural substrate of prediction and reward","volume":"275","author":"W. Schultz","year":"1997","journal-title":"Science"},{"issue":"5","key":"pcbi.1011921.ref014","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuron.2012.03.040","article-title":"Sensorimotor mismatch signals in primary visual cortex of the behaving mouse","volume":"74","author":"G. B. Keller","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"pcbi.1011921.ref015","doi-asserted-by":"crossref","first-page":"109772","DOI":"10.1016\/j.celrep.2021.109772","article-title":"Feature selectivity can explain mismatch signals in mouse visual cortex","volume":"37","author":"T. Muzzu","year":"2021","journal-title":"Cell Reports"},{"issue":"4","key":"pcbi.1011921.ref016","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuron.2010.01.033","article-title":"Modulation of visual responses by behavioral state in mouse visual cortex","volume":"65","author":"C. M. Niell","year":"2010","journal-title":"Neuron"},{"issue":"10","key":"pcbi.1011921.ref017","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.cub.2013.04.012","article-title":"Locomotion controls spatial integration in mouse visual cortex","volume":"23","author":"A. Ayaz","year":"2013","journal-title":"Current Biology"},{"issue":"12","key":"pcbi.1011921.ref018","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/nn.3567","article-title":"Integration of visual motion and locomotion in mouse visual cortex","volume":"16","author":"A. B. Saleem","year":"2013","journal-title":"Nature Neuroscience"},{"issue":"12","key":"pcbi.1011921.ref019","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/nn.4385","article-title":"Experience-dependent spatial expectations in mouse visual cortex","volume":"19","author":"A. Fiser","year":"2016","journal-title":"Nature Neuroscience"},{"issue":"2","key":"pcbi.1011921.ref020","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nn.3917","article-title":"The neocortical circuit: themes and variations","volume":"18","author":"K. D. Harris","year":"2015","journal-title":"Nature Neuroscience"},{"key":"pcbi.1011921.ref021","doi-asserted-by":"crossref","first-page":"e57541","DOI":"10.7554\/eLife.57541","article-title":"Learning prediction error neurons in a canonical interneuron circuit","volume":"9","author":"L. Hert\u00e4g","year":"2020","journal-title":"Elife"},{"issue":"13","key":"pcbi.1011921.ref022","doi-asserted-by":"crossref","first-page":"e2115699119","DOI":"10.1073\/pnas.2115699119","article-title":"Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications","volume":"119","author":"L. Hert\u00e4g","year":"2022","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"pcbi.1011921.ref023","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1113\/jphysiol.1959.sp006308","article-title":"Receptive fields of single neurones in the cat\u2019s striate cortex","volume":"148","author":"D. H. Hubel","year":"1959","journal-title":"The Journal of Physiology"},{"issue":"1","key":"pcbi.1011921.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/4.1.1","article-title":"A brief history of the \u201cfeature detector\u201d","volume":"4","author":"K. A. Martin","year":"1994","journal-title":"Cerebral Cortex"},{"issue":"11","key":"pcbi.1011921.ref025","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.cub.2018.04.012","article-title":"A role for mouse primary visual cortex in motion perception","volume":"28","author":"T. Marques","year":"2018","journal-title":"Current Biology"},{"issue":"3","key":"pcbi.1011921.ref026","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"E. Bullmore","year":"2009","journal-title":"Nature Reviews Neuroscience"},{"issue":"44","key":"pcbi.1011921.ref027","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-club organization of the human connectome","volume":"31","author":"M. P. Van Den Heuvel","year":"2011","journal-title":"Journal of Neuroscience"},{"issue":"Supplement 2","key":"pcbi.1011921.ref028","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1073\/pnas.1302855110","article-title":"Dynamics of brain networks in the aesthetic appreciation","volume":"110","author":"C. J. Cela-Conde","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"pcbi.1011921.ref029","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.047","article-title":"Network analysis of murine cortical dynamics implicates untuned neurons in visual stimulus coding","volume":"31","author":"M. Levy","year":"2020","journal-title":"Cell Reports"},{"key":"pcbi.1011921.ref030","first-page":"2021","article-title":"Inhibition-Dominated Rich-Club Shapes Dynamics in Cortical Microcircuits","author":"H. Hafizi","year":"2021","journal-title":"bioRxiv"},{"key":"pcbi.1011921.ref031","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroimage.2017.11.014","article-title":"High frequency neurons determine effective connectivity in neuronal networks","volume":"166","author":"A. Pariz","year":"2018","journal-title":"NeuroImage"},{"issue":"3","key":"pcbi.1011921.ref032","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuron.2020.01.040","article-title":"Systematic integration of structural and functional data into multi-scale models of mouse primary visual cortex","volume":"106","author":"Y. N. Billeh","year":"2020","journal-title":"Neuron"},{"key":"pcbi.1011921.ref033","volume-title":"Perceptual Neuroscience: The Cerebral Cortex","author":"V. B. Mountcastle","year":"1998"},{"key":"pcbi.1011921.ref034","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/neuro.01.1.1.002.2007","article-title":"Functional maps of neocortical local circuitry","volume":"1","author":"A. M. Thomson","year":"2007","journal-title":"Frontiers in Neuroscience"},{"issue":"2","key":"pcbi.1011921.ref035","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2015.09.029","article-title":"Reconstruction and simulation of neocortical microcircuitry","volume":"163","author":"H. Markram","year":"2015","journal-title":"Cell"},{"issue":"7","key":"pcbi.1011921.ref036","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/s41593-019-0417-0","article-title":"Classification of electrophysiological and morphological neuron types in the mouse visual cortex","volume":"22","author":"N. W. Gouwens","year":"2019","journal-title":"Nature Neuroscience"},{"issue":"7599","key":"pcbi.1011921.ref037","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature17192","article-title":"Anatomy and function of an excitatory network in the visual cortex","volume":"532","author":"W. C. A. Lee","year":"2016","journal-title":"Nature"},{"issue":"1","key":"pcbi.1011921.ref038","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41467-017-02717-4","article-title":"Generalized leaky integrate-and-fire models classify multiple neuron types","volume":"9","author":"C. Teeter","year":"2018","journal-title":"Nature Communications"},{"issue":"2","key":"pcbi.1011921.ref039","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1515\/revneuro-2015-0018","article-title":"The multifunctional lateral geniculate nucleus","volume":"27","author":"T. G. Weyand","year":"2016","journal-title":"Reviews in the Neurosciences"},{"issue":"1","key":"pcbi.1011921.ref040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev.neuro.23.1.473","article-title":"Neuronal coding of prediction errors","volume":"23","author":"W. Schultz","year":"2000","journal-title":"Annual Review of Neuroscience"},{"issue":"9","key":"pcbi.1011921.ref041","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/nn.3464","article-title":"Cellular mechanisms of brain state\u2013dependent gain modulation in visual cortex","volume":"16","author":"P. O. Polack","year":"2013","journal-title":"Nature Neuroscience"},{"issue":"7511","key":"pcbi.1011921.ref042","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature13321","article-title":"Equalizing excitation\u2013inhibition ratios across visual cortical neurons","volume":"511","author":"M. Xue","year":"2014","journal-title":"Nature"},{"issue":"2","key":"pcbi.1011921.ref043","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.2517-6161.1977.tb01615.x","article-title":"Modelling spatial patterns","volume":"39","author":"B. D. Ripley","year":"1977","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"key":"pcbi.1011921.ref044","first-page":"2021","article-title":"Distinct neural dynamics underlie the encoding of visual speed in stationary and running mice","author":"E. A. Horrocks","year":"2021","journal-title":"bioRxiv"},{"issue":"11","key":"pcbi.1011921.ref045","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1093\/cercor\/bhs257","article-title":"Differential wiring of layer 2\/3 neurons drives sparse and reliable firing during neocortical development","volume":"23","author":"B. L. Benedetti","year":"2013","journal-title":"Cerebral Cortex"},{"issue":"6","key":"pcbi.1011921.ref046","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/cercor\/bhv099","article-title":"Thalamocortical innervation pattern in mouse auditory and visual cortex: laminar and cell-type specificity","volume":"26","author":"X. Y. Ji","year":"2016","journal-title":"Cerebral Cortex"},{"issue":"7028","key":"pcbi.1011921.ref047","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature03252","article-title":"Excitatory cortical neurons form fine-scale functional networks","volume":"433","author":"Y. Yoshimura","year":"2005","journal-title":"Nature"},{"issue":"6","key":"pcbi.1011921.ref048","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.neuron.2018.10.023","article-title":"Segregated subnetworks of intracortical projection neurons in primary visual cortex","volume":"100","author":"M. H. Kim","year":"2018","journal-title":"Neuron"},{"issue":"2","key":"pcbi.1011921.ref049","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/cercor\/bhaa297","article-title":"Long-range interhemispheric projection neurons show biased response properties and fine-scale local subnetworks in mouse visual cortex","volume":"31","author":"K. M. Hagihara","year":"2021","journal-title":"Cerebral Cortex"},{"key":"pcbi.1011921.ref050","first-page":"2023","article-title":"The mechanics of correlated variability in segregated cortical excitatory subnetworks","author":"A. Negr\u00f3n","year":"2023","journal-title":"bioRxiv"},{"issue":"6","key":"pcbi.1011921.ref051","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.neuron.2010.11.029","article-title":"An embedded subnetwork of highly active neurons in the neocortex","volume":"68","author":"L. Yassin","year":"2010","journal-title":"Neuron"},{"key":"pcbi.1011921.ref052","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fncir.2014.00092","article-title":"Robust quantification of orientation selectivity and direction selectivity","volume":"8","author":"M. Mazurek","year":"2014","journal-title":"Frontiers in Neural Circuits"},{"issue":"4","key":"pcbi.1011921.ref053","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.neuron.2016.09.057","article-title":"Mismatch receptive fields in mouse visual cortex","volume":"92","author":"P. Zmarz","year":"2016","journal-title":"Neuron"},{"issue":"7","key":"pcbi.1011921.ref054","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/nn.4566","article-title":"Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex","volume":"20","author":"D. Hillier","year":"2017","journal-title":"Nature Neuroscience"},{"issue":"3","key":"pcbi.1011921.ref055","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112096","article-title":"Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2\/3 of primary visual cortex","volume":"42","author":"A. Vasilevskaya","year":"2023","journal-title":"Cell Reports"},{"issue":"33","key":"pcbi.1011921.ref056","doi-asserted-by":"crossref","first-page":"e2101043118","DOI":"10.1073\/pnas.2101043118","article-title":"Recurrent dynamics in the cerebral cortex: Integration of sensory evidence with stored knowledge","volume":"118","author":"W. Singer","year":"2021","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"18","key":"pcbi.1011921.ref057","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/j.neuron.2023.08.015","article-title":"Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses","volume":"111","author":"S. M. O\u2019Toole","year":"2023","journal-title":"Neuron"},{"issue":"9","key":"pcbi.1011921.ref058","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nn.3488","article-title":"Tuned thalamic excitation is amplified by visual cortical circuits","volume":"16","author":"A. D. Lien","year":"2013","journal-title":"Nature Neuroscience"},{"issue":"7708","key":"pcbi.1011921.ref059","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41586-018-0148-5","article-title":"Cortical direction selectivity emerges at convergence of thalamic synapses","volume":"558","author":"A. D. Lien","year":"2018","journal-title":"Nature"},{"key":"pcbi.1011921.ref060","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781107447615","volume-title":"Neuronal Dynamics: From Single Neurons to Networks and Models of Cognition","author":"W. Gerstner","year":"2014"},{"key":"pcbi.1011921.ref061","first-page":"1","article-title":"Cortico-cortical feedback engages active dendrites in visual cortex","author":"M. Fi\u00e7ek","year":"2023","journal-title":"Nature"},{"issue":"1","key":"pcbi.1011921.ref062","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tins.2022.09.007","article-title":"Where is the error? Hierarchical predictive coding through dendritic error computation","volume":"46","author":"F. A. Mikulasch","year":"2023","journal-title":"Trends in Neurosciences"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1011921","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000}},{"DOI":"10.1371\/journal.pcbi.1014136","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1011921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:02:58Z","timestamp":1731542578000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1011921"}},"subtitle":[],"editor":[{"given":"Lyle J.","family":"Graham","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1011921","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1011921","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}