{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:40:38Z","timestamp":1771875638777,"version":"3.50.1"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["875052"],"award-info":[{"award-number":["875052"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research Agency","doi-asserted-by":"crossref","award":["P2-0209"],"award-info":[{"award-number":["P2-0209"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Coordinating a large-scale digital health project requires a unique mix of scientific leadership, administrative skill, and human sensitivity. Drawing from our experience leading CAPABLE, a European Horizon 2020 project aimed at improving the quality of life of cancer patients through AI and telemedicine, we present ten practical rules for navigating the complex landscape of multi-partner biomedical research. These rules address challenges such as building balanced consortia, managing timelines and regulatory requirements, ensuring cultural alignment, and promoting long-term impact through dissemination and exploitation. The paper specifically addresses international research projects at the intersection of healthcare and IT and their peculiar challenges, typically connected to the interplay of different actors such as academics, healthcare personnel, and industry partners located in different countries, each from diverse backgrounds and different working practices. Our goal is to provide researchers and project coordinators with concrete guidance to increase the likelihood of success in future large digital health initiatives.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1013957","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:26:52Z","timestamp":1771871212000},"page":"e1013957","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ten simple rules for coordinating a large digital health project: Perspectives from EU and implications for global contexts"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-9825","authenticated-orcid":true,"given":"Lucia","family":"Sacchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bla\u017e","family":"Zupan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-2561","authenticated-orcid":true,"given":"Silvana","family":"Quaglini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"1","key":"pcbi.1013957.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12992-017-0319-4","article-title":"Good collaborative practice: reforming capacity building governance of international health research partnerships","volume":"14","author":"CL Ward","year":"2018","journal-title":"Global Health"},{"issue":"1","key":"pcbi.1013957.ref002","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40504-020-00109-z","article-title":"Governance of research consortia: challenges of implementing Responsible Research and Innovation within Europe","volume":"16","author":"M Morrison","year":"2020","journal-title":"Life Sci Soc Policy"},{"key":"pcbi.1013957.ref003","volume-title":"Global strategy on digital health 2020\u20132025","author":"World Health Organization","year":"2021"},{"issue":"1","key":"pcbi.1013957.ref004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.hitech.2013.12.004","article-title":"Managing large-scale IS\/IT projects in the public sector: problems and causes leading to poor performance","volume":"25","author":"P Patanakul","year":"2014","journal-title":"J High Technol Manag Res"},{"issue":"5","key":"pcbi.1013957.ref005","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ijproman.2015.02.001","article-title":"Managing collaborative research projects: a synthesis of project management literature and directives for future research","volume":"33","author":"vom Brocke J","year":"2015","journal-title":"Int J Project Manag"},{"key":"pcbi.1013957.ref006","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijmedinf.2017.02.010","article-title":"Assessment of a personalized and distributed patient guidance system","volume":"101","author":"M Peleg","year":"2017","journal-title":"Int J Med Inform"},{"key":"pcbi.1013957.ref007","doi-asserted-by":"crossref","DOI":"10.2196\/49252","article-title":"An eHealth App (CAPABLE) providing symptom monitoring, well-being interventions, and educational material for patients with melanoma treated with immune checkpoint inhibitors: protocol for an exploratory intervention trial","volume":"12","author":"I Fraterman","year":"2023","journal-title":"JMIR Res Protoc"},{"issue":"5","key":"pcbi.1013957.ref008","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/jamia\/ocx159","article-title":"A dashboard-based system for supporting diabetes care","volume":"25","author":"A Dagliati","year":"2018","journal-title":"J Am Med Inform Assoc"},{"key":"pcbi.1013957.ref009","unstructured":"European Commission D-G for R and I. Funding and tenders portal \u2013 survey report. 2022."},{"key":"pcbi.1013957.ref010","unstructured":"APRE. Horizon Europe implementation guide; 2023. Available from: https:\/\/apre.it\/wp-content\/uploads\/2023\/06\/horizon-europe-implementation-KI0323236ENN.pdfAPRE"},{"key":"pcbi.1013957.ref011","unstructured":"Horizon Results Booster [cited 14 Nov 2025]. Available from: https:\/\/www.horizonresultsbooster.eu\/"},{"key":"pcbi.1013957.ref012","unstructured":"Dumitriu A. Capable project residency [cited 2025 Nov 14]. Available from: https:\/\/annadumitriu.co.uk\/portfolio\/capable-project-residency"},{"issue":"2","key":"pcbi.1013957.ref013","first-page":"4","article-title":"A recipe for successful collaboration: shared creative work experiences (SCrWE) among co-researchers | Ein Rezept f\u00fcr erfolgreiche Zusammenarbeit: shared creative work experiences (SCrWE) in Forschungsteams","volume":"25","author":"CD Howell","year":"2024","journal-title":"Forum Qualitative Sozialforschung"},{"key":"pcbi.1013957.ref014","unstructured":"Carruthers R. 34 virtual team building activities for remote employees. Together Platform; 2021. Available from: https:\/\/www.togetherplatform.com\/blog\/10-virtual-team-building-activities-for-your-remote-employees"},{"key":"pcbi.1013957.ref015","unstructured":"Virtual team building [cited 2025 Dec 7]. Available from: https:\/\/www.virtualteambuilding.eu\/"},{"key":"pcbi.1013957.ref016","unstructured":"CS_AIW (Cancer Survivorship \u2013 AI for wellbeing) cluster of projects [cited 14 Nov 2025]. Available from: https:\/\/www.cs-aiw.eu\/"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1013957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:26:55Z","timestamp":1771871215000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1013957"}},"subtitle":[],"editor":[{"given":"Scott","family":"Markel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1013957","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}