{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:03:02Z","timestamp":1769824982599,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012632","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000}}],"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2OD026682, 1U54AG075931 and 1U24CA268108"],"award-info":[{"award-number":["OT2OD026682, 1U54AG075931 and 1U24CA268108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Age prediction based on single cell RNA-Sequencing data (scRNA-Seq) can provide information for patients\u2019 susceptibility to various diseases and conditions. In addition, such analysis can be used to identify aging related genes and pathways. To enable age prediction based on scRNA-Seq data, we developed PolyEN, a new regression model which learns continuous representation for expression over time. These representations are then used by PolyEN to integrate genes to predict an age. Existing and new lung aging data we profiled demonstrated PolyEN\u2019s improved performance over existing methods for age prediction. Our results identified lung epithelial cells as the most significant predictors for non-smokers while lung endothelial cells led to the best chronological age prediction results for smokers.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012632","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T18:55:42Z","timestamp":1734634542000},"page":"e1012632","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting lung aging using scRNA-Seq data"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-4031","authenticated-orcid":true,"given":"Qi","family":"Song","sequence":"first","affiliation":[]},{"given":"Alex","family":"Singh","sequence":"additional","affiliation":[]},{"given":"John E.","family":"McDonough","sequence":"additional","affiliation":[]},{"given":"Taylor S.","family":"Adams","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-9251","authenticated-orcid":true,"given":"Robin","family":"Vos","sequence":"additional","affiliation":[]},{"given":"Ruben","family":"De Man","sequence":"additional","affiliation":[]},{"given":"Greg","family":"Myers","sequence":"additional","affiliation":[]},{"given":"Laurens J.","family":"Ceulemans","sequence":"additional","affiliation":[]},{"given":"Bart M.","family":"Vanaudenaerde","sequence":"additional","affiliation":[]},{"given":"Wim A.","family":"Wuyts","sequence":"additional","affiliation":[]},{"given":"Xiting","family":"Yan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7714-8076","authenticated-orcid":true,"given":"Jonas","family":"Schupp","sequence":"additional","affiliation":[]},{"given":"James S.","family":"Hagood","sequence":"additional","affiliation":[]},{"given":"Naftali","family":"Kaminski","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-6051","authenticated-orcid":true,"given":"Ziv","family":"Bar-Joseph","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"pcbi.1012632.ref001","article-title":"Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells","author":"M Ogrodnik","year":"2019","journal-title":"Aging Cell"},{"key":"pcbi.1012632.ref002","article-title":"Transcription errors induce proteotoxic stress and shorten cellular lifespan","author":"M Vermulst","year":"2015","journal-title":"Nat. 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