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Several control architectures have been proposed for simulating locomotor tasks, based on fully feedback, reflex-based, controllers, or on feedforward architectures mimicking the Central Pattern Generators. Hybrid architectures integrating both feedback and feedforward components represent a viable alternative to fully feedback or feedforward controllers. Current literature on controller-based simulations almost exclusively presents task-specific controllers that do not generalize across different tasks. The task-specificity of current controllers limits the generalizability of the neurophysiological principles behind such controllers. Here we propose a hybrid controller for predictive simulations of cycling where the feedforward component is based on a well-known theoretical model, the Unit Burst Generation model, and the feedback component includes a limited set of reflex pathways, expected to be active during steady cycling. We show that this controller can simulate physiological stationary cycling patterns at different desired speeds and seat heights. We also show that the controller can generalize to walking behaviors by just adding an additional control component for accounting balance needs. The controller here proposed, although simple in design, represent an instance of physiologically inspired generalizable controller for cyclical lower limb tasks.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1013494","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:02:15Z","timestamp":1757707335000},"page":"e1013494","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["A physiologically inspired hybrid CPG\/Reflex controller for cycling simulations that generalizes to walking"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2289-9331","authenticated-orcid":true,"given":"Giacomo","family":"Severini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"issue":"1946","key":"pcbi.1013494.ref001","first-page":"20202432","article-title":"Perspective on musculoskeletal modelling and predictive simulations of human movement to assess the neuromechanics of gait","volume":"288","author":"F De Groote","year":"2021","journal-title":"Proc Biol Sci"},{"issue":"5","key":"pcbi.1013494.ref002","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1123\/jab.2023-0015","article-title":"Modeling human suboptimal control: a review","volume":"39","author":"A Bersani","year":"2023","journal-title":"J Appl Biomech"},{"issue":"10","key":"pcbi.1013494.ref003","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1007\/s10439-016-1591-9","article-title":"Evaluation of direct collocation optimal control problem formulations for solving the muscle redundancy problem","volume":"44","author":"F De Groote","year":"2016","journal-title":"Ann Biomed Eng"},{"issue":"16","key":"pcbi.1013494.ref004","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1113\/JP270228","article-title":"A neural circuitry that emphasizes spinal feedback generates diverse behaviours of human locomotion","volume":"593","author":"S Song","year":"2015","journal-title":"J Physiol"},{"issue":"2","key":"pcbi.1013494.ref005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00204049","article-title":"A model of the neuro-musculo-skeletal system for human locomotion. 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