{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:46:43Z","timestamp":1783025203512,"version":"3.54.6"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1013934","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000}}],"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000961","name":"Weizmann Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000961","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGP0032\/2022"],"award-info":[{"award-number":["RGP0032\/2022"]}],"id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","award":["RPG-2021-226"],"award-info":[{"award-number":["RPG-2021-226"]}],"id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Research Council","award":["EP\/Y02799X\/1"],"award-info":[{"award-number":["EP\/Y02799X\/1"]}]},{"name":"European Research Council","award":["ERC-SyG 101071793"],"award-info":[{"award-number":["ERC-SyG 101071793"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Cell migration\n                    <jats:italic>in vivo<\/jats:italic>\n                    is often guided by chemical signaling, i.e., chemotaxis. For immune cells performing chemotaxis in the organism, this process is influenced by the complex geometry of the tissue environment. In this study, we use a theoretical model of branched cell migration on a network to explore the cellular response to chemical gradients. The model predicts the response of a branched cell to a chemical gradient: how the cell reorients its internal polarity and how it navigates through a complex environment up a chemical gradient. We then compare the model\u2019s predictions with experimental observations of neutrophils migrating to the site of a laser-inflicted wound in a zebrafish larva fin, and neutrophils migrating\n                    <jats:italic>in vitro<\/jats:italic>\n                    inside a regular lattice of pillars. We find that the model captures the details of the subcellular response to the chemokine gradient, as well as qualitative characteristics of the large-scale migration, suggesting that the neutrophils behave as fast cells, which explains the functionality of these immune cells.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1013934","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:47:04Z","timestamp":1770144424000},"page":"e1013934","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-376X","authenticated-orcid":true,"given":"Jiayi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Ron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-557X","authenticated-orcid":true,"given":"Ivanna","family":"Williantarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-8749","authenticated-orcid":true,"given":"Antonios","family":"Georgantzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid de","family":"Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sixt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milka","family":"Sarris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-1139","authenticated-orcid":true,"given":"Nir S.","family":"Gov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"issue":"5","key":"pcbi.1013934.ref001","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.devcel.2020.02.013","article-title":"Of cell shapes and motion: the physical basis of animal cell migration","volume":"52","author":"DL Bodor","year":"2020","journal-title":"Dev Cell."},{"issue":"6519","key":"pcbi.1013934.ref002","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.aaz4741","article-title":"Tissue topography steers migrating Drosophila border cells","volume":"370","author":"W Dai","year":"2020","journal-title":"Science."},{"key":"pcbi.1013934.ref003","doi-asserted-by":"crossref","unstructured":"S\u00e1ez PJ, Barbier L, Attia R, Thiam HR, Piel M, Vargas P. 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