{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:39:16Z","timestamp":1776735556863,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1013899","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM133780"],"award-info":[{"award-number":["R35GM133780"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017023","name":"Paul G. Allen Frontiers Group","doi-asserted-by":"publisher","award":["Allen Distinguished Investigator Award"],"award-info":[{"award-number":["Allen Distinguished Investigator Award"]}],"id":[{"id":"10.13039\/100017023","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Shapiro-Silverberg Fund for the Advancement of Translational Research"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Proteins function through dynamic interactions with other proteins in cells, forming complex networks fundamental to cellular processes. While high-resolution and high-throughput methods have significantly advanced our understanding of how proteins interact with each other, the molecular details of many important protein-protein interactions are still poorly characterized, especially in non-mammalian species, including\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . Recent advancements in deep learning techniques have enabled the prediction of molecular details in various cellular pathways at the network level. In this study, we used AlphaFold2 Multimer to examine and predict protein-protein interactions from both physical and functional datasets in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . We found that functional associations contribute significantly to high-confidence predictions. Through detailed structural analysis, we also found the importance of intrinsically disordered regions in the predicted high-confidence interactions. Our study highlights the importance of disordered regions in protein-protein interactions and demonstrates the importance of incorporating functional interactions in predicting physical interactions between proteins. We further compiled an interactive web interface to present these predictions, facilitating functional exploration, comparative analysis, and the generation of mechanistic hypotheses for future studies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1013899","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:37:10Z","timestamp":1769107030000},"page":"e1013899","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["A predicted structural interactome reveals binding interference from intrinsically disordered 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