{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:49:40Z","timestamp":1772282980694,"version":"3.50.1"},"reference-count":125,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","award":["ATIP Pecreaux"],"award-info":[{"award-number":["ATIP Pecreaux"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["ATIP Pecreaux"],"award-info":[{"award-number":["ATIP Pecreaux"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 326-2013"],"award-info":[{"award-number":["ALTF 326-2013"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"plan cancer","award":["BIO2013-02"],"award-info":[{"award-number":["BIO2013-02"]}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["comit\u00e9s d\u2019Ille-et-Vilaine, des deux S\u00e8vres, et du Maine-et-Loire. (no ref number)"],"award-info":[{"award-number":["comit\u00e9s d\u2019Ille-et-Vilaine, des deux S\u00e8vres, et du Maine-et-Loire. (no ref number)"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rennes m\u00e9tropole","award":["AIS"],"award-info":[{"award-number":["AIS"]}]},{"name":"Rennes m\u00e9tropole","award":["AIS"],"award-info":[{"award-number":["AIS"]}]},{"name":"Rennes m\u00e9tropole","award":["AIS"],"award-info":[{"award-number":["AIS"]}]},{"DOI":"10.13039\/501100011697","name":"R\u00e9gion Bretagne","doi-asserted-by":"publisher","award":["AniDyn-MT"],"award-info":[{"award-number":["AniDyn-MT"]}],"id":[{"id":"10.13039\/501100011697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011697","name":"R\u00e9gion Bretagne","doi-asserted-by":"publisher","award":["pRISM"],"award-info":[{"award-number":["pRISM"]}],"id":[{"id":"10.13039\/501100011697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["BM1408"],"award-info":[{"award-number":["BM1408"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    How can inter-individual variability be quantified? Measuring many features per experiment raises the question of choosing them to recapitulate high-dimensional data. Tackling this challenge on spindle elongation phenotypes, we showed that only three typical elongation patterns describe spindle elongation in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    one-cell embryo. These archetypes, automatically extracted from the experimental data using principal component analysis (PCA), accounted for more than 95% of inter-individual variability of more than 1600 experiments across more than 100 different conditions. The two first archetypes were related to spindle average length and anaphasic elongation rate. The third archetype, accounting for 6% of the variability, was novel and corresponded to a transient spindle shortening in late metaphase, reminiscent of kinetochore function-defect phenotypes. Importantly, these three archetypes were robust to the choice of the dataset and were found even considering only non-treated conditions. Thus, the inter-individual differences between genetically perturbed embryos have the same underlying nature as natural inter-individual differences between wild-type embryos, independently of the temperatures. We thus propose that beyond the apparent complexity of the spindle, only three independent mechanisms account for spindle elongation, weighted differently in the various conditions. Interestingly, the spindle-length archetypes covered both metaphase and anaphase, suggesting that spindle elongation in late metaphase is sufficient to predict the late anaphase length. We validated this idea using a machine-learning approach. Finally, given amounts of these three archetypes could represent a quantitative phenotype. To take advantage of this, we set out to predict interacting genes from a seed based on the PCA coefficients. We exemplified this firstly on the role of\n                    <jats:italic>tpxl-1<\/jats:italic>\n                    whose homolog\n                    <jats:italic>tpx2<\/jats:italic>\n                    is involved in spindle microtubule branching, secondly the mechanism regulating metaphase length, and thirdly the central spindle players which set the length at anaphase. We found novel interactors not in public databases but supported by recent experimental publications.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1012330","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T13:32:51Z","timestamp":1725543171000},"page":"e1012330","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling inter-embryo variability in spindle length over time: Towards quantitative phenotype analysis"],"prefix":"10.1371","volume":"20","author":[{"given":"Yann","family":"Le Cunff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-443X","authenticated-orcid":true,"given":"Laurent","family":"Chesneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Pastezeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Pinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Fairbrass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Mercat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruddi","family":"Rodriguez-Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahraa","family":"Alayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abdouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"de Neidhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Costes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lodie","family":"Anjubault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-1322","authenticated-orcid":true,"given":"H\u00e9l\u00e8ne","family":"Bouvrais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"H\u00e9ligon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-4844","authenticated-orcid":true,"given":"Jacques","family":"P\u00e9cr\u00e9aux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"issue":"4","key":"pcbi.1012330.ref001","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1083\/jcb.201807228","article-title":"Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase","volume":"218","author":"CL Fonseca","year":"2019","journal-title":"J Cell Biol"},{"issue":"4","key":"pcbi.1012330.ref002","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1534\/genetics.115.185736","article-title":"Mutation is a sufficient and robust predictor of genetic variation for mitotic spindle traits in Caenorhabditis elegans","volume":"203","author":"R Farhadifar","year":"2016","journal-title":"Genetics"},{"issue":"11","key":"pcbi.1012330.ref003","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.bpj.2018.10.010","article-title":"Microtubule Feedback and LET-99-Dependent Control of Pulling Forces Ensure Robust Spindle Position","volume":"115","author":"H Bouvrais","year":"2018","journal-title":"Biophys J"},{"issue":"2","key":"pcbi.1012330.ref004","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nrm3044","article-title":"Origins of regulated cell-to-cell variability","volume":"12","author":"B Snijder","year":"2011","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"24","key":"pcbi.1012330.ref005","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1091\/mbc.e13-07-0412","article-title":"The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome","volume":"24","author":"M Niepel","year":"2013","journal-title":"Mol Biol Cell"},{"issue":"2","key":"pcbi.1012330.ref006","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2008.09.050","article-title":"Nature, nurture, or chance: stochastic gene expression and its consequences","volume":"135","author":"A Raj","year":"2008","journal-title":"Cell"},{"issue":"5584","key":"pcbi.1012330.ref007","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.1070919","article-title":"Stochastic gene expression in a single cell","volume":"297","author":"MB Elowitz","year":"2002","journal-title":"Science"},{"issue":"7245","key":"pcbi.1012330.ref008","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature08012","article-title":"Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis","volume":"459","author":"SL Spencer","year":"2009","journal-title":"Nature"},{"issue":"7283","key":"pcbi.1012330.ref009","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nature08781","article-title":"Variability in gene expression underlies incomplete penetrance","volume":"463","author":"A Raj","year":"2010","journal-title":"Nature"},{"key":"pcbi.1012330.ref010","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1038\/msb4100070","article-title":"Noise resistance in the spindle assembly checkpoint","volume":"2","author":"A Doncic","year":"2006","journal-title":"Mol Syst Biol"},{"issue":"12","key":"pcbi.1012330.ref011","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.bpj.2013.05.005","article-title":"Dynamical scenarios for chromosome bi-orientation","volume":"104","author":"T Zhang","year":"2013","journal-title":"Biophys J"},{"issue":"5","key":"pcbi.1012330.ref012","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.molcel.2007.11.013","article-title":"Variability and robustness in biomolecular systems","volume":"28","author":"N Barkai","year":"2007","journal-title":"Mol Cell"},{"issue":"1","key":"pcbi.1012330.ref013","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pbiomolbio.2016.08.005","article-title":"Theoretical principles for biology: Variation","volume":"122","author":"M Montevil","year":"2016","journal-title":"Progress in Biophysics & Molecular Biology"},{"issue":"4","key":"pcbi.1012330.ref014","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.copbio.2008.06.011","article-title":"The stochastic nature of biochemical networks","volume":"19","author":"V Shahrezaei","year":"2008","journal-title":"Curr Opin Biotechnol"},{"issue":"1","key":"pcbi.1012330.ref015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cell.2018.07.042","article-title":"Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture","volume":"175","author":"KA Knouse","year":"2018","journal-title":"Cell"},{"issue":"6","key":"pcbi.1012330.ref016","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1083\/jcb.153.6.1209","article-title":"Functional analysis of kinetochore assembly in Caenorhabditis elegans","volume":"153","author":"K Oegema","year":"2001","journal-title":"The Journal of Cell Biology"},{"issue":"19","key":"pcbi.1012330.ref017","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1073\/pnas.1116749109","article-title":"Mechanical impulses can control metaphase progression in a mammalian cell","volume":"109","author":"T Itabashi","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1012330.ref018","doi-asserted-by":"crossref","first-page":"596263","DOI":"10.3389\/fphys.2020.596263","article-title":"Spindle Architectural Features Must Be Considered Along With Cell Size to Explain the Timing of Mitotic Checkpoint Silencing","volume":"11","author":"M Bloomfield","year":"2020","journal-title":"Front Physiol"},{"issue":"1","key":"pcbi.1012330.ref019","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-cancerbio-042616-072231","article-title":"Aneuploidy in Cancer: Seq-ing Answers to Old Questions","volume":"1","author":"KA Knouse","year":"2017","journal-title":"Annual Review of Cancer Biology"},{"issue":"11","key":"pcbi.1012330.ref020","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/ncb2864","article-title":"Determinants of robustness in spindle assembly checkpoint signalling","volume":"15","author":"S Heinrich","year":"2013","journal-title":"Nat Cell Biol"},{"issue":"2","key":"pcbi.1012330.ref021","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10577-020-09646-x","article-title":"Mitotic checkpoint defects: en route to cancer and drug resistance","volume":"29","author":"S Sarkar","year":"2021","journal-title":"Chromosome Res"},{"issue":"1","key":"pcbi.1012330.ref022","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1534\/genetics.118.301367","article-title":"Mitotic Cell Division in Caenorhabditis elegans","volume":"211","author":"L Pintard","year":"2019","journal-title":"Genetics"},{"issue":"6","key":"pcbi.1012330.ref023","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.cub.2014.12.060","article-title":"Scaling, selection, and evolutionary dynamics of the mitotic spindle","volume":"25","author":"R Farhadifar","year":"2015","journal-title":"Current Biology"},{"key":"pcbi.1012330.ref024","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s42003-019-0347-0","article-title":"Stochastic modelling reveals mechanisms of metabolic heterogeneity","volume":"2","author":"MK Tonn","year":"2019","journal-title":"Commun Biol"},{"issue":"1","key":"pcbi.1012330.ref025","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1016\/j.cub.2017.11.058","article-title":"Stochasticity, individuality and behavior","volume":"28","author":"K Honegger","year":"2018","journal-title":"Curr Biol"},{"issue":"4","key":"pcbi.1012330.ref026","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ng.110","article-title":"Stochastic switching as a survival strategy in fluctuating environments","volume":"40","author":"M Acar","year":"2008","journal-title":"Nat Genet"},{"issue":"7032","key":"pcbi.1012330.ref027","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature03353","article-title":"Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans","volume":"434","author":"B S\u00f6nnichsen","year":"2005","journal-title":"Nature"},{"issue":"3","key":"pcbi.1012330.ref028","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrm.2016.162","article-title":"Mitotic spindle assembly in animal cells: a fine balancing act","volume":"18","author":"SL Prosser","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"pcbi.1012330.ref029","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/boc.202000065","article-title":"Mechanisms of spindle assembly and size control","volume":"112","author":"G Guilloux","year":"2020","journal-title":"Biol Cell"},{"issue":"7723","key":"pcbi.1012330.ref030","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41586-018-0518-z","article-title":"Experimental and computational framework for a dynamic protein atlas of human cell division","volume":"561","author":"Y Cai","year":"2018","journal-title":"Nature"},{"issue":"1","key":"pcbi.1012330.ref031","article-title":"Metaphase Spindle Assembly","volume":"6","author":"TM Kapoor","year":"2017","journal-title":"Biology (Basel)"},{"key":"pcbi.1012330.ref032","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev-biophys-060414-034107","article-title":"The Physics of the Metaphase Spindle","volume":"47","author":"D Oriola","year":"2018","journal-title":"Annu Rev Biophys"},{"issue":"11","key":"pcbi.1012330.ref033","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.tcb.2018.07.003","article-title":"The Spindle: Integrating Architecture and Mechanics across Scales","volume":"28","author":"MW Elting","year":"2018","journal-title":"Trends Cell Biol"},{"key":"pcbi.1012330.ref034","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-cellbio-100109-104006","article-title":"Control of Mitotic Spindle Length","volume":"26","author":"G Goshima","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"pcbi.1012330.ref035","doi-asserted-by":"crossref","first-page":"e2005099","DOI":"10.1371\/journal.pbio.2005099","article-title":"Evolution of mitotic spindle behavior during the first asymmetric embryonic division of nematodes","volume":"16","author":"AC Valfort","year":"2018","journal-title":"PLOS Biology"},{"issue":"8","key":"pcbi.1012330.ref036","doi-asserted-by":"crossref","first-page":"R359","DOI":"10.1016\/j.cub.2010.02.054","article-title":"Mitosis: taking the measure of spindle length","volume":"20","author":"DJ Needleman","year":"2010","journal-title":"Curr Biol"},{"issue":"1","key":"pcbi.1012330.ref037","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/msb.2008.23","article-title":"Reverse engineering of force integration during mitosis in the Drosophila embryo","volume":"4","author":"R Wollman","year":"2008","journal-title":"Molecular Systems Biology"},{"issue":"1","key":"pcbi.1012330.ref038","doi-asserted-by":"crossref","first-page":"e1601603","DOI":"10.1126\/sciadv.1601603","article-title":"Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast","volume":"3","author":"R Blackwell","year":"2017","journal-title":"Sci Adv"},{"key":"pcbi.1012330.ref039","doi-asserted-by":"crossref","first-page":"e03398","DOI":"10.7554\/eLife.03398","article-title":"Mechanical design principles of a mitotic spindle","volume":"4","author":"JJ Ward","year":"2014","journal-title":"Elife"},{"issue":"1","key":"pcbi.1012330.ref040","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41580-021-00407-0","article-title":"A guide to machine learning for biologists","volume":"23","author":"JG Greener","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"pcbi.1012330.ref041","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/s41587-019-0336-3","article-title":"Visualizing structure and transitions in high-dimensional biological data","volume":"37","author":"KR Moon","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"6","key":"pcbi.1012330.ref042","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1101\/gr.161802.113","article-title":"Inputs drive cell phenotype variability","volume":"24","author":"J Park","year":"2014","journal-title":"Genome Res"},{"issue":"36","key":"pcbi.1012330.ref043","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba9319","article-title":"Live-cell imaging and analysis reveal cell phenotypic transition dynamics inherently missing in snapshot data","volume":"6","author":"W Wang","year":"2020","journal-title":"Sci Adv"},{"issue":"9","key":"pcbi.1012330.ref044","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nmeth.2560","article-title":"A database of Caenorhabditis elegans behavioral phenotypes","volume":"10","author":"E Yemini","year":"2013","journal-title":"Nature Methods"},{"issue":"6920","key":"pcbi.1012330.ref045","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"RS Kamath","year":"2003","journal-title":"Nature"},{"key":"pcbi.1012330.ref046","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2105-12-32","article-title":"Worm Phenotype Ontology: integrating phenotype data within and beyond the C. elegans community","volume":"12","author":"G Schindelman","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"pcbi.1012330.ref047","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1091\/mbc.e09-01-0089","article-title":"Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo","volume":"21","author":"L Lewellyn","year":"2010","journal-title":"Mol Biol Cell"},{"issue":"4","key":"pcbi.1012330.ref048","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.devcel.2017.04.013","article-title":"Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex","volume":"41","author":"DK Cheerambathur","year":"2017","journal-title":"Dev Cell"},{"key":"pcbi.1012330.ref049","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40690","article-title":"BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore","volume":"7","author":"F Edwards","year":"2018","journal-title":"Elife"},{"issue":"8","key":"pcbi.1012330.ref050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cub.2005.03.018","article-title":"The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation","volume":"15","author":"IM Cheeseman","year":"2005","journal-title":"Curr Biol"},{"issue":"2","key":"pcbi.1012330.ref051","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.devcel.2005.07.003","article-title":"Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo","volume":"9","author":"M Srayko","year":"2005","journal-title":"Developmental Cell"},{"issue":"2","key":"pcbi.1012330.ref052","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2012.05.016","article-title":"CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo","volume":"368","author":"EB Espiritu","year":"2012","journal-title":"Dev Biol"},{"issue":"5","key":"pcbi.1012330.ref053","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202111094","article-title":"Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics","volume":"222","author":"D Dang","year":"2023","journal-title":"J Cell Biol"},{"key":"pcbi.1012330.ref054","doi-asserted-by":"crossref","first-page":"103132","DOI":"10.1016\/j.media.2024.103132","article-title":"Mitosis detection, fast and slow: Robust and efficient detection of mitotic figures","volume":"94","author":"M Jahanifar","year":"2024","journal-title":"Med Image Anal"},{"issue":"12","key":"pcbi.1012330.ref055","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/s44222-023-00096-8","article-title":"Artificial intelligence for digital and computational pathology","volume":"1","author":"AH Song","year":"2023","journal-title":"Nature Reviews Bioengineering"},{"key":"pcbi.1012330.ref056","article-title":"Mechanics of the spindle apparatus","author":"E Nazockdast","year":"2020","journal-title":"Semin Cell Dev Biol"},{"key":"pcbi.1012330.ref057","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.semcdb.2021.03.023","article-title":"Anaphase B: Long-standing models meet new concepts","volume":"117","author":"K Vukusic","year":"2021","journal-title":"Semin Cell Dev Biol"},{"issue":"3","key":"pcbi.1012330.ref058","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1007\/s40747-021-00637-x","article-title":"Feature dimensionality reduction: a review","volume":"8","author":"W Jia","year":"2022","journal-title":"Complex & Intelligent Systems"},{"key":"pcbi.1012330.ref059","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-84858-7","volume-title":"The elements of statistical learning: data mining, inference, and prediction","author":"T Hastie","year":"2009","edition":"2"},{"issue":"8","key":"pcbi.1012330.ref060","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.bpj.2016.09.007","article-title":"The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability","volume":"111","author":"J P\u00e9cr\u00e9aux","year":"2016","journal-title":"Biophysical Journal"},{"issue":"21","key":"pcbi.1012330.ref061","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.cub.2006.09.030","article-title":"Spindle Oscillations during Asymmetric Cell Division Require a Threshold Number of Active Cortical Force Generators","volume":"16","author":"J Pecreaux","year":"2006","journal-title":"Current Biology"},{"issue":"5","key":"pcbi.1012330.ref062","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.celrep.2015.01.006","article-title":"Temperature dependence of cell division timing accounts for a shift in the thermal limits of c.elegans and C.briggsae","volume":"10","author":"ML Begasse","year":"2015","journal-title":"Cell Reports"},{"issue":"2","key":"pcbi.1012330.ref063","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.devcel.2018.08.023","article-title":"The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth","volume":"47","author":"S Chaaban","year":"2018","journal-title":"Dev Cell"},{"issue":"3","key":"pcbi.1012330.ref064","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bbrc.2020.06.004","article-title":"The temperature dependence of kinesin motor-protein mechanochemistry","volume":"529","author":"VS Kushwaha","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"pcbi.1012330.ref065","doi-asserted-by":"crossref","first-page":"610899","DOI":"10.3389\/fcell.2021.610899","article-title":"Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior","volume":"9","author":"S Yadav","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"pcbi.1012330.ref066","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/cm.21065","article-title":"Centralspindlin: At the heart of cytokinesis","volume":"69","author":"EA White","year":"2012","journal-title":"Cytoskeleton (Hoboken)"},{"key":"pcbi.1012330.ref067","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0074-7696(08)60059-5","article-title":"Cytokinesis in animal cells","volume":"31","author":"R Rappaport","year":"1971","journal-title":"Int Rev Cytol"},{"issue":"12","key":"pcbi.1012330.ref068","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrm3010","article-title":"Asymmetric cell division: recent developments and their implications for tumour biology","volume":"11","author":"JA Knoblich","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7051","key":"pcbi.1012330.ref069","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nature03823","article-title":"A cytokinesis furrow is positioned by two consecutive signals","volume":"436","author":"H Bringmann","year":"2005","journal-title":"Nature"},{"issue":"2","key":"pcbi.1012330.ref070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.devcel.2014.03.007","article-title":"In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics","volume":"29","author":"B Lacroix","year":"2014","journal-title":"Dev Cell"},{"issue":"5","key":"pcbi.1012330.ref071","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.200707120","article-title":"MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover","volume":"179","author":"L Wordeman","year":"2007","journal-title":"J Cell Biol"},{"issue":"3","key":"pcbi.1012330.ref072","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.semcdb.2010.01.016","article-title":"Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules","volume":"21","author":"SC Ems-McClung","year":"2010","journal-title":"Semin Cell Dev Biol"},{"issue":"4","key":"pcbi.1012330.ref073","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cub.2009.12.050","article-title":"Centrosome Size Sets Mitotic Spindle Length in Caenorhabditis elegans Embryos","volume":"20","author":"G Greenan","year":"2010","journal-title":"Current Biology"},{"issue":"6820","key":"pcbi.1012330.ref074","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/35054572","article-title":"Polarity controls forces governing asymmetric spindle positioning in the caenorhabditis elegans embryo","volume":"409","author":"SW Grill","year":"2001","journal-title":"Nature"},{"key":"pcbi.1012330.ref075","doi-asserted-by":"crossref","first-page":"15288","DOI":"10.1038\/ncomms15288","article-title":"C. elegans chromosomes connect to centrosomes by anchoring into the spindle network","volume":"8","author":"S Redemann","year":"2017","journal-title":"Nat Commun"},{"issue":"14","key":"pcbi.1012330.ref076","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.245464","article-title":"Molecular insight into how gamma-TuRC makes microtubules","volume":"134","author":"A Thawani","year":"2021","journal-title":"J Cell Sci"},{"issue":"1","key":"pcbi.1012330.ref077","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41467-019-14087-0","article-title":"Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation","volume":"11","author":"MR King","year":"2020","journal-title":"Nat Commun"},{"key":"pcbi.1012330.ref078","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43890","article-title":"Spatiotemporal organization of branched microtubule networks","volume":"8","author":"A Thawani","year":"2019","journal-title":"Elife"},{"issue":"Database issue","key":"pcbi.1012330.ref079","doi-asserted-by":"crossref","first-page":"D463","DOI":"10.1093\/nar\/gkp952","article-title":"WormBase: a comprehensive resource for nematode research","volume":"38","author":"TW Harris","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"pcbi.1012330.ref080","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2017.05.028","article-title":"The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin","volume":"169","author":"JB Woodruff","year":"2017","journal-title":"Cell"},{"key":"pcbi.1012330.ref081","doi-asserted-by":"crossref","first-page":"e105432","DOI":"10.15252\/embj.2020105432","article-title":"Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins","author":"Y Steblyanko","year":"2020","journal-title":"EMBO J"},{"issue":"12","key":"pcbi.1012330.ref082","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2007.05.001","article-title":"Kinesin-5 acts as a brake in anaphase spindle elongation","volume":"17","author":"AM Saunders","year":"2007","journal-title":"Curr Biol"},{"issue":"19","key":"pcbi.1012330.ref083","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.cub.2004.09.055","article-title":"SPD-1 is required for the formation of the spindle midzone but is not essential for the completion of cytokinesis in C. elegans embryos","volume":"14","author":"KJ Verbrugghe","year":"2004","journal-title":"Curr Biol"},{"issue":"7002","key":"pcbi.1012330.ref084","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nature02767","article-title":"Cell cycle regulation of central spindle assembly","volume":"430","author":"M Mishima","year":"2004","journal-title":"Nature"},{"issue":"5","key":"pcbi.1012330.ref085","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ncb3150","article-title":"Kinetochore components are required for central spindle assembly","volume":"17","author":"G Maton","year":"2015","journal-title":"Nature Cell Biology"},{"issue":"45","key":"pcbi.1012330.ref086","doi-asserted-by":"crossref","first-page":"15938","DOI":"10.1073\/pnas.0407044101","article-title":"Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongation","volume":"101","author":"I Brust-Mascher","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"pcbi.1012330.ref087","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1083\/jcb.200403036","article-title":"Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes","volume":"166","author":"J Powers","year":"2004","journal-title":"J Cell Biol"},{"key":"pcbi.1012330.ref088","article-title":"Lack of chromokinesin Klp-19 creates a more rigid midzone and affects force transmission during anaphase in C. elegans","author":"V Zimyanin","year":"2023","journal-title":"bioRxiv"},{"key":"pcbi.1012330.ref089","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2156-6-5","article-title":"An automated system for measuring parameters of nematode sinusoidal movement","volume":"6","author":"CJ Cronin","year":"2005","journal-title":"BMC Genetics"},{"issue":"AUG","key":"pcbi.1012330.ref090","first-page":"159","article-title":"Deriving Shape-Based Features for C. elegans Locomotion Using Dimensionality Reduction Methods","volume":"10","author":"B Gyenes","year":"2016","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"13","key":"pcbi.1012330.ref091","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.cub.2009.05.056","article-title":"Compression regulates mitotic spindle length by a mechanochemical switch at the poles","volume":"19","author":"S Dumont","year":"2009","journal-title":"Curr Biol"},{"issue":"6","key":"pcbi.1012330.ref092","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.200610043","article-title":"Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle","volume":"176","author":"KS Brown","year":"2007","journal-title":"J Cell Biol"},{"issue":"4","key":"pcbi.1012330.ref093","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.devcel.2018.04.022","article-title":"Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing","volume":"45","author":"B Lacroix","year":"2018","journal-title":"Dev Cell"},{"issue":"4","key":"pcbi.1012330.ref094","article-title":"Anaphase B","volume":"5","author":"JM Scholey","year":"2016","journal-title":"Biology (Basel)"},{"issue":"18","key":"pcbi.1012330.ref095","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.cub.2009.07.050","article-title":"Cell-Size-Dependent Spindle Elongation in the Caenorhabditis elegans Early Embryo","volume":"19","author":"Y Hara","year":"2009","journal-title":"Current Biology"},{"issue":"11","key":"pcbi.1012330.ref096","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1091\/mbc.E14-12-1577","article-title":"Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner","volume":"26","author":"W Nahaboo","year":"2015","journal-title":"Mol Biol Cell"},{"issue":"1","key":"pcbi.1012330.ref097","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41467-017-01539-8","article-title":"Chromosome segregation occurs by microtubule pushing in oocytes","volume":"8","author":"K Laband","year":"2017","journal-title":"Nat Commun"},{"issue":"19","key":"pcbi.1012330.ref098","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1091\/mbc.E19-01-0074","article-title":"Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B","volume":"30","author":"CH Yu","year":"2019","journal-title":"Mol Biol Cell"},{"issue":"3","key":"pcbi.1012330.ref099","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4161\/cc.7.3.5349","article-title":"Cell Cycle Assembling the spindle midzone in the right place at the right time","volume":"7","author":"A Khmelinskii","year":"2008","journal-title":"Cell Cycle"},{"issue":"2","key":"pcbi.1012330.ref100","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.devcel.2005.07.002","article-title":"An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles","volume":"9","author":"N Ozlu","year":"2005","journal-title":"Dev Cell"},{"issue":"6163","key":"pcbi.1012330.ref101","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1126\/science.1246232","article-title":"Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation","volume":"342","author":"DK Cheerambathur","year":"2013","journal-title":"Science"},{"issue":"2","key":"pcbi.1012330.ref102","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1534\/genetics.119.302105","article-title":"Kinetochore Recruitment of the Spindle and Kinetochore-Associated (Ska) Complex Is Regulated by Centrosomal PP2A in Caenorhabditis elegans","volume":"212","author":"KI Lange","year":"2019","journal-title":"Genetics"},{"issue":"8","key":"pcbi.1012330.ref103","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.4161\/cc.8.8.8150","article-title":"How does a millimeter-sized cell find its center?","volume":"8","author":"M Wuhr","year":"2009","journal-title":"Cell Cycle"},{"key":"pcbi.1012330.ref104","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.semcdb.2021.05.016","article-title":"The metaphase spindle at steady state\u2014Mechanism and functions of microtubule poleward flux","volume":"117","author":"M Barisic","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"pcbi.1012330.ref105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48787","article-title":"Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling","volume":"9","author":"C Edelmaier","year":"2020","journal-title":"Elife"},{"issue":"4","key":"pcbi.1012330.ref106","doi-asserted-by":"crossref","first-page":"e1000028","DOI":"10.1371\/journal.pcbi.1000028","article-title":"Dimensionality and dynamics in the behavior of C. elegans","volume":"4","author":"GJ Stephens","year":"2008","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"pcbi.1012330.ref107","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ygeno.2013.04.010","article-title":"A novel insight into Gene Ontology semantic similarity","volume":"101","author":"Y Xu","year":"2013","journal-title":"Genomics"},{"key":"pcbi.1012330.ref108","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/1471-2105-9-468","article-title":"A relation based measure of semantic similarity for Gene Ontology annotations","volume":"9","author":"B Sheehan","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"pcbi.1012330.ref109","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jbi.2011.11.017","article-title":"Finding disease similarity based on implicit semantic similarity","volume":"45","author":"S Mathur","year":"2012","journal-title":"J Biomed Inform"},{"issue":"4","key":"pcbi.1012330.ref110","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa199","article-title":"Semantic similarity and machine learning with ontologies","volume":"22","author":"M Kulmanov","year":"2021","journal-title":"Briefings in Bioinformatics"},{"key":"pcbi.1012330.ref111","doi-asserted-by":"crossref","first-page":"793091","DOI":"10.1155\/2013\/793091","article-title":"From ontology to semantic similarity: calculation of ontology-based semantic similarity","volume":"2013","author":"M Gan","year":"2013","journal-title":"ScientificWorldJournal"},{"issue":"1","key":"pcbi.1012330.ref112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"issue":"22","key":"pcbi.1012330.ref113","doi-asserted-by":"crossref","first-page":"14988","DOI":"10.1074\/jbc.M709115200","article-title":"The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior","volume":"283","author":"H Lee","year":"2008","journal-title":"J Biol Chem"},{"issue":"26","key":"pcbi.1012330.ref114","first-page":"3093","article-title":"The polarity-induced force imbalance in Caenorhabditis elegans embryos is caused by asymmetric binding rates of dynein to the cortex","volume":"29","author":"R Rodriguez-Garcia","year":"2018","journal-title":"Am Soc Cell Biol"},{"issue":"1","key":"pcbi.1012330.ref115","first-page":"RESEARCH0002","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans","volume":"2","author":"RS Kamath","year":"2001","journal-title":"Genome Biol"},{"issue":"6705","key":"pcbi.1012330.ref116","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/27579","article-title":"Specific interference by ingested dsRNA","volume":"395","author":"L Timmons","year":"1998","journal-title":"Nature"},{"key":"pcbi.1012330.ref117","volume-title":"Cold Spring Harbor monograph series","author":"DL Riddle","year":"1997"},{"key":"pcbi.1012330.ref118","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/B978-0-12-391856-7.00039-1","article-title":"A quantitative method for measuring phototoxicity of a live cell imaging microscope","volume":"506","author":"JY Tinevez","year":"2012","journal-title":"Methods in Enzymology"},{"key":"pcbi.1012330.ref119","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ymeth.2015.10.006","article-title":"Metadata management for high content screening in OMERO","volume":"96","author":"S Li","year":"2016","journal-title":"Methods"},{"issue":"4","key":"pcbi.1012330.ref120","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1016\/S0006-3495(01)75884-5","article-title":"Quantitative comparison of algorithms for tracking single fluorescent particles","volume":"81","author":"MK Cheezum","year":"2001","journal-title":"Biophys J"},{"key":"pcbi.1012330.ref121","doi-asserted-by":"crossref","unstructured":"Pecreaux J, Zimmer C, Olivo-Marin JC. Biophysical active contours for cell tracking I: Tension and bending. In: IEEE International Conference on Image Processing (Icip). IEEE; 2006. p. 1949\u20131952.","DOI":"10.1109\/ICIP.2006.312796"},{"issue":"D1","key":"pcbi.1012330.ref122","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gkaa977","article-title":"The InterPro protein families and domains database: 20 years on","volume":"49","author":"M Blum","year":"2021","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"pcbi.1012330.ref123","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1600-0854.2002.30104.x","article-title":"Metazoan motor models: kinesin superfamily in C. elegans","volume":"3","author":"SS Siddiqui","year":"2002","journal-title":"Traffic"},{"issue":"2","key":"pcbi.1012330.ref124","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/bioinformatics\/btn615","article-title":"AmiGO: online access to ontology and annotation data","volume":"25","author":"S Carbon","year":"2009","journal-title":"Bioinformatics"},{"key":"pcbi.1012330.ref125","first-page":"425","volume-title":"Roles of Cytoplasmic Dynein During Mitosis","author":"KT Vaughan","year":"2012","edition":"1"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T13:34:13Z","timestamp":1725543253000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012330"}},"subtitle":[],"editor":[{"given":"Changbong","family":"Hyeon","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":125,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1012330","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.01.538870","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]}}}