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Sudden strategy adaptations are often linked to insights, considered to be a unique aspect of human cognition tied to complex processes such as creativity or meta-cognitive reasoning. Here, we take a learning perspective and ask whether insight-like behaviour can occur in simple artificial neural networks, even when the models only learn to form input-output associations through gradual gradient descent. We compared learning dynamics in humans and regularised neural networks in a perceptual decision task that included a hidden regularity to solve the task more efficiently. Our results show that only some humans discover this regularity, and that behaviour is marked by a sudden and abrupt strategy switch that reflects an aha-moment. Notably, we find that simple neural networks with a gradual learning rule and a constant learning rate closely mimicked behavioural characteristics of human insight-like switches, exhibiting delay of insight, suddenness and selective occurrence in only some networks. Analyses of network architectures and learning dynamics revealed that insight-like behaviour crucially depended on a regularised gating mechanism and noise added to gradient updates, which allowed the networks to accumulate \u201csilent knowledge\u201d that is initially suppressed by regularised gating. This suggests that insight-like behaviour can arise from gradual learning in simple neural networks, where it reflects the combined influences of noise, gating and regularisation. These results have potential implications for more complex systems, such as the brain, and guide the way for future insight research.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012505","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T17:39:02Z","timestamp":1729532342000},"page":"e1012505","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Abrupt and spontaneous strategy switches emerge in simple regularised neural networks"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-5767","authenticated-orcid":true,"given":"Anika T.","family":"L\u00f6we","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9o","family":"Touzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul 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M, Mehta H, Griffiths TL. Aha! moments correspond to metacognitive prediction errors. PsyArxiv. 2021;.","DOI":"10.31234\/osf.io\/c5v42"},{"issue":"2","key":"pcbi.1012505.ref030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1467-9280.1994.tb00637.x","article-title":"Graph-theoretic confirmation of restructuring during insight","volume":"5","author":"FT Durso","year":"1994","journal-title":"Psychological Science"},{"key":"pcbi.1012505.ref031","unstructured":"Power A, Burda Y, Edwards H, Babuschkin I, Misra V. Grokking: Generalization Beyond Overfitting on Small Algorithmic Datasets. arXiv. 2022; p. 1\u201310."},{"key":"pcbi.1012505.ref032","unstructured":"Saxe AM, McClelland JL, Ganguli S. Exact solutions to the nonlinear dynamics of learning in deep linear neural networks. In: Proceedings of the International Conference on Learning Representations 2014.; 2014. p. 1\u201322."},{"issue":"23","key":"pcbi.1012505.ref033","doi-asserted-by":"crossref","first-page":"11537","DOI":"10.1073\/pnas.1820226116","article-title":"A mathematical theory of semantic development in deep neural networks","volume":"166","author":"AM Saxe","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"pcbi.1012505.ref034","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cognition.2008.11.017","article-title":"A connectionist model of a continuous developmental transition in the balance scale task","volume":"110","author":"AC Schapiro","year":"2009","journal-title":"Cognition"},{"issue":"4","key":"pcbi.1012505.ref035","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrn1076","article-title":"The parallel distributed processing approach to semantic cognition","volume":"4","author":"JL McClelland","year":"2003","journal-title":"Nature Reviews Neuroscience"},{"issue":"7","key":"pcbi.1012505.ref036","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.neuron.2022.01.005","article-title":"Orthogonal representations for robust context-dependent task performance in brains and neural networks","volume":"110","author":"T Flesch","year":"2022","journal-title":"Neuron"},{"issue":"12","key":"pcbi.1012505.ref037","article-title":"On the information bottleneck theory of deep learning","volume":"2019","author":"AM Saxe","year":"2019","journal-title":"Journal of Statistical Mechanics: Theory and Experiment"},{"key":"pcbi.1012505.ref038","doi-asserted-by":"crossref","unstructured":"Bengio Y, Louradour J, Collobert R, Weston J. Curriculum Learning. In: In: Proceedings of International Conference on Machine Learning; 2009. p. 41\u201348. 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An empirical exploration of Recurrent Network architectures. 32nd International Conference on Machine Learning, ICML 2015. 2015;3:2332\u20132340."},{"issue":"7899","key":"pcbi.1012505.ref047","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-022-04428-3","article-title":"A biophysical account of multiplication by a single neuron","volume":"603","author":"LN Groschner","year":"2022","journal-title":"Nature"},{"issue":"6035","key":"pcbi.1012505.ref048","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/317314a0","article-title":"Computational vision and regularization theory","volume":"317","author":"T Poggio","year":"1985","journal-title":"Nature"},{"issue":"Nips 2017","key":"pcbi.1012505.ref049","first-page":"272","article-title":"Cortical microcircuits as gated-recurrent neural networks","volume":"2017-Decem","author":"RP Costa","year":"2017","journal-title":"Advances in Neural Information Processing Systems"},{"issue":"3","key":"pcbi.1012505.ref050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/j.2162-6057.1968.tb00104.x","article-title":"The Remote Associates Test","volume":"2","author":"SA Mednick","year":"1968","journal-title":"The Journal of Creative Behavior"},{"issue":"4","key":"pcbi.1012505.ref051","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3758\/BF03195543","article-title":"Normative data for 144 compound remote associate problems","volume":"35","author":"EM Bowden","year":"2003","journal-title":"Behavior Research Methods, Instruments & Computers"},{"issue":"94","key":"pcbi.1012505.ref052","article-title":"Factorial studies of intelligence","volume":"2","author":"LL Thurstone","year":"1941","journal-title":"Psychometric Monographs"},{"issue":"2","key":"pcbi.1012505.ref053","first-page":"438","article-title":"Memory for order of operations in the acquisition and transfer of sequential cognitive skills","volume":"22","author":"DJ Woltz","year":"1996","journal-title":"Journal of Experimental Psychology: Learning, Menory and Cognition"},{"issue":"6972","key":"pcbi.1012505.ref054","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature02223","article-title":"Sleep inspires insight","volume":"427","author":"U Wagner","year":"2004","journal-title":"Nature"},{"issue":"1","key":"pcbi.1012505.ref055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ymeth.2006.12.004","article-title":"How to investigate insight: A proposal","volume":"42","author":"H Haider","year":"2007","journal-title":"Methods"},{"issue":"1","key":"pcbi.1012505.ref056","doi-asserted-by":"crossref","DOI":"10.5334\/jors.194","article-title":"A random-dot kinematogram for web-based vision research","volume":"6","author":"S Rajananda","year":"2018","journal-title":"Journal of Open Research Software"},{"issue":"10","key":"pcbi.1012505.ref057","first-page":"882","article-title":"Subsequent solution by sudden insight","volume":"17","author":"J Kounios","year":"2006","journal-title":"Psychological Science"},{"key":"pcbi.1012505.ref058","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1075\/aicr.48.17fre","volume-title":"Attention and implicit learning","author":"PA Frensch","year":"2003"},{"issue":"5","key":"pcbi.1012505.ref059","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1007\/s00426-021-01594-3","article-title":"What triggers explicit awareness in implicit sequence learning? Implications from theories of consciousness","volume":"86","author":"S Esser","year":"2022","journal-title":"Psychological Research"},{"issue":"4","key":"pcbi.1012505.ref060","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrn2258","article-title":"Noise in the nervous system","volume":"9","author":"AA Faisal","year":"2008","journal-title":"Nature Reviews Neuroscience"},{"issue":"5","key":"pcbi.1012505.ref061","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.neuron.2021.01.023","article-title":"Behavior needs neural variability","volume":"109","author":"L Waschke","year":"2021","journal-title":"Neuron"},{"issue":"10","key":"pcbi.1012505.ref062","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1111\/j.1460-9568.2008.06486.x","article-title":"Spatial scene representations formed by self-organizing learning in a hippocampal extension of the ventral visual system","volume":"28","author":"ET Rolls","year":"2008","journal-title":"European Journal of Neuroscience"},{"key":"pcbi.1012505.ref063","volume-title":"The Noisy Brain: Stochastic dynamics as a principle of brain function","author":"ET Rolls","year":"2012"},{"issue":"4","key":"pcbi.1012505.ref064","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neubiorev.2013.02.015","article-title":"Neuroscience and Biobehavioral Reviews Moment-to-moment brain signal variability: A next frontier in human brain mapping?","volume":"37","author":"DD Garrett","year":"2013","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"pcbi.1012505.ref065","first-page":"1","article-title":"Mechanisms of Homeostatic Synaptic Plasticity in vivo","volume":"13","author":"Hk Lee","year":"2019","journal-title":"PNAS"},{"issue":"1","key":"pcbi.1012505.ref066","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuron.2013.12.025","article-title":"Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration","volume":"81","author":"G Tononi","year":"2014","journal-title":"Neuron"},{"issue":"6324","key":"pcbi.1012505.ref067","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1126\/science.aah5982","article-title":"Ultrastructural evidence for synaptic scaling across the wake\/sleep cycle","volume":"355","author":"L De Vivo","year":"2017","journal-title":"Science"},{"issue":"5","key":"pcbi.1012505.ref068","doi-asserted-by":"crossref","first-page":"100244","DOI":"10.1016\/j.patter.2021.100244","article-title":"The overfitted brain: Dreams evolved to assist generalization","volume":"2","author":"E Hoel","year":"2021","journal-title":"Patterns"},{"key":"pcbi.1012505.ref069","first-page":"1","article-title":"N2 Sleep Inspires Insight","author":"A L\u00f6we","year":"2024","journal-title":"bioRxiv"},{"issue":"34","key":"pcbi.1012505.ref070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.adj1895","article-title":"Human REM sleep recalibrates neural activity in support of memory formation","volume":"9","author":"JD Lendner","year":"2023","journal-title":"Science Advances"},{"issue":"4","key":"pcbi.1012505.ref071","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1162\/jocn_a_01822","article-title":"Cognitive control as a multivariate optimization problem","volume":"34","author":"H Ritz","year":"2022","journal-title":"Journal of Cognitive Neuroscience"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1012505","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T17:52:57Z","timestamp":1730397177000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012505"}},"subtitle":[],"editor":[{"given":"Tobias U","family":"Hauser","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":71,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1012505","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1012505","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}