{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:02:12Z","timestamp":1776888132754,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012150","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000}}],"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F31HL165881"],"award-info":[{"award-number":["F31HL165881"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000850","name":"National Heart and Lung Institute","doi-asserted-by":"publisher","award":["K01HL143113"],"award-info":[{"award-number":["K01HL143113"]}],"id":[{"id":"10.13039\/501100000850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL96544"],"award-info":[{"award-number":["1R01HL96544"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL105242"],"award-info":[{"award-number":["1R01HL105242"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL121754"],"award-info":[{"award-number":["1R01HL121754"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["8P41GM103426"],"award-info":[{"award-number":["8P41GM103426"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P50GM094503"],"award-info":[{"award-number":["P50GM094503"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020415","name":"Additional Ventures","doi-asserted-by":"publisher","award":["Expansion Award"],"award-info":[{"award-number":["Expansion Award"]}],"id":[{"id":"10.13039\/100020415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009364","name":"Saving Tiny Hearts Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>In patients with dyssynchronous heart failure (DHF), cardiac conduction abnormalities cause the regional distribution of myocardial work to be non-homogeneous. Cardiac resynchronization therapy (CRT) using an implantable, programmed biventricular pacemaker\/defibrillator, can improve the synchrony of contraction between the right and left ventricles in DHF, resulting in reduced morbidity and mortality and increased quality of life. Since regional work depends on wall stress, which cannot be measured in patients, we used computational methods to investigate regional work distributions and their changes after CRT. We used three-dimensional multi-scale patient-specific computational models parameterized by anatomic, functional, hemodynamic, and electrophysiological measurements in eight patients with heart failure and left bundle branch block (LBBB) who received CRT. To increase clinical translatability, we also explored whether streamlined computational methods provide accurate estimates of regional myocardial work.<\/jats:p>\n                  <jats:p>We found that CRT increased global myocardial work efficiency with significant improvements in non-responders. Reverse ventricular remodeling after CRT was greatest in patients with the highest heterogeneity of regional work at baseline, however the efficacy of CRT was not related to the decrease in overall work heterogeneity or to the reduction in late-activated regions of high myocardial work. Rather, decreases in early-activated regions of myocardium performing negative myocardial work following CRT best explained patient variations in reverse remodeling. These findings were also observed when regional myocardial work was estimated using ventricular pressure as a surrogate for myocardial stress and changes in endocardial surface area as a surrogate for strain. These new findings suggest that CRT promotes reverse ventricular remodeling in human dyssynchronous heart failure by increasing regional myocardial work in early-activated regions of the ventricles, where dyssynchrony is specifically associated with hypoperfusion, late systolic stretch, and altered metabolic activity and that measurement of these changes can be performed using streamlined approaches.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012150","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:38:18Z","timestamp":1728567498000},"page":"e1012150","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful cardiac resynchronization therapy reduces negative septal work in patient-specific models of dyssynchronous heart failure"],"prefix":"10.1371","volume":"20","author":[{"given":"Amanda","family":"Craine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-1863","authenticated-orcid":true,"given":"Adarsh","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Villongco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Krummen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv M.","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy C. P.","family":"Kerckhoffs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey H.","family":"Omens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-3274","authenticated-orcid":true,"given":"Francisco","family":"Contijoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"issue":"6","key":"pcbi.1012150.ref001","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/CIRCRESAHA.113.300270","article-title":"Electromechanical dyssynchrony and resynchronization of the failing heart","volume":"113","author":"JA Kirk","year":"2013","journal-title":"Circ Res"},{"issue":"suppl 5","key":"pcbi.1012150.ref002","doi-asserted-by":"crossref","first-page":"v58","DOI":"10.1093\/europace\/eup308","article-title":"What is treatment success in cardiac resynchronization therapy?","volume":"11","author":"PW Foley","year":"2009","journal-title":"Europace"},{"issue":"18","key":"pcbi.1012150.ref003","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/CIRCULATIONAHA.109.910778","article-title":"Agreement is poor among current criteria used to define response to cardiac resynchronization therapy","volume":"121","author":"BK Fornwalt","year":"2010","journal-title":"Circulation"},{"issue":"suppl D","key":"pcbi.1012150.ref004","doi-asserted-by":"crossref","first-page":"D66","DOI":"10.1016\/j.ehjsup.2004.05.019","article-title":"Reverse remodeling in heart failure\u2013fact or fiction?","volume":"6","author":"B. Pieske","year":"2004","journal-title":"European Heart Journal Supplements"},{"issue":"13","key":"pcbi.1012150.ref005","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1161\/CIRCULATIONAHA.106.677005","article-title":"Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline","volume":"116","author":"GB Bleeker","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"pcbi.1012150.ref006","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12265-011-9331-x","article-title":"The \u201cmissing\u201d link between acute hemodynamic effect and clinical response","volume":"5","author":"FW Prinzen","year":"2012","journal-title":"Journal of cardiovascular translational research"},{"issue":"7","key":"pcbi.1012150.ref007","doi-asserted-by":"crossref","first-page":"H996","DOI":"10.1152\/ajpheart.00191.2013","article-title":"Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions","volume":"305","author":"K Russell","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"25","key":"pcbi.1012150.ref008","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1161\/01.CIR.102.25.3053","article-title":"Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block","volume":"102","author":"GS Nelson","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"pcbi.1012150.ref009","doi-asserted-by":"crossref","first-page":"H300","DOI":"10.1152\/ajpheart.1990.259.2.H300","article-title":"Redistribution of myocardial fiber strain and blood flow by asynchronous activation","volume":"259","author":"FW Prinzen","year":"1990","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"pcbi.1012150.ref010","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/jphysiol.1994.sp020209","article-title":"Regional fibre stress-fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart","volume":"477","author":"T Delhaas","year":"1994","journal-title":"The Journal of Physiology"},{"issue":"4","key":"pcbi.1012150.ref011","first-page":"482","article-title":"Myocardial Structural, Perfusion, and Metabolic Correlates of Left Bundle Branch Block Mechanical Derangement in Patients With Dilated Cardiomyopathy A Tagged Cardiac Magnetic Resonance and Positron Emission Tomography Study","volume":"3","author":"PG Masci","year":"2010","journal-title":"Circulation: Cardiovascular Imaging"},{"issue":"6","key":"pcbi.1012150.ref012","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","article-title":"A novel clinical method for quantification of regional left ventricular pressure\u2013strain loop area: a non-invasive index of myocardial work","volume":"33","author":"K Russell","year":"2012","journal-title":"European Heart Journal"},{"key":"pcbi.1012150.ref013","article-title":"A new method for cardiac computed tomography regional function assessment: stretch quantifier for endocardial engraved zones (SQUEEZ)","author":"A Pourmorteza","year":"2012","journal-title":"Circulation-cardiovascular Imaging"},{"issue":"5","key":"pcbi.1012150.ref014","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jcct.2018.05.002","article-title":"Regional myocardial strain measurements from 4DCT in patients with normal LV function","volume":"12","author":"ER McVeigh","year":"2018","journal-title":"Journal of Cardiovascular Computed Tomography"},{"issue":"5","key":"pcbi.1012150.ref015","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s10554-015-0831-7","article-title":"Correlation of CT-based regional cardiac function (SQUEEZ) with myocardial strain calculated from tagged MRI: an experimental study","volume":"32","author":"A Pourmorteza","year":"2016","journal-title":"Int J Cardiovasc Imaging"},{"key":"pcbi.1012150.ref016","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ijcard.2017.08.040","article-title":"A novel method for evaluating regional RV function in the adult congenital heart with low-dose CT and SQUEEZ processing","volume":"249","author":"FJ Contijoch","year":"2017","journal-title":"International Journal of Cardiology"},{"key":"pcbi.1012150.ref017","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jcp.2012.09.015","article-title":"Patient-specific models of cardiac biomechanics","volume":"244","author":"A Krishnamurthy","year":"2013","journal-title":"Journal of Computational Physics"},{"issue":"6","key":"pcbi.1012150.ref018","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.media.2012.06.005","article-title":"An atlas-based geometry pipeline for cardiac Hermite model construction and diffusion tensor reorientation","volume":"16","author":"Y Zhang","year":"2012","journal-title":"Medical Image Analysis"},{"issue":"3","key":"pcbi.1012150.ref019","doi-asserted-by":"crossref","first-page":"H1088","DOI":"10.1152\/ajpheart.00109.2006","article-title":"Alternans and spiral breakup in a human ventricular tissue model","volume":"291","author":"KH ten Tusscher","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"pcbi.1012150.ref020","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.pbiomolbio.2014.06.011","article-title":"Patient-specific modeling of ventricular activation pattern using surface ECG-derived vectorcardiogram in bundle branch block","volume":"115","author":"CT Villongco","year":"2014","journal-title":"Progress in Biophysics and Molecular Biology"},{"issue":"4","key":"pcbi.1012150.ref021","doi-asserted-by":"crossref","first-page":"H1943","DOI":"10.1152\/ajpheart.00444.2004","article-title":"Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model","volume":"288","author":"T Arts","year":"2005","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"2","key":"pcbi.1012150.ref022","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ehjdh\/ztab033","article-title":"Automated cardiac volume assessment and cardiac long- and short-axis imaging plane prediction from electrocardiogram-gated computed tomography volumes enabled by deep learning","volume":"2","author":"Z Chen","year":"2021","journal-title":"European Heart Journal\u2014Digital Health"},{"issue":"4","key":"pcbi.1012150.ref023","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/24748706.2021.1934617","article-title":"Novel 4DCT Method to Measure Regional Left Ventricular Endocardial Shortening Before and After Transcatheter Mitral Valve Implantation","volume":"5","author":"GM Colvert","year":"2021","journal-title":"Structural Heart"},{"key":"pcbi.1012150.ref024","doi-asserted-by":"crossref","first-page":"jez231","DOI":"10.1093\/ehjci\/jez231","article-title":"Regional myocardial work by cardiac magnetic resonance and non-invasive left ventricular pressure: a feasibility study in left bundle branch block","author":"CK Larsen","year":"2019","journal-title":"European Heart Journal\u2014Cardiovascular Imaging"},{"issue":"2","key":"pcbi.1012150.ref025","article-title":"Myocardial Work in Echocardiography","volume":"16","author":"N Marzlin","year":"2023","journal-title":"Circ: Cardiovascular Imaging"},{"key":"pcbi.1012150.ref026","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-319-91932-4_9","volume-title":"Snapshots of Hemodynamics","author":"N Westerhof","year":"2019"},{"issue":"5","key":"pcbi.1012150.ref027","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ehjci\/jev171","article-title":"Three-dimensional echocardiography-based analysis of right ventricular shape in pulmonary arterial hypertension","volume":"17","author":"K Addetia","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"pcbi.1012150.ref028","article-title":"Patient-Specific Models of Dyssynchronous Heart Failure for Assessment of Regional Work in Patients Undergoing Cardiac Resynchronization Therapy","author":"A Craine","year":"2024","journal-title":"Dryad Digital Repository"},{"issue":"9","key":"pcbi.1012150.ref029","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2004.08.016","article-title":"Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy","volume":"44","author":"JJ Bax","year":"2004","journal-title":"Journal of the American College of Cardiology"},{"issue":"8","key":"pcbi.1012150.ref030","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/echo.12165","article-title":"Left Ventricular Dyssynchrony Predicts Clinical Response to CRT\u2013A Long-Term Follow-Up Single-Center Prospective Observational Cohort Study","volume":"30","author":"C Prinz","year":"2013","journal-title":"Echocardiography"},{"issue":"9","key":"pcbi.1012150.ref031","volume":"40","author":"MV Pitzalis","year":"2002","journal-title":"Cardiac Resynchronization Therapy Tailored by Echocardiographic Evaluation of Ventricular Asynchrony"},{"issue":"11","key":"pcbi.1012150.ref032","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/CIRCULATIONAHA.105.538272","article-title":"Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy","volume":"112","author":"CM Yu","year":"2005","journal-title":"Circulation"},{"issue":"9","key":"pcbi.1012150.ref033","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/ehjci\/jex191","article-title":"Role of myocardial constructive work in the identification of responders to CRT","volume":"19","author":"E Galli","year":"2018","journal-title":"European Heart Journal\u2014Cardiovascular Imaging"},{"issue":"2","key":"pcbi.1012150.ref034","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijcard.2013.10.026","article-title":"Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally","volume":"171","author":"A Kyriacou","year":"2014","journal-title":"Int J Cardiol"},{"issue":"6","key":"pcbi.1012150.ref035","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/S0735-1097(99)00068-6","article-title":"Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging","volume":"33","author":"FW Prinzen","year":"1999","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"pcbi.1012150.ref036","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/eurheartj\/ehi008","article-title":"Left bundle branch block induces ventricular remodelling and functional septal hypoperfusion","volume":"26","author":"K Vernooy","year":"2005","journal-title":"Eur Heart J"},{"key":"pcbi.1012150.ref037","first-page":"ehp372","article-title":"Left bundle branch block causes relative but not absolute septal underperfusion during exercise","author":"P Koepfli","year":"2009","journal-title":"Eur Heart J"},{"issue":"5","key":"pcbi.1012150.ref038","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.hrthm.2014.02.014","article-title":"Cardiac resynchronization therapy restored ventricular septal myocardial perfusion and enhanced ventricular remodeling in patients with nonischemic cardiomyopathy presenting with left bundle branch block","volume":"11","author":"M Ogano","year":"2014","journal-title":"Heart Rhythm"},{"key":"pcbi.1012150.ref039","article-title":"Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure","author":"E Nemutlu","year":"2015","journal-title":"Journal of cardiac failure"},{"issue":"3","key":"pcbi.1012150.ref040","doi-asserted-by":"crossref","first-page":"H353","DOI":"10.1152\/ajpheart.00233.2014","article-title":"Timing and magnitude of systolic stretch affect myofilament activation and mechanical work","volume":"307","author":"JR Tangney","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"pcbi.1012150.ref041","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1161\/CIRCGENETICS.108.832345","article-title":"Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level. Circulation","volume":"2","author":"AS Barth","year":"2009","journal-title":"Cardiovascular Genetics"},{"issue":"5","key":"pcbi.1012150.ref042","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ejheart.2008.03.011","article-title":"Effects of cardiac resynchronization therapy on coronary blood flow: Evaluation by transthoracic Doppler echocardiography\u2606","volume":"10","author":"C Valzania","year":"2008","journal-title":"European journal of heart failure"},{"issue":"4","key":"pcbi.1012150.ref043","first-page":"528","article-title":"Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony a computational model","volume":"3","author":"RC Kerckhoffs","year":"2010","journal-title":"Circulation: Heart Failure"},{"issue":"9","key":"pcbi.1012150.ref044","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/eurjhf\/hfp107","article-title":"Septal rebound stretch reflects the functional substrate to cardiac resynchronization therapy and predicts volumetric and neurohormonal response","volume":"11","author":"BW De Boeck","year":"2009","journal-title":"European journal of heart failure"},{"issue":"5","key":"pcbi.1012150.ref045","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1152\/jappl.1974.37.5.771","article-title":"Pressure-length loop: a new method for simultaneous measurement of segmental and total cardiac function","volume":"37","author":"JS Forrester","year":"1974","journal-title":"Journal of Applied Physiology"},{"issue":"11","key":"pcbi.1012150.ref046","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/ehjci\/jev078","article-title":"Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome","volume":"16","author":"E Boe","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"5","key":"pcbi.1012150.ref047","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/ehjci\/jeab096","article-title":"Prognostic implications of left ventricular myocardial work index in patients with ST-segment elevation myocardial infarction and reduced left ventricular ejection fraction","volume":"23","author":"SC Butcher","year":"2022","journal-title":"European Heart Journal\u2014Cardiovascular Imaging"},{"issue":"11","key":"pcbi.1012150.ref048","doi-asserted-by":"crossref","first-page":"115026","DOI":"10.1088\/1361-6560\/ab21f8","article-title":"Non-invasive myocardial performance mapping using 3D echocardiographic stress\u2013strain loops","volume":"64","author":"J Pedrosa","year":"2019","journal-title":"Phys Med Biol"},{"issue":"9","key":"pcbi.1012150.ref049","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/europace\/eus222","article-title":"2012 EHRA\/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management","volume":"14","author":"JC Daubert","year":"2012","journal-title":"Europace"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1012150","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:41:49Z","timestamp":1729604509000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012150"}},"subtitle":[],"editor":[{"given":"Kenneth S.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":49,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1012150","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.13.593804","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]}}}