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The tuning stability of individual cells varies over the population, and it remains unclear what drives this heterogeneity. We investigate how a neuron\u2019s tuning stability relates to its shared variability with other neurons in the population using two published datasets from posterior parietal cortex and visual cortex. We quantified the contribution of pairwise interactions to behaviour or stimulus encoding by partial information decomposition, which breaks down the mutual information between the pairwise neural activity and the external variable into components uniquely provided by each neuron and by their interactions. Information shared by the two neurons is termed \u2018redundant\u2019, and information requiring knowledge of the state of both neurons is termed \u2018synergistic\u2019. We found that a neuron\u2019s tuning stability is positively correlated with the strength of its average pairwise redundancy with the population. We hypothesize that subpopulations of neurons show greater stability because they are tuned to salient features common across multiple tasks. Regardless of the mechanistic implications of our work, the stability\u2013redundancy relationship may support improved longitudinal neural decoding in technology that has to track population dynamics over time, such as brain\u2013machine interfaces.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1013130","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:40:28Z","timestamp":1771353628000},"page":"e1013130","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Information theoretic measures of neural and behavioural coupling predict representational drift"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-4493","authenticated-orcid":true,"given":"Kristine","family":"Heiney","sequence":"first","affiliation":[]},{"given":"M\u00f3nika","family":"J\u00f3zsa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-774X","authenticated-orcid":true,"given":"Michael E.","family":"Rule","sequence":"additional","affiliation":[]},{"given":"Henning","family":"Sprekeler","sequence":"additional","affiliation":[]},{"given":"Stefano","family":"Nichele","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-0158","authenticated-orcid":true,"given":"Timothy","family":"O\u2019Leary","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"issue":"5","key":"pcbi.1013130.ref001","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.07.021","article-title":"Dynamic reorganization of neuronal activity patterns in parietal cortex","volume":"170","author":"LN Driscoll","year":"2017","journal-title":"Cell."},{"issue":"7864","key":"pcbi.1013130.ref002","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41586-021-03628-7","article-title":"Representational drift in primary olfactory cortex","volume":"594","author":"CE Schoonover","year":"2021","journal-title":"Nature."},{"issue":"19","key":"pcbi.1013130.ref003","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2021.07.062","article-title":"Representational drift in the mouse visual cortex","volume":"31","author":"D Deitch","year":"2021","journal-title":"Curr Biol."},{"issue":"1","key":"pcbi.1013130.ref004","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1038\/s41467-021-25436-3","article-title":"Stimulus-dependent representational drift in primary visual cortex","volume":"12","author":"TD Marks","year":"2021","journal-title":"Nat Commun."},{"issue":"3","key":"pcbi.1013130.ref005","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nn.3329","article-title":"Long-term dynamics of CA1 hippocampal place codes","volume":"16","author":"Y Ziv","year":"2013","journal-title":"Nat Neurosci."},{"issue":"4","key":"pcbi.1013130.ref006","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.celrep.2016.12.080","article-title":"Stability and plasticity of contextual modulation in the mouse visual cortex","volume":"18","author":"A Ranson","year":"2017","journal-title":"Cell Rep."},{"issue":"7","key":"pcbi.1013130.ref007","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tins.2013.03.008","article-title":"Steady or changing? 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