{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:44:23Z","timestamp":1775303063781,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T00:00:00Z","timestamp":1138924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.0020013","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T22:14:40Z","timestamp":1138659280000},"page":"e13","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":114,"title":["Complex Genetic Interactions in a Quantitative Trait Locus"],"prefix":"10.1371","volume":"2","author":[{"given":"Himanshu","family":"Sinha","sequence":"first","affiliation":[]},{"given":"Bradly P","family":"Nicholson","sequence":"additional","affiliation":[]},{"given":"Lars M","family":"Steinmetz","sequence":"additional","affiliation":[]},{"given":"John H","family":"McCusker","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2006,2,3]]},"reference":[{"key":"pgen-0020013-b001","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/416326a","article-title":"Dissecting the architecture of a quantitative trait locus in yeast.","volume":"416","year":"2002","journal-title":"Nature"},{"key":"pgen-0020013-b002","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature03480","article-title":"Epistasis and balanced polymorphism influencing complex trait variation.","volume":"435","year":"2005","journal-title":"Nature"},{"key":"pgen-0020013-b003","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrg1407","article-title":"Epistasis: Too often neglected in complex trait studies?","volume":"5","year":"2004","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrg700","article-title":"Understanding quantitative genetic variation.","volume":"3","year":"2002","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b005","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1126\/science.1076641","article-title":"Finding genes that underlie complex traits.","volume":"298","year":"2002","journal-title":"Science"},{"key":"pgen-0020013-b006","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.genet.35.102401.090633","article-title":"The genetic architecture of quantitative traits.","volume":"35","year":"2001","journal-title":"Ann Rev Genet"},{"key":"pgen-0020013-b007","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/35076585","article-title":"Finding the molecular basis of quantitative traits: Successes and pitfalls.","volume":"2","year":"2001","journal-title":"Nat Rev Genet"},{"issue":"(Suppl)","key":"pgen-0020013-b008","first-page":"228","article-title":"Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease.","volume":"33","year":"2003","journal-title":"Nat Genet"},{"key":"pgen-0020013-b009","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrg703","article-title":"Mapping and analysis of quantitative trait loci in experimental populations.","volume":"3","year":"2002","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrg996","article-title":"Studying complex biological systems using multifactorial perturbation.","volume":"4","year":"2003","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b011","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrg1155","article-title":"Mathematical multi-locus approaches to localizing complex human trait genes.","volume":"4","year":"2003","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b012","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pbi.2004.01.011","article-title":"Genomics tools for QTL analysis and gene discovery.","volume":"7","year":"2004","journal-title":"Curr Opin Plant Biol"},{"key":"pgen-0020013-b013","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nrg1293","article-title":"Maximizing the potential of functional genomics.","volume":"5","year":"2004","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b014","unstructured":"BalakrishnanRChristieKRCostanzoMCDolinskiKDwightSS 2005 Saccharomyces Genome Database Available at: http:\/\/www.yeastgenome.org. Accessed 31 August 2005."},{"key":"pgen-0020013-b015","first-page":"D364","article-title":"CYGD: The Comprehensive Yeast Genome Database.","volume":"33","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pgen-0020013-b016","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1083\/jcb.139.7.1761","article-title":"The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole.","volume":"139","year":"1997","journal-title":"J Cell Biol"},{"key":"pgen-0020013-b017","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1091\/mbc.8.7.1361","article-title":"The yeast actin-related protein Arp2p is required for the internalization step of endocytosis.","volume":"8","year":"1997","journal-title":"Mol Biol Cell"},{"key":"pgen-0020013-b018","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1128\/MCB.17.8.4294","article-title":"EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae.","volume":"17","year":"1997","journal-title":"Mol Cell Biol"},{"key":"pgen-0020013-b019","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1091317","article-title":"Global mapping of the yeast genetic interaction network.","volume":"303","year":"2004","journal-title":"Science"},{"key":"pgen-0020013-b020","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1128\/MCB.24.9.3670-3681.2004","article-title":"Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex.","volume":"24","year":"2004","journal-title":"Mol Cell Biol"},{"key":"pgen-0020013-b021","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.127.2.373","article-title":"Endocytosis is required for the growth of vacuolar H+-ATPase-defective yeast: Identification of six new END genes.","volume":"127","year":"1994","journal-title":"J Cell Biol"},{"key":"pgen-0020013-b022","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1091\/mbc.5.9.1023","article-title":"The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.","volume":"5","year":"1994","journal-title":"Mol Biol Cell"},{"key":"pgen-0020013-b023","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome.","volume":"437","year":"2005","journal-title":"Nature"},{"key":"pgen-0020013-b024","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrg1125","article-title":"The power of the 3\u2032 UTR: Translational control and development.","volume":"4","year":"2003","journal-title":"Nat Rev Genet"},{"key":"pgen-0020013-b025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.cellbio.14.1.399","article-title":"Control of translation initiation in animals.","volume":"14","year":"1998","journal-title":"Annu Rev Cell Dev Biol"},{"key":"pgen-0020013-b026","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/BC20040066","article-title":"RNA localization in yeast: Moving towards a mechanism.","volume":"97","year":"2005","journal-title":"Biol Cell"},{"key":"pgen-0020013-b027","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1073\/pnas.84.3.779","article-title":"Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.","volume":"84","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pgen-0020013-b028","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1128\/JB.169.11.4941-4945.1987","article-title":"MKT1, a nonessential Saccharomyces cerevisiae gene with a temperature-dependent effect on replication of M2 double-stranded RNA.","volume":"169","year":"1987","journal-title":"J Bacteriol"},{"key":"pgen-0020013-b029","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/ng1674","article-title":"Quantitative trait loci mapped to single-nucleotide resolution in yeast.","volume":"37","year":"2005","journal-title":"Nat Genet"},{"key":"pgen-0020013-b030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00125817-200203000-00002","article-title":"A comprehensive review of genetic association studies.","volume":"4","year":"2002","journal-title":"Genet Med"},{"key":"pgen-0020013-b031","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/genetics\/136.4.1261","article-title":"Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.","volume":"136","year":"1994","journal-title":"Genetics"},{"key":"pgen-0020013-b032","unstructured":"RoseMDWinstonFHieterP 1990 Methods in yeast genetics: A laboratory course manual Cold Spring Harbor (New York) Cold Spring Harbor Laboratory 198 p."},{"key":"pgen-0020013-b033","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/genetics\/93.1.51","article-title":"Selection of lys2 mutants of the yeast Saccharomyces cerevisiae by the utilization of \u03b1-aminoadipate.","volume":"93","year":"1979","journal-title":"Genetics"},{"key":"pgen-0020013-b034","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/yea.320101310","article-title":"New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae.","volume":"10","year":"1994","journal-title":"Yeast"},{"key":"pgen-0020013-b035","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/(SICI)1097-0061(199910)15:14<1541::AID-YEA476>3.0.CO;2-K","article-title":"Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae.","volume":"15","year":"1999","journal-title":"Yeast"},{"key":"pgen-0020013-b036","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/AEM.61.2.630-638.1995","article-title":"Factors which affect the frequency of sporulation and tetrad formation in Saccharomyces cerevisiae baker's yeasts.","volume":"61","year":"1995","journal-title":"Appl Environ Microbiol"},{"key":"pgen-0020013-b037","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/yea.320110408","article-title":"Studies on the transformation of intact yeast cells by the LiAc\/SS-DNA\/PEG procedure.","volume":"11","year":"1995","journal-title":"Yeast"},{"key":"pgen-0020013-b038","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/(SICI)1097-0061(19960630)12:8<773::AID-YEA972>3.0.CO;2-L","article-title":"Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast.","volume":"12","year":"1996","journal-title":"Yeast"},{"key":"pgen-0020013-b039","unstructured":"AusubelFMBrentRKingstonREMooreDDSeidmanJG 2004 Current protocols in molecular biology Hoboken (New Jersey) John Wiley & Sons"},{"key":"pgen-0020013-b040","unstructured":"SokalRRRohlfFJ 2000 Biometry: The principles and practice of statistics in biological research New York W. H. Freeman and Company 887 p."},{"key":"pgen-0020013-b041","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0076-6879(91)94022-5","article-title":"Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast.","volume":"194","year":"1991","journal-title":"Methods Enzymol"},{"key":"pgen-0020013-b042","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","article-title":"A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.","volume":"122","year":"1989","journal-title":"Genetics"},{"key":"pgen-0020013-b043","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-1119(87)90131-4","article-title":"A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.","volume":"57","year":"1987","journal-title":"Gene"},{"key":"pgen-0020013-b044","unstructured":"SambrookJRussellDW 2001 Molecular cloning: A laboratory manual. Volume 1 Cold Spring Harbor (New York) Cold Spring Harbor Laboratory Press 680 p."},{"key":"pgen-0020013-b045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/yea.1057","article-title":"Positive and negative selection LYS5MX gene replacement cassettes for use in Saccharomyces cerevisiae.","volume":"21","year":"2004","journal-title":"Yeast"},{"key":"pgen-0020013-b046","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/j.1460-2075.1990.tb08116.x","article-title":"Expression in yeast of the T-urf13 protein from Texas male-sterile maize mitochondria confers sensitivity to methomyl and to Texas-cytoplasm-specific fungal toxins.","volume":"9","year":"1990","journal-title":"EMBO J"},{"key":"pgen-0020013-b047","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2144\/01312st01","article-title":"Vector for pop-in\/pop-out gene replacement in Pichia pastoris.","volume":"31","year":"2001","journal-title":"Biotechniques"},{"key":"pgen-0020013-b048","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/90837","article-title":"In vivo site-directed mutagenesis using oligonucleotides.","volume":"19","year":"2001","journal-title":"Nat Biotechnol"},{"key":"pgen-0020013-b049","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/(SICI)1097-0061(199904)15:6<507::AID-YEA369>3.0.CO;2-P","article-title":"Heterologous URA3MX cassettes for gene replacement in Saccharomyces cerevisiae.","volume":"15","year":"1999","journal-title":"Yeast"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.0020013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T09:48:28Z","timestamp":1627033708000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.0020013"}},"subtitle":[],"editor":[{"given":"James","family":"Haber","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2006,2,3]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.0020013","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,3]]}}}