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However, evidence for prediction in sensory cortex largely comes from artificial experiments using simple, highly predictable stimuli, that arguably encourage prediction. Here, we test for sensory prediction during natural scene perception. Specifically, we use deep generative modelling to quantify the spatial predictability of receptive field (RF) patches in natural images, and compared those predictability estimates to brain responses in the mouse visual cortex\u2014while rigorously accounting for established tuning to a rich set of low-level image features and their local statistical context\u2014in a large scale survey of high-density recordings from the Allen Institute Brain Observatory. This revealed four insights. First, cortical responses across the mouse visual system are shaped by sensory predictability, with more predictable image patches evoking weaker responses. Secondly, visual cortical neurons are primarily sensitive to the predictability of higher-level image features, even in neurons in the primary visual areas that are preferentially tuned to low-level visual features. Third, unpredictability sensitivity is stronger in the superficial layers of primary visual cortex, in line with predictive coding models. Finally, these spatial prediction effects are independent of recent experience, suggesting that they rely on long-term priors about the structure of the visual world. Together, these results suggest visual cortex might predominantly predict sensory information at higher levels of abstraction\u2014a pattern bearing striking similarities to recent, successful techniques from artificial intelligence for predictive self-supervised learning.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1013136","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:56:01Z","timestamp":1768935361000},"page":"e1013136","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Higher-level spatial prediction in natural vision across mouse visual cortex"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-4007","authenticated-orcid":true,"given":"Micha","family":"Heilbron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floris P.","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"issue":"7852","key":"pcbi.1013136.ref001","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41586-020-03171-x","article-title":"Survey of spiking in the mouse visual system reveals functional hierarchy","volume":"592","author":"JH Siegle","year":"2021","journal-title":"Nature."},{"key":"pcbi.1013136.ref002","doi-asserted-by":"crossref","unstructured":"Liu G, Reda FA, Shih KJ, Wang TC, Tao A, Catanzaro B. 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