{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:53:31Z","timestamp":1767178411635,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1013178","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000}}],"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01MH130238, R01AI174932 and R01AI179417"],"award-info":[{"award-number":["R01MH130238, R01AI174932 and R01AI179417"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HIV hotspots, regions with higher prevalence than surrounding areas, are observed across Africa, yet their formation and persistence mechanisms remain poorly understood. We hypothesized that random fluctuations during the early stages of the HIV epidemic (1978\u20131982), amplified by positive feedback between HIV incidence and prevalence, play a critical role in hotspot formation and persistence. To explore this, we applied a network-based HIV transmission model, focusing on randomness in the spatial structure of the epidemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We adapted a previously validated agent-based network HIV transmission model, EMOD-HIV, to simulate HIV spread in western Kenya communities. The model includes demographics, age-structured social networks, and HIV transmission, prevention, and treatment. We simulated 250 identical communities, introducing stochastic fluctuations in network structure and case importation. Outliers were defined as communities with prevalence\u2009&gt;\u20091.5x the median, and persistence as meeting these criteria for &gt;70% of 1980\u20132050. We systematically varied community size (1,000\u201310,000), importation timing (1978\u20131982), and importation patterns (spread over 1, 3, or 5 years), and calculated the proportion of outliers and persistent outliers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HIV prevalence outliers were more common in smaller communities: in 1990, 25.3% (uncertainty interval: 22.3%\u201328.2%) of 1,000-person communities vs. 9.1% (uncertainty interval: 6.9%\u201311.4%) of 10,000-person communities. By 2050, 21.6% of 1,000-person communities were persistent outliers, compared to none in larger communities. Autocorrelation of HIV prevalence was high (Pearson\u2019s correlation coefficient 0.801 [95% CI: 0.796\u20130.806] for 1,000-person communities), reflecting feedback that amplified early fluctuations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early random fluctuations contribute to the emergence and persistence of prevalence outliers, especially in smaller communities. Recognizing the role of randomness in prevalence outlier formation in these settings is crucial for refining HIV control strategies, as traditional methods may overlook these areas. Adaptive surveillance systems can enhance detection and intervention efforts for HIV and future pandemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pcbi.1013178","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T13:39:21Z","timestamp":1750081161000},"page":"e1013178","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncovering the impact of randomness in HIV hotspot formation: A mathematical modeling study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3131-2368","authenticated-orcid":true,"given":"Nao","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel T.","family":"Citron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel M.","family":"Mwalili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan K.","family":"Gathungu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego F.","family":"Cuadros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-7093","authenticated-orcid":true,"given":"Anna","family":"Bershteyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"issue":"1","key":"pcbi.1013178.ref001","first-page":"32","article-title":"Understanding culture and HIV\/AIDS in sub-Saharan Africa","volume":"10","author":"S Sovran","year":"2013","journal-title":"SAHARA J"},{"key":"pcbi.1013178.ref002","doi-asserted-by":"crossref","DOI":"10.1016\/j.amepre.2021.05.029","article-title":"HIV 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