{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:53:31Z","timestamp":1767178411140,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1013531","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000}}],"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MRC\/DFID Research Leader Fellowship","award":["MR\/S005293\/1"],"award-info":[{"award-number":["MR\/S005293\/1"]}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-039626"],"award-info":[{"award-number":["INV-039626"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-039626"],"award-info":[{"award-number":["INV-039626"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214320"],"award-info":[{"award-number":["214320"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["208812\/Z\/17\/Z"],"award-info":[{"award-number":["208812\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Global research unit","award":["16\/136\/46"],"award-info":[{"award-number":["16\/136\/46"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Measles outbreaks continue to cause a large burden of disease in Africa including Kenya. We used information from regular serological surveys in Kilifi Health and Demographic Surveillance System (KHDSS) in combination with mathematical modelling to estimate the relative contribution of the vaccination programme to current measles immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed a static birth cohort model to track the proportion of children who are either measles na\u00efve or seroconverted due to natural infection or vaccination through first dose of measles-containing vaccine (MCV1), the second dose (MCV2), or supplementary immunisation activities (SIAs). We fitted the model to biennial paediatric serological survey and case notification data and used vaccination coverage estimates from the KHDSS to estimate the relative contributions of vaccination and infection to measles immunity in Kilifi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We estimated that between 2009 and 2021, 60% (95%CI 55\u201364%) of measles seroconversion in Kilifi was attributable to MCV1, with MCV2 contributing 1.0% (95%CI 0.9-1.1%) since its introduction. Natural infection and SIAs accounted for 24% (95%CI 17\u201331%) and 16% (95%CI 14\u201319%), respectively. A hypothetical 10% increase in MCV1 coverage increased the seroconversion attributed to MCV1 to 67% (95%CI 63\u201371%), with concurrent reductions in seroconversion from natural infection and SIAs to 13% (95%CI 9\u201318%) and 10% (95%CI 9\u201312%), respectively. Importantly, this same 10% increase in MCV1, if administered promptly at 9 months, could potentially reduce seroconversion from natural infection further from 24% to 11% (95%CI 07\u201315%) and reliance on SIAs from 16% to 8% (95% CI 7\u201310%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Optimizing routine coverage timing and uptake is crucial for reducing SIAs dependence and measles susceptibility. A 10% MCV1 coverage increase could have halved susceptibility and lessened SIA demand, highlighting the potential of minor improvements in coverage to alleviate measles and reduce costly SIAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pcbi.1013531","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T17:40:46Z","timestamp":1758562846000},"page":"e1013531","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-3537","authenticated-orcid":true,"given":"Caroline","family":"Mburu","sequence":"first","affiliation":[]},{"given":"John","family":"Ojal","sequence":"additional","affiliation":[]},{"given":"Rose","family":"Selim","sequence":"additional","affiliation":[]},{"given":"Rose","family":"Ombati","sequence":"additional","affiliation":[]},{"given":"Donald","family":"Akech","sequence":"additional","affiliation":[]},{"given":"Boniface","family":"Karia","sequence":"additional","affiliation":[]},{"given":"James","family":"Tuju","sequence":"additional","affiliation":[]},{"given":"Antipa","family":"Sigilai","sequence":"additional","affiliation":[]},{"given":"Gaby","family":"Smits","sequence":"additional","affiliation":[]},{"given":"Pieter van","family":"Gageldonk","sequence":"additional","affiliation":[]},{"given":"Fiona van der","family":"Klis","sequence":"additional","affiliation":[]},{"given":"Eunice","family":"Kagucia","sequence":"additional","affiliation":[]},{"given":"Anthony","family":"Scott","sequence":"additional","affiliation":[]},{"given":"Ifedayo","family":"Adetifa","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Flasche","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"issue":"17","key":"pcbi.1013531.ref001","doi-asserted-by":"crossref","first-page":"436","DOI":"10.15585\/mmwr.mm6617a2","article-title":"Progress toward measles elimination\u2014African Region, 2013\u20132016","volume":"66","author":"BG Masresha","year":"2017","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"pcbi.1013531.ref002","unstructured":"Organization WHO. 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