{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:17:38Z","timestamp":1791339458096,"version":"4.3.1"},"reference-count":115,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CRC-2016-00106"],"award-info":[{"award-number":["CRC-2016-00106"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Fonds de recherche du Qu\u00e9bec \u2013 Nature et technologies","doi-asserted-by":"publisher","award":["2016-PR-191192"],"award-info":[{"award-number":["2016-PR-191192"]}],"id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2018-06707"],"award-info":[{"award-number":["RGPIN-2018-06707"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-159448"],"award-info":[{"award-number":["PJT-159448"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002914","name":"Concordia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ignore the roles of astrocytes while primarily focusing on neurons. Addressing this oversight, we introduce a biophysical neural mass network model, designed to capture the dynamic interplay between astrocytes and neurons via glutamatergic and GABAergic transmission pathways. This network model proposes that neural dynamics are constrained by a two-layered structural network interconnecting both astrocytic and neuronal populations, allowing us to investigate astrocytes\u2019 modulatory influences on whole-brain activity and emerging functional connectivity patterns. By developing a simulation methodology, informed by bifurcation and multilayer network theories, we demonstrate that the dialogue between astrocytic and neuronal networks manifests over fast\u2013slow fluctuation mechanisms as well as through phase\u2013amplitude connectivity processes. The findings from our research represent a significant leap forward in the modeling of glial-neuronal collaboration, promising deeper insights into their collaborative roles across health and disease states.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012683","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T14:04:13Z","timestamp":1736777053000},"page":"e1012683","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-5569","authenticated-orcid":true,"given":"Oba\u00ef Bin Ka\u2019b","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Grova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Benali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"pcbi.1012683.ref001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-00817-8_1","volume-title":"Computational Glioscience [Internet].","author":"M De Pitt\u00e0","year":"2019"},{"key":"pcbi.1012683.ref002","first-page":"1","volume-title":"Encyclopedia of Computational Neuroscience","author":"M. De Pitt\u00e0","year":"2020"},{"issue":"5","key":"pcbi.1012683.ref003","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s00429-017-1383-5","article-title":"Human astrocytes: structure and functions in the healthy brain.","volume":"222","author":"F Vasile","year":"2017","journal-title":"Brain Struct Funct"},{"issue":"8","key":"pcbi.1012683.ref004","first-page":"e1000909","article-title":"Nonlinear Gap Junctions Enable Long-Distance Propagation of Pulsating Calcium Waves in Astrocyte Networks. Gutkin BS, editor. PLoS Comput Biol","volume":"6","author":"M Goldberg","year":"2010","journal-title":"Internet]"},{"issue":"1","key":"pcbi.1012683.ref005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/glia.23632","article-title":"A roadmap to integrate astrocytes into Systems Neuroscience","volume":"68","author":"V. Kastanenka K","year":"2020","journal-title":"Glia"},{"issue":"2","key":"pcbi.1012683.ref006","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuron.2015.01.014","article-title":"Glial Regulation of the Neuronal Connectome through Local and Long-Distant Communication","volume":"86","author":"RD Fields","year":"2015","journal-title":"Neuron"},{"issue":"September","key":"pcbi.1012683.ref007","first-page":"1","article-title":"Astrocytes\u2014The Ultimate Effectors of Long-Range Neuromodulatory Networks?","volume":"14","author":"AG Pacholko","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"pcbi.1012683.ref008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuron.2012.09.010","article-title":"Neuromodulation of Neuronal Circuits: Back to the Future","volume":"76","author":"E. Marder","year":"2012","journal-title":"Neuron"},{"issue":"3","key":"pcbi.1012683.ref009","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nn.4497","article-title":"Dynamic models of large-scale brain activity","volume":"20","author":"M. Breakspear","year":"2017","journal-title":"Nat Neurosci"},{"key":"pcbi.1012683.ref010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/978-3-030-89439-9_13","article-title":"Whole-Brain Modelling: Past, Present, and Future","author":"JD Griffiths","year":"2022","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"1","key":"pcbi.1012683.ref011","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13408-016-0042-0","article-title":"A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model.","volume":"6","author":"A Garnier","year":"2016","journal-title":"The Journal of Mathematical Neuroscience"},{"issue":"2","key":"pcbi.1012683.ref012","doi-asserted-by":"crossref","first-page":"e0147292","DOI":"10.1371\/journal.pone.0147292","article-title":"A New Computational Model for Neuro-Glio-Vascular Coupling: Astrocyte Activation Can Explain Cerebral Blood Flow Nonlinear Response to Interictal Events.","volume":"11","author":"S Blanchard","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"pcbi.1012683.ref013","doi-asserted-by":"crossref","first-page":"e1002293","DOI":"10.1371\/journal.pcbi.1002293","article-title":"A Tale of Two Stories: Astrocyte Regulation of Synaptic Depression and Facilitation. Gutkin BS, editor.","volume":"7","author":"M De Pitt\u00e0","year":"2011","journal-title":"PLoS Comput Biol [Internet]."},{"key":"pcbi.1012683.ref014","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/978-3-030-00817-8_16","volume-title":"Computational Glioscience [Internet].","author":"T Manninen","year":"2019"},{"key":"pcbi.1012683.ref015","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-3-030-00817-8_7","volume-title":"Computational Glioscience [Internet].","author":"J Lallouette","year":"2019"},{"issue":"3","key":"pcbi.1012683.ref016","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pneurobio.2008.08.002","article-title":"GABA, a forgotten gliotransmitter","volume":"86","author":"MC Angulo","year":"2008","journal-title":"Prog Neurobiol"},{"issue":"DEC","key":"pcbi.1012683.ref017","first-page":"1","article-title":"GABA as a rising gliotransmitter.","volume":"8","author":"BE Yoon","year":"2014","journal-title":"Front Neural Circuits [Internet]."},{"key":"pcbi.1012683.ref018","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/978-3-030-00817-8_11","volume-title":"Computational Glioscience [Internet].","author":"V Volman","year":"2019"},{"key":"pcbi.1012683.ref019","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.732820","article-title":"The \u201cNeuro-Glial-Vascular\u201d Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction.","volume":"9","author":"EC Kugler","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"pcbi.1012683.ref020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41593-019-0367-6","article-title":"Astrocytes usurp neurons as a disease focus","volume":"22","author":"SA Liddelow","year":"2019","journal-title":"Nat Neurosci"},{"issue":"1984","key":"pcbi.1012683.ref021","first-page":"1","article-title":"Neuromodulatory connectivity defines the structure of a behavioral neural network","volume":"6","author":"F Diao","year":"2017","journal-title":"Elife"},{"key":"pcbi.1012683.ref022","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.eurpsy.2017.11.007","article-title":"TRIMAGE: A dedicated trimodality (PET\/MR\/EEG) imaging tool for schizophrenia.","volume":"50","author":"A Del Guerra","year":"2018","journal-title":"European Psychiatry [Internet]."},{"issue":"7","key":"pcbi.1012683.ref023","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.tics.2019.04.002","article-title":"Neuromodulatory Influences on Integration and Segregation in the Brain.","volume":"23","author":"JM Shine","year":"2019","journal-title":"Trends Cogn Sci"},{"issue":"2","key":"pcbi.1012683.ref024","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41593-018-0312-0","article-title":"Human cognition involves the dynamic integration of neural activity and neuromodulatory systems","volume":"22","author":"JM Shine","year":"2019","journal-title":"Nat Neurosci"},{"issue":"17","key":"pcbi.1012683.ref025","doi-asserted-by":"crossref","first-page":"9566","DOI":"10.1073\/pnas.1921475117","article-title":"Dynamic coupling of whole-brain neuronal and neurotransmitter systems","volume":"117","author":"ML Kringelbach","year":"2020","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"pcbi.1012683.ref026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s11689-020-09351-0","article-title":"Associations between sensory processing and electrophysiological and neurochemical measures in children with ASD: an EEG-MRS study.","volume":"13","author":"S Pierce","year":"2021","journal-title":"J Neurodev Disord [Internet]."},{"key":"pcbi.1012683.ref027","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/acprof:oso\/9780198524243.003.0010","volume-title":"Beyond Neurotransmission: Neuromodulation and its Importance for Information Processing [Internet].","author":"PS Katz","year":"1999"},{"key":"pcbi.1012683.ref028","doi-asserted-by":"crossref","first-page":"119813","DOI":"10.1016\/j.neuroimage.2022.119813","article-title":"A mean-field model of glutamate and GABA synaptic dynamics for functional MRS.","volume":"266","author":"CA Lea-Carnall","year":"2023","journal-title":"Neuroimage [Internet]."},{"issue":"9","key":"pcbi.1012683.ref029","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41380-019-0426-0","article-title":"Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders","volume":"24","author":"VS Sohal","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"6843","key":"pcbi.1012683.ref030","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/35084005","article-title":"Neurophysiological investigation of the basis of the fMRI signal","volume":"412","author":"NK Logothetis","year":"2001","journal-title":"Nature"},{"issue":"40","key":"pcbi.1012683.ref031","doi-asserted-by":"crossref","first-page":"16783","DOI":"10.1073\/pnas.1112685108","article-title":"Investigating the electrophysiological basis of resting state networks using magnetoencephalography","volume":"108","author":"MJ Brookes","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"pcbi.1012683.ref032","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/nn.3101","article-title":"Large-scale cortical correlation structure of spontaneous oscillatory activity","volume":"15","author":"JF Hipp","year":"2012","journal-title":"Nat Neurosci"},{"issue":"April","key":"pcbi.1012683.ref033","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuroimage.2017.04.030","article-title":"Combined fMRI-MRS acquires simultaneous glutamate and BOLD-fMRI signals in the human brain","volume":"155","author":"IB Ip","year":"2017","journal-title":"Neuroimage"},{"key":"pcbi.1012683.ref034","first-page":"118788","article-title":"Connectomics of human electrophysiology.","author":"S Sadaghiani","year":"2021","journal-title":"Neuroimage [Internet]."},{"issue":"4","key":"pcbi.1012683.ref035","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1460-9568.2010.07584.x","article-title":"The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals.","volume":"33","author":"CR Figley","year":"2011","journal-title":"European Journal of Neuroscience"},{"issue":"19","key":"pcbi.1012683.ref036","doi-asserted-by":"crossref","first-page":"E2675","DOI":"10.1073\/pnas.1520759113","article-title":"Astrocytes regulate cortical state switching in vivo","volume":"113","author":"KE Poskanzer","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7","key":"pcbi.1012683.ref037","doi-asserted-by":"crossref","first-page":"E1647","DOI":"10.1073\/pnas.1711692115","article-title":"Brain-state dependent astrocytic Ca 2+ signals are coupled to both positive and negative BOLD-fMRI signals","volume":"115","author":"M Wang","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"October","key":"pcbi.1012683.ref038","first-page":"1","article-title":"Origins of the Resting-State Functional MRI Signal: Potential Limitations of the \u201cNeurocentric\u201d Model.","volume":"13","author":"H Lu","year":"2019","journal-title":"Front Neurosci [Internet]."},{"issue":"3","key":"pcbi.1012683.ref039","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nn.4492","article-title":"[18F]FDG PET signal is driven by astroglial glutamate transport","volume":"20","author":"ER Zimmer","year":"2017","journal-title":"Nat Neurosci"},{"issue":"1","key":"pcbi.1012683.ref040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of Astroglia.","volume":"98","author":"A Verkhratsky","year":"2018","journal-title":"Physiol Rev"},{"key":"pcbi.1012683.ref041","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-3-030-00817-8_8","volume-title":"Computational Glioscience [Internet].","author":"C Gonz\u00e1lez-Arias","year":"2019"},{"issue":"12","key":"pcbi.1012683.ref042","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nbt.1711","article-title":"Large-scale in silico modeling of metabolic interactions between cell types in the human brain","volume":"28","author":"NE Lewis","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"April","key":"pcbi.1012683.ref043","doi-asserted-by":"crossref","first-page":"105193","DOI":"10.1016\/j.neubiorev.2023.105193","article-title":"From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging.","volume":"150","author":"T Lawn","year":"2023","journal-title":"Neurosci Biobehav Rev [Internet]."},{"issue":"May","key":"pcbi.1012683.ref044","doi-asserted-by":"crossref","first-page":"120193","DOI":"10.1016\/j.neuroimage.2023.120193","article-title":"Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy","volume":"276","author":"A Jafarian","year":"2023","journal-title":"Neuroimage"},{"issue":"2","key":"pcbi.1012683.ref045","doi-asserted-by":"crossref","first-page":"e1008737","DOI":"10.1371\/journal.pcbi.1008737","article-title":"Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models.","volume":"17","author":"C Coronel-Oliveros","year":"2021","journal-title":"PLoS Comput Biol [Internet]."},{"key":"pcbi.1012683.ref046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.31130","article-title":"The modulation of neural gain facilitates a transition between functional segregation and integration in the brain","volume":"7","author":"JM Shine","year":"2018","journal-title":"Elife"},{"issue":"December","key":"pcbi.1012683.ref047","first-page":"1","article-title":"Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments.","volume":"11","author":"MC Avery","year":"2017","journal-title":"Front Neural Circuits [Internet]."},{"issue":"11","key":"pcbi.1012683.ref048","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41593-022-01186-3","article-title":"Mapping neurotransmitter systems to the structural and functional organization of the human neocortex","volume":"25","author":"JY Hansen","year":"2022","journal-title":"Nat Neurosci"},{"issue":"4","key":"pcbi.1012683.ref049","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/cercor\/bhac150","article-title":"Metabolic and functional connectivity provide unique and complementary insights into cognition-connectome relationships","volume":"33","author":"K Voigt","year":"2023","journal-title":"Cerebral Cortex"},{"issue":"1","key":"pcbi.1012683.ref050","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1038\/s41467-023-41689-6","article-title":"Neurophysiological signatures of cortical micro-architecture.","volume":"14","author":"G Shafiei","year":"2023","journal-title":"Nat Commun [Internet]."},{"issue":"10","key":"pcbi.1012683.ref051","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"MD Sweeney","year":"2018","journal-title":"Nat Neurosci"},{"key":"pcbi.1012683.ref052","article-title":"All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer\u2019s disease.","volume":"16","author":"MK St-Pierre","year":"2022","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"pcbi.1012683.ref053","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41593-021-00904-7","article-title":"Revisiting the neurovascular unit","volume":"24","author":"S Schaeffer","year":"2021","journal-title":"Nat Neurosci"},{"issue":"6","key":"pcbi.1012683.ref054","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive Astrocytes: Production, Function, and Therapeutic Potential.","volume":"46","author":"SA Liddelow","year":"2017","journal-title":"Immunity"},{"issue":"December","key":"pcbi.1012683.ref055","first-page":"1","article-title":"More Than Mortar: Glia as Architects of Nervous System Development and Disease.","volume":"8","author":"I Lago-Baldaia","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"6411","key":"pcbi.1012683.ref056","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"NJ Allen","year":"1979","journal-title":"Science"},{"issue":"1","key":"pcbi.1012683.ref057","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"C. Iadecola","year":"2017","journal-title":"Neuron"},{"issue":"5","key":"pcbi.1012683.ref058","first-page":"1303","article-title":"Astrocytes: new evidence, new models, new roles. Biophys Rev","volume":"15","author":"A Brazhe","year":"2023","journal-title":"Internet]"},{"issue":"1","key":"pcbi.1012683.ref059","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1038\/s41598-023-32618-0","article-title":"Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics.","volume":"13","author":"F Tesler","year":"2023","journal-title":"Sci Rep [Internet]."},{"issue":"7","key":"pcbi.1012683.ref060","doi-asserted-by":"crossref","first-page":"e1010296","DOI":"10.1371\/journal.pcbi.1010296","article-title":"Modelling the modulation of cortical Up-Down state switching by astrocytes.","volume":"18","author":"L Blum Moyse","year":"2022","journal-title":"PLoS Comput Biol [Internet]."},{"key":"pcbi.1012683.ref061","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/978-981-16-8313-8_23","volume-title":"The Biology of Glial Cells: Recent Advances [Internet].","author":"S Sinha","year":"2022"},{"key":"pcbi.1012683.ref062","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cphy.c190022","volume-title":"Comprehensive Physiology [Internet].","author":"S Garofalo","year":"2020"},{"issue":"8","key":"pcbi.1012683.ref063","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/glia.24178","article-title":"Astrocyte regulation of neural circuit activity and network states","volume":"70","author":"JF Oliveira","year":"2022","journal-title":"Glia"},{"issue":"July","key":"pcbi.1012683.ref064","doi-asserted-by":"crossref","first-page":"105008","DOI":"10.1016\/j.nbd.2020.105008","article-title":"Glia: victims or villains of the aging brain","volume":"143","author":"IH Salas","year":"2020","journal-title":"Neurobiol Dis"},{"issue":"May","key":"pcbi.1012683.ref065","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neubiorev.2020.07.039","article-title":"Astroglia-specific contributions to the regulation of synapses, cognition and behaviour","volume":"118","author":"M Augusto-Oliveira","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"pcbi.1012683.ref066","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/1073858413504465","article-title":"Glial Biology in Learning and Cognition.","volume":"20","author":"RD Fields","year":"2014","journal-title":"The Neuroscientist"},{"key":"pcbi.1012683.ref067","first-page":"83","article-title":"The Role of Glia in Sleep Regulation and Function","author":"MG Frank","year":"2018","journal-title":"In: Handbook of Experimental Pharmacology"},{"issue":"1\u20132","key":"pcbi.1012683.ref068","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molmet.2012.07.001","article-title":"Emerging role of glial cells in the control of body weight.","volume":"1","author":"C Garc\u00eda-C\u00e1ceres","year":"2012","journal-title":"Mol Metab [Internet]."},{"issue":"1","key":"pcbi.1012683.ref069","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-neuro-101920-112225","article-title":"Astrocytes and Behavior","volume":"44","author":"P Kofuji","year":"2021","journal-title":"Annu Rev Neurosci"},{"issue":"July","key":"pcbi.1012683.ref070","first-page":"1","article-title":"Glia Crosstalk in Neuroinflammatory Diseases.","volume":"14","author":"A Bernaus","year":"2020","journal-title":"Front Cell Neurosci"},{"issue":"5","key":"pcbi.1012683.ref071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/gix004","article-title":"Multilayer modeling and analysis of human brain networks","volume":"6","author":"M. De Domenico","year":"2017","journal-title":"Gigascience"},{"key":"pcbi.1012683.ref072","first-page":"324","article-title":"Integrating cross-frequency and within band functional networks in resting-state MEG: A multi-layer network approach. Neuroimage","volume":"142","author":"P Tewarie","year":"2016","journal-title":"Internet]"},{"key":"pcbi.1012683.ref073","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroimage.2019.06.006","article-title":"Tracking dynamic brain networks using high temporal resolution MEG measures of functional connectivity","volume":"200","author":"P Tewarie","year":"2019","journal-title":"Neuroimage"},{"issue":"7","key":"pcbi.1012683.ref074","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.clinph.2020.03.031","article-title":"Human brain connectivity: Clinical applications for clinical neurophysiology.","volume":"131","author":"M Hallett","year":"2020","journal-title":"Clinical Neurophysiology"},{"issue":"7965","key":"pcbi.1012683.ref075","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41586-023-06098-1","article-title":"Geometric constraints on human brain function","volume":"618","author":"JC Pang","year":"2023","journal-title":"Nature"},{"key":"pcbi.1012683.ref076","first-page":"379","article-title":"The contribution of geometry to the human connectome. Neuroimage","volume":"124","author":"JA Roberts","year":"2016","journal-title":"Internet]"},{"issue":"4","key":"pcbi.1012683.ref077","doi-asserted-by":"crossref","first-page":"e1010781","DOI":"10.1371\/journal.pcbi.1010781","article-title":"Complex spatiotemporal oscillations emerge from transverse instabilities in large-scale brain networks.","volume":"19","author":"P Clusella","year":"2023","journal-title":"PLoS Comput Biol [Internet]."},{"issue":"2","key":"pcbi.1012683.ref078","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1162\/netn_a_00130","article-title":"The role of node dynamics in shaping emergent functional connectivity patterns in the brain","volume":"4","author":"M Forrester","year":"2020","journal-title":"Network Neuroscience"},{"key":"pcbi.1012683.ref079","first-page":"1898","volume-title":"Encyclopedia of Computational Neuroscience [Internet].","author":"DTJ Liley","year":"2015"},{"issue":"4","key":"pcbi.1012683.ref080","doi-asserted-by":"crossref","first-page":"e0173776","DOI":"10.1371\/journal.pone.0173776","article-title":"A neural mass model of cross frequency coupling.","volume":"12","author":"M Chehelcheraghi","year":"2017","journal-title":"PLoS OneInternet]"},{"key":"pcbi.1012683.ref081","first-page":"1","volume-title":"Nonlinear Dynamics in Computational Neuroscience [Internet].","author":"S Coombes","year":"2019"},{"issue":"4","key":"pcbi.1012683.ref082","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF00199471","article-title":"Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns.","volume":"73","author":"BH Jansen","year":"1995","journal-title":"Biol Cybern [Internet]."},{"key":"pcbi.1012683.ref083","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuroimage.2015.01.002","article-title":"Mathematical framework for large-scale brain network modeling in The Virtual Brain","volume":"111","author":"P Sanz-Leon","year":"2015","journal-title":"Neuroimage"},{"issue":"2","key":"pcbi.1012683.ref084","first-page":"1","article-title":"Neural Field Models: A mathematical overview and unifying framework.","volume":"2","author":"BJ Cook","year":"2022","journal-title":"Mathematical Neuroscience and Applications"},{"issue":"1","key":"pcbi.1012683.ref085","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuroimage.2007.08.001","article-title":"Biophysical model for integrating neuronal activity, EEG, fMRI and metabolism","volume":"39","author":"RC Sotero","year":"2008","journal-title":"Neuroimage"},{"issue":"9","key":"pcbi.1012683.ref086","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/hbm.20704","article-title":"Model driven EEG\/fMRI fusion of brain oscillations.","volume":"30","author":"PA Valdes-Sosa","year":"2009","journal-title":"Hum Brain Mapp"},{"issue":"February","key":"pcbi.1012683.ref087","first-page":"632","article-title":"Ghost interactions in MEG\/EEG source space: A note of caution on inter-areal coupling measures. Neuroimage","volume":"173","author":"JM Palva","year":"2018","journal-title":"Internet]"},{"issue":"4","key":"pcbi.1012683.ref088","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","article-title":"A Cellular Perspective on Brain Energy Metabolism and Functional Imaging","volume":"86","author":"PJ Magistretti","year":"2015","journal-title":"Neuron"},{"issue":"2","key":"pcbi.1012683.ref089","doi-asserted-by":"crossref","first-page":"e1004036","DOI":"10.1371\/journal.pcbi.1004036","article-title":"Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble.","volume":"11","author":"R Jolivet","year":"2015","journal-title":"PLoS Comput Biol [Internet]."},{"issue":"2","key":"pcbi.1012683.ref090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/brain.2012.0120","article-title":"The Virtual Brain Integrates Computational Modeling and Multimodal Neuroimaging.","volume":"3","author":"P Ritter","year":"2013","journal-title":"Brain Connect"},{"issue":"6139","key":"pcbi.1012683.ref091","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.1235381","article-title":"BigBrain: An Ultrahigh-Resolution 3D Human Brain Model","volume":"340","author":"K Amunts","year":"1979","journal-title":"Science"},{"key":"pcbi.1012683.ref092","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data.","volume":"189","author":"A Arnatkevi\u010di\u016bt\u0117","year":"2019","journal-title":"Neuroimage [Internet]."},{"issue":"4","key":"pcbi.1012683.ref093","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1093\/brain\/awy035","article-title":"Atlas of the normal intracranial electroencephalogram: neurophysiological awake activity in different cortical areas","volume":"141","author":"B Frauscher","year":"2018","journal-title":"Brain"},{"key":"pcbi.1012683.ref094","first-page":"309","author":"A. Scimemi","year":"2019"},{"issue":"4","key":"pcbi.1012683.ref095","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.tics.2020.01.008","article-title":"Linking Structure and Function in Macroscale Brain Networks.","volume":"24","author":"LE Su\u00e1rez","year":"2020","journal-title":"Trends Cogn Sci [Internet]."},{"issue":"2","key":"pcbi.1012683.ref096","first-page":"87","article-title":"Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat Rev Neurosci","volume":"11","author":"C Giaume","year":"2010","journal-title":"Internet]"},{"issue":"12","key":"pcbi.1012683.ref097","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1002\/hbm.24337","article-title":"The morphology of the human cerebrovascular system","volume":"39","author":"M Bernier","year":"2018","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"pcbi.1012683.ref098","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1196\/annals.1444.017","article-title":"Cerebral White Matter","volume":"1142","author":"JD Schmahmann","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"pcbi.1012683.ref099","article-title":"Virtual brain twins: from basic neuroscience to clinical use.","volume":"11","author":"HE Wang","year":"2024","journal-title":"Natl Sci Rev"},{"issue":"74","key":"pcbi.1012683.ref100","first-page":"4248","article-title":"Connectome Mapper 3: A Flexible and Open-Source Pipeline Software for Multiscale Multimodal Human Connectome Mapping. J Open Source Softw","volume":"7","author":"S Tourbier","year":"2022","journal-title":"Internet]"},{"key":"pcbi.1012683.ref101","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuroimage.2013.05.041","article-title":"The WU-Minn Human Connectome Project: An overview.","volume":"80","author":"DC Van Essen","year":"2013","journal-title":"Neuroimage [Internet]."},{"key":"pcbi.1012683.ref102","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuroimage.2013.04.127","article-title":"The minimal preprocessing pipelines for the Human Connectome Project.","volume":"80","author":"MF Glasser","year":"2013","journal-title":"Neuroimage [Internet]."},{"issue":"6","key":"pcbi.1012683.ref103","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/jmri.27188","article-title":"Mapping Structural Connectivity Using Diffusion MRI: Challenges and Opportunities","volume":"53","author":"C Yeh","year":"2021","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"(","key":"pcbi.1012683.ref104","doi-asserted-by":"crossref","first-page":"116889","DOI":"10.1016\/j.neuroimage.2020.116889","article-title":"TractoFlow: A robust, efficient and reproducible diffusion MRI pipeline leveraging Nextflow & Singularity.","volume":"218","author":"G Theaud","year":"2020","journal-title":"Neuroimage [Internet]."},{"key":"pcbi.1012683.ref105","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.neuroimage.2017.12.036","article-title":"Surface-enhanced tractography (SET).","volume":"169","author":"E St-Onge","year":"2018","journal-title":"Neuroimage [Internet]."},{"issue":"31","key":"pcbi.1012683.ref106","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba8245","article-title":"A new method for accurate in vivo mapping of human brain connections using microstructural and anatomical information","volume":"6","author":"S Schiavi","year":"2020","journal-title":"Sci Adv"},{"issue":"1","key":"pcbi.1012683.ref107","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroimage.2010.07.033","article-title":"Unbiased average age-appropriate atlases for pediatric studies.","volume":"54","author":"V Fonov","year":"2011","journal-title":"Neuroimage [Internet]."},{"issue":"2","key":"pcbi.1012683.ref108","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer.","volume":"62","author":"B. Fischl","year":"2012","journal-title":"Neuroimage [Internet]."},{"key":"pcbi.1012683.ref109","volume-title":"Version 9.12.0 (R2022a).","author":"MATLAB","year":"2022"},{"issue":"3","key":"pcbi.1012683.ref110","first-page":"245","article-title":"Averaging Correlations: Expected Values and Bias in Combined Pearson r s and Fisher\u2019s z Transformations. J Gen Psychol","volume":"125","author":"DM Corey","year":"1998","journal-title":"Internet]"},{"issue":"1","key":"pcbi.1012683.ref111","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1038\/ncomms7868","article-title":"Ranking in interconnected multilayer networks reveals versatile nodes.","volume":"6","author":"M De Domenico","year":"2015","journal-title":"Nat Commun [Internet]."},{"issue":"1","key":"pcbi.1012683.ref112","first-page":"011027","article-title":"Identifying Modular Flows on Multilayer Networks Reveals Highly Overlapping Organization in Interconnected Systems","volume":"5","author":"M De Domenico","year":"2015","journal-title":"Phys Rev X"},{"issue":"4","key":"pcbi.1012683.ref113","first-page":"041022","article-title":"Mathematical Formulation of Multilayer Networks","volume":"3","author":"M De Domenico","year":"2013","journal-title":"Phys Rev X"},{"issue":"1","key":"pcbi.1012683.ref114","first-page":"6864","article-title":"Structural reducibility of multilayer networks. Nat Commun","volume":"6","author":"M De Domenico","year":"2015","journal-title":"Internet]"},{"issue":"1","key":"pcbi.1012683.ref115","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1038\/s41467-020-19160-7","article-title":"The misuse of colour in science communication","volume":"11","author":"F Crameri","year":"2020","journal-title":"Nat Commun"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T14:04:50Z","timestamp":1736777090000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012683"}},"subtitle":[],"editor":[{"given":"Hugues","family":"Berry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":115,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1012683","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}