{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:16:21Z","timestamp":1773324981649,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012951","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000}}],"reference-count":95,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1193857"],"award-info":[{"award-number":["GNT1193857"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["ARC (DP240101295)"],"award-info":[{"award-number":["ARC (DP240101295)"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Viertel\/Bellberry"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Contemporary models of perceptual awareness lack tractable neurobiological constraints. Inspired by recent cellular recordings in a mouse model of tactile threshold detection, we constructed a biophysical model of perceptual awareness that incorporated essential features of thalamocortical anatomy and cellular physiology. Our model reproduced, and mechanistically explains, the key\n                    <jats:italic>in vivo<\/jats:italic>\n                    neural and behavioural signatures of perceptual awareness in the mouse model, as well as the response to a set of causal perturbations. We generalised the same model (with identical parameters) to a more complex task \u2013 visual rivalry \u2013 and found that the same thalamic-mediated mechanism of perceptual awareness determined perceptual dominance. This led to the generation of a set of novel, and directly testable, electrophysiological predictions. Analyses of the model based on dynamical systems theory show that perceptual awareness in simulations of both threshold detection and visual rivalry arises from the emergent systems-level dynamics of thalamocortical loops.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1012951","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T17:33:16Z","timestamp":1744047196000},"page":"e1012951","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["A burst-dependent thalamocortical substrate for perceptual awareness"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-0503","authenticated-orcid":true,"given":"Christopher J.","family":"Whyte","sequence":"first","affiliation":[]},{"given":"Eli J.","family":"M\u00fcller","sequence":"additional","affiliation":[]},{"given":"Jaan","family":"Aru","sequence":"additional","affiliation":[]},{"given":"Matthew","family":"Larkum","sequence":"additional","affiliation":[]},{"given":"Yohan","family":"John","sequence":"additional","affiliation":[]},{"given":"Brandon R.","family":"Munn","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1762-5499","authenticated-orcid":true,"given":"James M.","family":"Shine","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"pcbi.1012951.ref001","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/acprof:oso\/9780199688890.001.0001","volume-title":"Behavioural Methods in Consciousness Research","author":"M Overgaard","year":"2015"},{"key":"pcbi.1012951.ref002","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2014.01078","article-title":"Isolating neural correlates of conscious perception from neural correlates of reporting one\u2019s perception","volume":"5","author":"M Pitts","year":"2014","journal-title":"Frontiers in Psychology"},{"issue":"10","key":"pcbi.1012951.ref003","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nn1549","article-title":"Timing of the brain events underlying access to consciousness during the attentional blink","volume":"8","author":"C Sergent","year":"2005","journal-title":"Nat Neurosci"},{"key":"pcbi.1012951.ref004","article-title":"The neural and computational architecture of feedback dynamics in mouse cortex during stimulus report","author":"S Ciceri","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"pcbi.1012951.ref005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41593-023-01488-0","article-title":"Backward masking in mice requires visual cortex","volume":"27","author":"S Gale","year":"2024","journal-title":"Nature Neuroscience"},{"issue":"1","key":"pcbi.1012951.ref006","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1038\/s41467-022-30600-4","article-title":"Multisensory task demands temporally extend the causal requirement for visual cortex in perception","volume":"13","author":"MN Oude Lohuis","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"pcbi.1012951.ref007","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1523\/JNEUROSCI.0997-16.2017","article-title":"Complex visual motion representation in mouse area V1","volume":"37","author":"G Palagina","year":"2017","journal-title":"Journal of Neuroscience"},{"issue":"20","key":"pcbi.1012951.ref008","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1016\/j.neuron.2023.09.042","article-title":"Next frontiers in consciousness research","volume":"111","author":"B He","year":"2023","journal-title":"Neuron"},{"issue":"43","key":"pcbi.1012951.ref009","article-title":"Coupling the state and contents of consciousness","volume":"13","author":"J Aru","year":"2019","journal-title":"Frontiers in Systems Neuroscience"},{"issue":"10","key":"pcbi.1012951.ref010","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.tics.2020.07.006","article-title":"Cellular mechanisms of conscious processing","volume":"24","author":"J Aru","year":"2020","journal-title":"Trends in Cognitive Sciences"},{"key":"pcbi.1012951.ref011","author":"T Bachmann","year":"2020"},{"issue":"10","key":"pcbi.1012951.ref012","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41593-020-0677-8","article-title":"Active dendritic currents gate descending cortical outputs in perception","volume":"23","author":"N Takahashi","year":"2020","journal-title":"Nat Neurosci"},{"issue":"6319","key":"pcbi.1012951.ref013","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.aah6066","article-title":"Active cortical dendrites modulate perception","volume":"354","author":"N Takahashi","year":"2016","journal-title":"Science"},{"key":"pcbi.1012951.ref014","article-title":"The thalamus integrates the macrosystems of the brain to facilitateShine JM. 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