{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:39:16Z","timestamp":1778323156840,"version":"3.51.4"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1012947","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T17:22:20Z","timestamp":1744910540000},"page":"e1012947","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Eleven quick tips to unlock the power of in vivo data science"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-0727","authenticated-orcid":true,"given":"Troy J.","family":"Kieran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taronna R.","family":"Maines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-7368","authenticated-orcid":true,"given":"Jessica A.","family":"Belser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"issue":"4","key":"pcbi.1012947.ref001","doi-asserted-by":"crossref","first-page":"FSO63","DOI":"10.4155\/fso.15.63","article-title":"Animal models are essential to biological research: issues and perspectives","volume":"1","author":"F Barr\u00e9-Sinoussi","year":"2015","journal-title":"Future Sci OA"},{"key":"pcbi.1012947.ref002","first-page":"11","article-title":"The three Rs of Russell & Burch and the testing of biological products","volume":"86","author":"M Balls","year":"1996","journal-title":"Dev Biol Stand"},{"key":"pcbi.1012947.ref003","doi-asserted-by":"crossref","DOI":"10.3897\/rio.9.e105198","article-title":"How open science can support the 3Rs and improve animal research","volume":"9","author":"M Janssens","year":"2023","journal-title":"RIO"},{"issue":"7","key":"pcbi.1012947.ref004","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"N Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"pcbi.1012947.ref005","doi-asserted-by":"crossref","first-page":"160018","DOI":"10.1038\/sdata.2016.18","article-title":"The FAIR Guiding Principles for scientific data management and stewardship","volume":"3","author":"MD Wilkinson","year":"2016","journal-title":"Sci Data"},{"issue":"4","key":"pcbi.1012947.ref006","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/ilar.43.4.202","article-title":"Practical aspects of experimental design in animal research","volume":"43","author":"PD Johnson","year":"2002","journal-title":"ILAR J"},{"issue":"1","key":"pcbi.1012947.ref007","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s42003-024-06629-0","article-title":"Machine learning approaches for influenza A virus risk assessment identifies predictive correlates using ferret model in vivo data","volume":"7","author":"TJ Kieran","year":"2024","journal-title":"Commun Biol"},{"issue":"3","key":"pcbi.1012947.ref008","doi-asserted-by":"crossref","first-page":"e58337","DOI":"10.1371\/journal.pone.0058337","article-title":"Clinical profiles associated with influenza disease in the ferret model","volume":"8","author":"GV Stark","year":"2013","journal-title":"PLoS One"},{"key":"pcbi.1012947.ref009","doi-asserted-by":"crossref","first-page":"e07969","DOI":"10.7554\/eLife.07969","article-title":"Mapping influenza transmission in the ferret model to transmission in humans","volume":"4","author":"MG Buhnerkempe","year":"2015","journal-title":"Elife"},{"issue":"6","key":"pcbi.1012947.ref010","doi-asserted-by":"crossref","first-page":"e0045922","DOI":"10.1128\/msystems.00459-22","article-title":"Predicting influenza A virus infection in the lung from hematological data with machine learning","volume":"7","author":"SS Jhutty","year":"2022","journal-title":"mSystems"},{"issue":"10","key":"pcbi.1012947.ref011","doi-asserted-by":"crossref","first-page":"e1004525","DOI":"10.1371\/journal.pcbi.1004525","article-title":"Ten simple rules for creating a good data management plan","volume":"11","author":"WK Michener","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"8","key":"pcbi.1012947.ref012","doi-asserted-by":"crossref","first-page":"e1010397","DOI":"10.1371\/journal.pcbi.1010397","article-title":"Ten simple rules for maximizing the recommendations of the NIH data management and sharing plan","volume":"18","author":"S Gonzales","year":"2022","journal-title":"PLoS Comput Biol"},{"issue":"10","key":"pcbi.1012947.ref013","doi-asserted-by":"crossref","first-page":"e1005097","DOI":"10.1371\/journal.pcbi.1005097","article-title":"Ten simple rules for digital data storage","volume":"12","author":"EM Hart","year":"2016","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"pcbi.1012947.ref014","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/00031305.2017.1375989","article-title":"Data organization in spreadsheets","volume":"72","author":"KW Broman","year":"2018","journal-title":"Am Stat"},{"issue":"4","key":"pcbi.1012947.ref015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ilar.43.4.244","article-title":"Guidelines for the design and statistical analysis of experiments using laboratory animals","volume":"43","author":"MFW Festing","year":"2002","journal-title":"ILAR J"},{"issue":"8","key":"pcbi.1012947.ref016","doi-asserted-by":"crossref","first-page":"e1012460","DOI":"10.1371\/journal.ppat.1012460","article-title":"Data alchemy, from lab to insight: transforming in vivo experiments into data science gold","volume":"20","author":"TJ Kieran","year":"2024","journal-title":"PLoS Pathog"},{"issue":"3","key":"pcbi.1012947.ref017","doi-asserted-by":"crossref","first-page":"dmm050511","DOI":"10.1242\/dmm.050511","article-title":"Key considerations to improve the normalization, interpretation and reproducibility of morbidity data in mammalian models of viral disease","volume":"17","author":"JA Belser","year":"2024","journal-title":"Dis Model Mech"},{"issue":"1","key":"pcbi.1012947.ref018","doi-asserted-by":"crossref","first-page":"e0153622","DOI":"10.1128\/jvi.01536-22","article-title":"Utility of human in vitro data in risk assessments of influenza A virus using the Ferret Model","volume":"97","author":"HM Creager","year":"2023","journal-title":"J Virol"},{"key":"pcbi.1012947.ref019","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jclinepi.2021.01.008","article-title":"Framework for the treatment and reporting of missing data in observational studies: the treatment and reporting of missing data in Observational Studies framework","volume":"134","author":"KJ Lee","year":"2021","journal-title":"J Clin Epidemiol"},{"issue":"8","key":"pcbi.1012947.ref020","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2217\/fmb.13.64","article-title":"Considerations regarding appropriate sample size for conducting ferret transmission experiments","volume":"8","author":"JA Belser","year":"2013","journal-title":"Future Microbiol"},{"issue":"1","key":"pcbi.1012947.ref021","doi-asserted-by":"crossref","first-page":"e55358","DOI":"10.1371\/journal.pone.0055358","article-title":"Sample size considerations for one-to-one animal transmission studies of the influenza A viruses","volume":"8","author":"H Nishiura","year":"2013","journal-title":"PLoS One"},{"key":"pcbi.1012947.ref022","volume-title":"Guide for the care and use of laboratory animals","author":"NRC.","year":"2011"},{"key":"pcbi.1012947.ref023","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.brainresbull.2022.11.020","article-title":"Reframing the perception of outliers and negative data in translational research","volume":"192","author":"ME Emborg","year":"2023","journal-title":"Brain Res Bull"},{"issue":"7","key":"pcbi.1012947.ref024","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41583-020-0313-3","article-title":"Reproducibility of animal research in light of biological variation","volume":"21","author":"B Voelkl","year":"2020","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"pcbi.1012947.ref025","doi-asserted-by":"crossref","first-page":"e0117422","DOI":"10.1128\/mbio.01174-22","article-title":"Robustness of the Ferret Model for influenza risk assessment studies: a cross-laboratory exercise","volume":"13","author":"JA Belser","year":"2022","journal-title":"mBio"},{"issue":"1","key":"pcbi.1012947.ref026","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s44298-024-00074-w","article-title":"Optimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets","volume":"2","author":"TJ Kieran","year":"2024","journal-title":"NPJ Viruses"},{"issue":"1","key":"pcbi.1012947.ref027","doi-asserted-by":"crossref","first-page":"e1010749","DOI":"10.1371\/journal.pcbi.1010749","article-title":"Ten simple rules for using public biological data for your research","volume":"19","author":"VH Oza","year":"2023","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"pcbi.1012947.ref028","doi-asserted-by":"crossref","first-page":"e1009768","DOI":"10.1371\/journal.pcbi.1009768","article-title":"Ten simple rules for improving research data discovery","volume":"18","author":"N Contaxis","year":"2022","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"pcbi.1012947.ref029","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/ani3010238","article-title":"Animal experiments in biomedical research: a historical perspective","volume":"3","author":"NH Franco","year":"2013","journal-title":"Animals (Basel)"},{"issue":"8","key":"pcbi.1012947.ref030","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/ph17081053","article-title":"An evaluation of sex-specific pharmacokinetics and bioavailability of Kokusaginine: an in vitro and in vivo investigation","volume":"17","author":"K Shang","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"pcbi.1012947.ref031","first-page":"57","article-title":"Comparison of rectal, microchip transponder, and infrared thermometry techniques for obtaining body temperature in the laboratory rabbit (Oryctolagus cuniculus)","volume":"45","author":"PH Chen","year":"2006","journal-title":"J Am Assoc Lab Anim Sci"},{"issue":"3","key":"pcbi.1012947.ref032","doi-asserted-by":"crossref","first-page":"e0118780","DOI":"10.1371\/journal.pone.0118780","article-title":"A novel video tracking method to evaluate the effect of influenza infection and antiviral treatment on ferret activity","volume":"10","author":"DY Oh","year":"2015","journal-title":"PLoS One"},{"issue":"1817","key":"pcbi.1012947.ref033","first-page":"20151453","article-title":"Disrupted seasonal biology impacts health, food security and ecosystems","volume":"282","author":"TJ Stevenson","year":"2015","journal-title":"Proc Biol Sci"},{"issue":"20","key":"pcbi.1012947.ref034","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1073\/pnas.1100768108","article-title":"Influenza virus aerosol exposure and analytical system for ferrets","volume":"108","author":"KM Gustin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pcbi.1012947.ref035","doi-asserted-by":"crossref","first-page":"e0166123","DOI":"10.1128\/jvi.01661-23","article-title":"Exploring associations between viral titer measurements and disease outcomes in ferrets inoculated with 125 contemporary influenza A viruses","volume":"98","author":"TJ Kieran","year":"2024","journal-title":"J Virol"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T17:22:27Z","timestamp":1744910547000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1012947"}},"subtitle":[],"editor":[{"given":"B.F. Francis","family":"Ouellette","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1012947","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}