{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:08:28Z","timestamp":1785863308573,"version":"3.56.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011956","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000}}],"reference-count":124,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMW","doi-asserted-by":"publisher","award":["10430022010018"],"award-info":[{"award-number":["10430022010018"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>SARS-CoV-2 transmission in indoor spaces, where most infection events occur, depends on the types and duration of human interactions, among others. Understanding how these human behaviours interface with virus characteristics to drive pathogen transmission and dictate the outcomes of non-pharmaceutical interventions is important for the informed and safe use of indoor spaces. To better understand these complex interactions, we developed the Pedestrian Dynamics\u2014Virus Spread model (PeDViS), an individual-based model that combines pedestrian behaviour models with virus spread models incorporating direct and indirect transmission routes. We explored the relationships between virus exposure and the duration, distance, respiratory behaviour, and environment in which interactions between infected and uninfected individuals took place and compared this to benchmark \u2018at risk\u2019 interactions (1.5 metres for 15 minutes). When considering aerosol transmission, individuals adhering to distancing measures may be at risk due to the buildup of airborne virus in the environment when infected individuals spend prolonged time indoors. In our restaurant case, guests seated at tables near infected individuals were at limited risk of infection but could, particularly in poorly ventilated places, experience risks that surpass that of benchmark interactions. Combining interventions that target different transmission routes can aid in accumulating impact, for instance by combining ventilation with face masks. The impact of such combined interventions depends on the relative importance of transmission routes, which is hard to disentangle and highly context dependent. This uncertainty should be considered when assessing transmission risks upon different types of human interactions in indoor spaces. We illustrated the multi-dimensionality of indoor SARS-CoV-2 transmission that emerges from the interplay of human behaviour and the spread of respiratory viruses. A modelling strategy that incorporates this in risk assessments can help inform policy makers and citizens on the safe use of indoor spaces with varying inter-human interactions.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011956","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T14:22:31Z","timestamp":1711635751000},"page":"e1011956","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["The multi-dimensional challenges of controlling respiratory virus transmission in indoor spaces: Insights from the linkage of a microscopic pedestrian simulation and SARS-CoV-2 transmission model"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-1606","authenticated-orcid":true,"given":"B\u00fcsra","family":"Atamer Balkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-303X","authenticated-orcid":true,"given":"Martijn","family":"Sparnaaij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berend","family":"Wouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Boschma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0812-8853","authenticated-orcid":true,"given":"Yangfan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Daamen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart C. 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CO2 and viral load analysis for indoor air quality","volume":"207","author":"I Martinez","year":"2022","journal-title":"Build Environ."},{"key":"pcbi.1011956.ref052","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1145\/3461778.3462030","volume-title":"Designing Interactive Systems Conference, 2021","author":"B Lee","year":"2021"},{"key":"pcbi.1011956.ref053","doi-asserted-by":"crossref","first-page":"129395","DOI":"10.1016\/j.physa.2023.129395","article-title":"Using pedestrian modelling to inform virus transmission mitigation policies: A novel activity scheduling model to enable virus transmission risk assessment in a restaurant environment","volume":"633","author":"M Sparnaaij","year":"2024","journal-title":"Physica A"},{"key":"pcbi.1011956.ref054","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0191-2615(03)00007-9","article-title":"Pedestrian route-choice and activity scheduling theory and models.","volume":"38","author":"SP Hoogendoorn","year":"2004","journal-title":"Trans Res Part B: Methodol."},{"key":"pcbi.1011956.ref055","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.trpro.2014.09.061","article-title":"The Nomad Model: Theory, Developments and Applications.","volume":"2","author":"M Campanella","year":"2014","journal-title":"Transportation Research Procedia"},{"key":"pcbi.1011956.ref056","article-title":"Viral Load of SARS-CoV-2 in Respiratory Aerosols Emitted by COVID-19 Patients while Breathing, Talking, and Singing","author":"KK Coleman","year":"2021","journal-title":"Clin Infect Dis"},{"key":"pcbi.1011956.ref057","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/anae.15475","article-title":"The effect of respiratory activity, non-invasive respiratory support and facemasks on aerosol generation and its relevance to COVID-19.","volume":"76","author":"NM Wilson","year":"2021","journal-title":"Anaesthesia"},{"key":"pcbi.1011956.ref058","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1136\/thoraxjnl-2021-217577","article-title":"Aerosol emission from the respiratory tract: an analysis of aerosol generation from oxygen delivery systems.","volume":"77","author":"FW Hamilton","year":"2022","journal-title":"Thorax."},{"key":"pcbi.1011956.ref059","author":"D M\u00fcrbe","year":"2020"},{"key":"pcbi.1011956.ref060","first-page":"118","article-title":"Exhaled aerosol increases with COVID-19 infection, age, and obesity","author":"DA Edwards","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1011956.ref061","article-title":"COVID-19 Airborne Transmission Tool Available.","author":"CIRES","year":"2020","journal-title":"In: CIRES [Internet]."},{"key":"pcbi.1011956.ref062","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00637-20","article-title":"Effectiveness of Face Masks in Preventing Airborne Transmission of SARS-CoV-2.","volume":"5","author":"H Ueki","year":"2020","journal-title":"mSphere"},{"key":"pcbi.1011956.ref063","article-title":"Face masks help control transmission of COVID-19","author":"HE Clapham","year":"2021","journal-title":"Lancet Digit Health"},{"key":"pcbi.1011956.ref064","article-title":"Airborne Transmission of SARS-CoV-2: What We Know","author":"JM Samet","year":"2021","journal-title":"Clin Infect Dis"},{"key":"pcbi.1011956.ref065","article-title":"Master Question List for COVID-19 (caused by SARS-CoV-2).","author":"Homeland Security","year":"2021","journal-title":"In: Homeland Security\u2014Science and Technology [Internet]."},{"key":"pcbi.1011956.ref066","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1539-6924.2010.01427.x","article-title":"Development of a dose-response model for SARS coronavirus: Dose-response model for SARS-CoV","volume":"30","author":"T Watanabe","year":"2010","journal-title":"Risk Anal"},{"issue":"7831","key":"pcbi.1011956.ref067","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/d41586-020-02821-4","article-title":"Dozens to be deliberately infected with coronavirus in UK \u2018human challenge\u2019 trials.","volume":"568","author":"E. Callaway","year":"2020","journal-title":"Nature"},{"key":"pcbi.1011956.ref068","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe2555","article-title":"Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2.","volume":"12","author":"A Popa","year":"2020","journal-title":"Sci Transl Med."},{"key":"pcbi.1011956.ref069","doi-asserted-by":"crossref","first-page":"eabh1803","DOI":"10.1126\/scitranslmed.abh1803","article-title":"Comment on \u201cGenomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2.\u201d","volume":"13","author":"MA Martin","year":"2021","journal-title":"Sci Transl Med"},{"key":"pcbi.1011956.ref070","doi-asserted-by":"crossref","DOI":"10.1126\/science.abg0821","article-title":"SARS-CoV-2 within-host diversity and transmission","volume":"372","author":"KA Lythgoe","year":"2021","journal-title":"Science"},{"key":"pcbi.1011956.ref071","doi-asserted-by":"crossref","first-page":"e1009849","DOI":"10.1371\/journal.ppat.1009849","article-title":"Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks.","volume":"17","author":"KM Braun","year":"2021","journal-title":"PLoS Pathog."},{"key":"pcbi.1011956.ref072","doi-asserted-by":"crossref","first-page":"e1009373","DOI":"10.1371\/journal.ppat.1009373","article-title":"Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.","volume":"17","author":"KM Braun","year":"2021","journal-title":"PLoS Pathog."},{"issue":"618","key":"pcbi.1011956.ref073","doi-asserted-by":"crossref","first-page":"eabj3222","DOI":"10.1126\/scitranslmed.abj3222","article-title":"Response to comment on \u201cGenomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2.\u201d","volume":"13","author":"MD Nicholson","year":"2021","journal-title":"Sci Transl Med"},{"key":"pcbi.1011956.ref074","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/s41591-020-1092-0","article-title":"Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong","volume":"26","author":"DC Adam","year":"2020","journal-title":"Nat Med"},{"key":"pcbi.1011956.ref075","article-title":"Hygienerichtlijn voor GGD\u2019en.","author":"RIVM","year":"2019","journal-title":"In: RIVM [Internet]."},{"key":"pcbi.1011956.ref076","doi-asserted-by":"crossref","first-page":"e0255322","DOI":"10.1128\/spectrum.02553-22","article-title":"Efficient Direct and Limited Environmental Transmission of SARS-CoV-2 Lineage B.1.22 in Domestic Cats.","author":"NM Gerhards","year":"2023","journal-title":"Microbiol Spectr"},{"key":"pcbi.1011956.ref077","article-title":"Avoiding COVID-19: Aerosol Guidelines","author":"M. Evans","year":"2020","journal-title":"arXiv: 2005.10988 [physics.soc-ph] [Preprint]"},{"key":"pcbi.1011956.ref078","first-page":"118","article-title":"Mechanistic transmission modeling of COVID-19 on the Diamond Princess cruise ship demonstrates the importance of aerosol transmission","author":"P Azimi","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1011956.ref079","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2020.05.042","article-title":"SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract","volume":"182","author":"YJ Hou","year":"2020","journal-title":"Cell"},{"key":"pcbi.1011956.ref080","doi-asserted-by":"crossref","first-page":"847","DOI":"10.4161\/viru.27172","article-title":"Particle size and pathogenicity in the respiratory tract.","volume":"4","author":"RJ Thomas","year":"2013","journal-title":"Virulence"},{"key":"pcbi.1011956.ref081","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev-virology-100114-055135","article-title":"Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution.","volume":"2","author":"MP Zwart","year":"2015","journal-title":"Annu Rev Virol"},{"key":"pcbi.1011956.ref082","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11783-021-1386-6","article-title":"Aerosol transmission, an indispensable route of COVID-19 spread: case study of a department-store cluster.","volume":"15","author":"G Jiang","year":"2021","journal-title":"Front Environ Sci Eng China"},{"key":"pcbi.1011956.ref083","first-page":"2","article-title":"Erratum: Correction of Text in the Article \u201cEvidence of Long-Distance Droplet Transmission of SARS-CoV-2 by Direct Air Flow in a Restaurant in Korea.\u201d","volume":"36","author":"K-S Kwon","year":"2021","journal-title":"J Korean Med Sci"},{"key":"pcbi.1011956.ref084","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3201\/eid2703.204714","article-title":"Genomic Evidence of In-Flight Transmission of SARS-CoV-2 Despite Predeparture Testing","volume":"27","author":"T Swadi","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"pcbi.1011956.ref085","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3201\/eid2701.203480","article-title":"Superspreading event of SARS-CoV-2 infection at a bar, Ho Chi Minh City, Vietnam","volume":"27","author":"NVV Chau","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"pcbi.1011956.ref086","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijid.2020.12.035","article-title":"Possible aerosol transmission of COVID-19 associated with an outbreak in an apartment in Seoul, South Korea, 2020","volume":"104","author":"SE Hwang","year":"2020","journal-title":"Int J Infect Dis"},{"key":"pcbi.1011956.ref087","first-page":"141856","article-title":"Multi-route respiratory infection: when a transmission route may dominate","volume":"752","author":"CX Gao","year":"2020","journal-title":"Sci Total Environ"},{"key":"pcbi.1011956.ref088","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(21)00869-2","article-title":"Ten scientific reasons in support of airborne transmission of SARS-CoV-2","volume":"397","author":"T Greenhalgh","year":"2021","journal-title":"Lancet"},{"key":"pcbi.1011956.ref089","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/ina.12751","article-title":"Transmission of SARS-CoV-2 by inhalation of respiratory aerosol in the Skagit Valley Chorale superspreading event.","volume":"31","author":"SL Miller","year":"2021","journal-title":"Indoor Air."},{"key":"pcbi.1011956.ref090","doi-asserted-by":"crossref","first-page":"14857","DOI":"10.1073\/pnas.2009637117","article-title":"Identifying airborne transmission as the dominant route for the spread of COVID-19","volume":"117","author":"R Zhang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1011956.ref091","first-page":"26","volume-title":"COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? Nature","author":"D. Lewis","year":"2021"},{"key":"pcbi.1011956.ref092","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jinf.2021.05.030","article-title":"Evidence for lack of transmission by close contact and surface touch in a restaurant outbreak of COVID-19.","volume":"83","author":"N Zhang","year":"2021","journal-title":"J Infect."},{"key":"pcbi.1011956.ref093","doi-asserted-by":"crossref","first-page":"128051","DOI":"10.1016\/j.jhazmat.2021.128051","article-title":"Predominant airborne transmission and insignificant fomite transmission of SARS-CoV-2 in a two-bus COVID-19 outbreak originating from the same pre-symptomatic index case","volume":"425","author":"P Cheng","year":"2022","journal-title":"J Hazard Mater"},{"key":"pcbi.1011956.ref094","first-page":"e112","volume-title":"Lancet Infect Dis","author":"MU Mondelli","year":"2021"},{"key":"pcbi.1011956.ref095","doi-asserted-by":"crossref","first-page":"69","DOI":"10.7326\/M20-5008","article-title":"Transmission of SARS-CoV-2: A review of viral, host, and environmental factors","volume":"174","author":"EA Meyerowitz","year":"2021","journal-title":"Ann Intern Med"},{"key":"pcbi.1011956.ref096","doi-asserted-by":"crossref","first-page":"e12976","DOI":"10.1111\/ina.12976","article-title":"Modeling the factors that influence exposure to SARS-CoV-2 on a subway train carriage.","volume":"32","author":"D Miller","year":"2022","journal-title":"Indoor Air."},{"key":"pcbi.1011956.ref097","article-title":"Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols.","volume":"10","author":"PZ Chen","year":"2021","journal-title":"Elife"},{"key":"pcbi.1011956.ref098","volume-title":"Airborne Transmission of SARS-CoV-2: Proceedings of a Workshop \u2013 in brief","author":"National Academies of Sciences, Engineering and Medicine (NASEM)","year":"2020"},{"key":"pcbi.1011956.ref099","doi-asserted-by":"crossref","first-page":"e2216948120","DOI":"10.1073\/pnas.2216948120","article-title":"Airborne disease transmission during indoor gatherings over multiple time scales: Modeling framework and policy implications","volume":"120","author":"AK Dixit","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1011956.ref100","author":"M. Campanella","year":"2009"},{"key":"pcbi.1011956.ref101","author":"MC Campanella","year":"2016","journal-title":"Microscopic modelling of walking behaviour"},{"key":"pcbi.1011956.ref102","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1108\/9780585474601-012","volume-title":"Transportation and Traffic Theory in the 21st Century.","author":"SP Hoogendoorn","year":"2002"},{"issue":"10","key":"pcbi.1011956.ref103","doi-asserted-by":"crossref","first-page":"e652","DOI":"10.1093\/cid\/ciaa1283","article-title":"Coronavirus Disease 2019 Patients in Earlier Stages Exhaled Millions of Severe Acute Respiratory Syndrome Coronavirus 2 Per Hour.","volume":"72","author":"J Ma","year":"2021","journal-title":"Clin Infect Dis"},{"key":"pcbi.1011956.ref104","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s12879-018-3425-x","article-title":"Fomite-mediated transmission as a sufficient pathway: a comparative analysis across three viral pathogens.","volume":"18","author":"ANM Kraay","year":"2018","journal-title":"BMC Infect Dis"},{"key":"pcbi.1011956.ref105","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/j.1365-2672.2010.04814.x","article-title":"Virus transfer between fingerpads and fomites","volume":"109","author":"TR Julian","year":"2010","journal-title":"J Appl Microbiol"},{"key":"pcbi.1011956.ref106","doi-asserted-by":"crossref","first-page":"7875","DOI":"10.1128\/AEM.02576-13","article-title":"Laboratory evidence of norwalk virus contamination on the hands of infected individuals","volume":"79","author":"P Liu","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"pcbi.1011956.ref107","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/15459624.2014.974808","article-title":"Modeling of human viruses on hands and risk of infection in an office workplace using micro-activity data.","volume":"12","author":"PI Beamer","year":"2015","journal-title":"J Occup Environ Hyg"},{"key":"pcbi.1011956.ref108","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ajic.2020.11.013","article-title":"Modeling COVID-19 infection risks for a single hand-to-fomite scenario and potential risk reductions offered by surface disinfection.","volume":"49","author":"AM Wilson","year":"2021","journal-title":"Am J Infect Control"},{"key":"pcbi.1011956.ref109","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.envres.2008.07.010","article-title":"The fraction of total hand surface area involved in young children\u2019s outdoor hand-to-object contacts","volume":"108","author":"W AuYeung","year":"2008","journal-title":"Environ Res"},{"key":"pcbi.1011956.ref110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/ina.12606","article-title":"Hand hygiene and surface cleaning should be paired for prevention of fomite transmission.","volume":"30","author":"H Lei","year":"2020","journal-title":"Indoor 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