{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:26:25Z","timestamp":1782271585471,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012746","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000}}],"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["PHY-2229929"],"award-info":[{"award-number":["PHY-2229929"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Sensory neurons continually adapt their response characteristics according to recent stimulus history. However, it is unclear how such a reactive process can benefit the organism. Here, we test the hypothesis that adaptation actually acts proactively in the sense that it optimally adjusts sensory encoding for future stimuli. We first quantified human subjects\u2019 ability to discriminate visual orientation under different adaptation conditions. Using an information theoretic analysis, we found that adaptation leads to a reallocation of coding resources such that encoding accuracy peaks at the mean orientation of the adaptor while total coding capacity remains constant. We then asked whether this characteristic change in encoding accuracy is predicted by the temporal statistics of natural visual input. Analyzing the retinal input of freely behaving human subjects showed that the distribution of local visual orientations in the retinal input stream indeed peaks at the mean orientation of the preceding input history (i.e., the adaptor). We further tested our hypothesis by analyzing the internal sensory representations of a recurrent neural network trained to predict the next frame of natural scene videos (PredNet). Simulating our human adaptation experiment with PredNet, we found that the network exhibited the same change in encoding accuracy as observed in human subjects. Taken together, our results suggest that adaptation-induced changes in encoding accuracy prepare the visual system for future stimuli.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1012746","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T15:15:04Z","timestamp":1737126904000},"page":"e1012746","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adaptation optimizes sensory encoding for future stimuli"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-3250","authenticated-orcid":true,"given":"Jiang","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin A","family":"Rothkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-1515","authenticated-orcid":true,"given":"Alan A","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"issue":"1","key":"pcbi.1012746.ref001","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0896-6273(00)00103-3","article-title":"Adaptation-induced plasticity of orientation tuning in adult visual cortex","volume":"28","author":"V Dragoi","year":"2000","journal-title":"Neuron"},{"issue":"9","key":"pcbi.1012746.ref002","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nn900","article-title":"Dynamics of neuronal sensitivity in visual cortex and local feature discrimination","volume":"5","author":"V Dragoi","year":"2002","journal-title":"Nat Neurosci"},{"issue":"2","key":"pcbi.1012746.ref003","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1523\/JNEUROSCI.3345-12.2013","article-title":"Distinct effects of brief and prolonged adaptation on orientation tuning in primary visual cortex","volume":"33","author":"CA Patterson","year":"2013","journal-title":"J Neurosci"},{"issue":"4","key":"pcbi.1012746.ref004","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0896-6273(03)00438-0","article-title":"Neuronal adaptation to visual motion in area MT of the macaque","volume":"39","author":"A Kohn","year":"2003","journal-title":"Neuron"},{"issue":"7","key":"pcbi.1012746.ref005","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nn1267","article-title":"Adaptation changes the direction tuning of macaque MT neurons","volume":"7","author":"A Kohn","year":"2004","journal-title":"Nat Neurosci"},{"issue":"2","key":"pcbi.1012746.ref006","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1364\/JOSAA.2.000147","article-title":"Postadaptation orientation discrimination","volume":"2","author":"D Regan","year":"1985","journal-title":"J Opt Soc Am A"},{"issue":"2","key":"pcbi.1012746.ref007","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0042-6989(00)00248-0","article-title":"Orthogonal adaptation improves orientation discrimination","volume":"41","author":"CW Clifford","year":"2001","journal-title":"Vision Res"},{"issue":"6","key":"pcbi.1012746.ref008","first-page":"609","article-title":"Does the tilt after-effect occur in the oblique meridian? 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