{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:32:44Z","timestamp":1774240364183,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012640","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000}}],"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS117405"],"award-info":[{"award-number":["R01NS117405"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-cleared treatment for neuropsychiatric disorders with broad potential for new applications, but the neural circuits that are engaged during TMS are still poorly understood. Recordings of neural activity from the corticospinal tract provide a direct readout of the response of motor cortex to TMS, and therefore a new opportunity to model neural circuit dynamics. The study goal was to use epidural recordings from the cervical spine of human subjects to develop a computational model of a motor cortical macrocolumn through which the mechanisms underlying the response to TMS, including direct and indirect waves, could be investigated. An in-depth sensitivity analysis was conducted to identify important pathways, and machine learning was used to identify common circuit features among these pathways. Sensitivity analysis identified neuron types that preferentially contributed to single corticospinal waves. Single wave preference could be predicted using the average connection probability of all possible paths between the activated neuron type and L5 pyramidal tract neurons (PTNs). For these activations, the total conduction delay of the shortest path to L5 PTNs determined the latency of the corticospinal wave. Finally, there were multiple neuron type activations that could preferentially modulate a particular corticospinal wave. The results support the hypothesis that different pathways of circuit activation contribute to different corticospinal waves with participation of both excitatory and inhibitory neurons. Moreover, activation of both afferents to the motor cortex as well as specific neuron types within the motor cortex initiated different I-waves, and the results were interpreted to propose the cortical origins of afferents that may give rise to certain I-waves. The methodology provides a workflow for performing computationally tractable sensitivity analyses on complex models and relating the results to the network structure to both identify and understand mechanisms underlying the response to acute stimulation.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012640","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T14:26:17Z","timestamp":1733408777000},"page":"e1012640","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-4119","authenticated-orcid":true,"given":"Gene J.","family":"Yu","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6530-1857","authenticated-orcid":true,"given":"Federico","family":"Ranieri","sequence":"additional","affiliation":[]},{"given":"Vincenzo","family":"Di Lazzaro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-763X","authenticated-orcid":true,"given":"Marc A.","family":"Sommer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-065X","authenticated-orcid":true,"given":"Angel V.","family":"Peterchev","sequence":"additional","affiliation":[]},{"given":"Warren M.","family":"Grill","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"issue":"2","key":"pcbi.1012640.ref001","first-page":"474","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014\u20132018).","volume":"131","author":"JP Lefaucheur","journal-title":"Clinical Neurophysiology. 2020 Feb 1"},{"key":"pcbi.1012640.ref002","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.clinph.2022.04.022","article-title":"Transcranial magnetic stimulation of the brain: What is stimulated?\u2013A consensus and critical position paper.","volume":"140","author":"HR Siebner","year":"2022","journal-title":"Clinical Neurophysiology."},{"issue":"4","key":"pcbi.1012640.ref003","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/cne.902960405","article-title":"Descending pathways to the spinal cord, III: Sites of origin of the corticospinal tract","volume":"296","author":"RJ Nudo","year":"1990","journal-title":"Journal of Comparative Neurology"},{"issue":"4","key":"pcbi.1012640.ref004","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.brs.2008.07.004","article-title":"State of the art: Physiology of transcranial motor cortex stimulation","volume":"1","author":"V Di Lazzaro","year":"2008","journal-title":"Brain Stimulation"},{"issue":"4","key":"pcbi.1012640.ref005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.brs.2011.07.008","article-title":"I-wave origin and modulation","volume":"5","author":"V Di Lazzaro","year":"2012","journal-title":"Brain Stimulation"},{"issue":"7","key":"pcbi.1012640.ref006","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00221-020-05764-4","article-title":"I-waves in motor cortex revisited","volume":"238","author":"U. 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