{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:29:55Z","timestamp":1773383395986,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012666","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000}}],"reference-count":99,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["855109"],"award-info":[{"award-number":["855109"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Neuroplasticity refers to functional and structural changes in brain regions in response to healthy and pathological activity. Activity dependent plasticity induced by epileptic activity can involve healthy brain regions into the epileptogenic network by perturbing their excitation\/inhibition balance. In this article, we present a new neural mass model, which accounts for neuroplasticity, for investigating the possible mechanisms underlying the epileptogenic network expansion. Our multiple-timescale model is inspired by physiological calcium-mediated synaptic plasticity and pathological extrasynaptic N-methyl-D-aspartate (NMDA) dependent plasticity dynamics. The model highlights that synaptic plasticity at excitatory connections and structural changes in the inhibitory system can transform a healthy region into a secondary epileptic focus under recurrent seizures and interictal activity occurring in the primary focus. Our results suggest that the latent period of this transformation can provide a window of opportunity to prevent the expansion of epileptogenic networks, formation of an epileptic focus, or other comorbidities associated with epileptic activity.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012666","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T18:38:59Z","timestamp":1733251139000},"page":"e1012666","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expansion of epileptogenic networks via neuroplasticity in neural mass models"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-7953","authenticated-orcid":true,"given":"Elif","family":"K\u00f6ksal-Ers\u00f6z","sequence":"first","affiliation":[]},{"given":"Pascal","family":"Benquet","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-9665","authenticated-orcid":true,"given":"Fabrice","family":"Wendling","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"2","key":"pcbi.1012666.ref001","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrn1327","article-title":"Homeostatic plasticity in the developing nervous system.","volume":"5","author":"GG Turrigiano","year":"2004","journal-title":"Nat Rev Neurosci"},{"issue":"11","key":"pcbi.1012666.ref002","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrn1248","article-title":"The other side of the engram: experience-driven changes in neuronal intrinsic excitability.","volume":"4","author":"W Zhang","year":"2003","journal-title":"Nat Rev Neurosci."},{"issue":"4","key":"pcbi.1012666.ref003","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0166-2236(96)80018-X","article-title":"Metaplasticity: the plasticity of synaptic plasticity","volume":"19","author":"WC Abraham","year":"1996","journal-title":"Trends Neurosci"},{"key":"pcbi.1012666.ref004","article-title":"Structure, function, and plasticity of GABA transporters.","author":"A. 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